| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 116,102 | 1,104,813 | +988,711 | 0.00 | 0.01 | +0.01 | buy |
| Assenagon Asset Management S.A. | 492,780 | 1,326,774 | +833,994 | 0.01 | 0.03 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 1,275,274 | 2,090,663 | +815,389 | 0.60 | 1.03 | +0.43 | buy |
| Vestal Point Capital, LP | 1,150,000 | 1,765,000 | +615,000 | 0.76 | 1.37 | +0.61 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 313,753 | +313,753 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,794,272 | 3,989,533 | +195,261 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 69,874 | 255,002 | +185,128 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 154,858 | +154,858 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 12,549 | 145,206 | +132,657 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 35,406 | 158,616 | +123,210 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 107,788 | +107,788 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 96,800 | +96,800 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 118,104 | 207,926 | +89,822 | 0.03 | 0.06 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 476,000 | 564,000 | +88,000 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 122,820 | 199,023 | +76,203 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 75,928 | +75,928 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 33,559 | 106,072 | +72,513 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 124,204 | 193,360 | +69,156 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 155,599 | 219,948 | +64,349 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 25,000 | 72,787 | +47,787 | 0.10 | 0.25 | +0.15 | buy |
| Engineers Gate Manager LP | 18,941 | 56,318 | +37,377 | 0.00 | 0.01 | +0.01 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 36,359 | +36,359 | 0.00 | 0.20 | +0.20 | buy |
| HRT FINANCIAL LP | 32,758 | 68,461 | +35,703 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 21,355 | 56,377 | +35,022 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,035 | 56,274 | +34,239 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 33,821 | +33,821 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 32,757 | +32,757 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 28,312 | 57,448 | +29,136 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 6,445 | 28,761 | +22,316 | 0.00 | 0.01 | +0.01 | buy |
| DLD Asset Management, LP | 0 | 20,000 | +20,000 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 31,147 | 51,016 | +19,869 | 0.00 | 0.00 | +0.00 | buy |
| PharVision Advisers, LLC | 0 | 17,790 | +17,790 | 0.00 | 0.17 | +0.17 | buy |
| Campbell & CO Investment Adviser LLC | 14,985 | 32,493 | +17,508 | 0.01 | 0.04 | +0.03 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,145 | +16,145 | 0.00 | 0.04 | +0.04 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14,300 | 30,432 | +16,132 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 15,308 | +15,308 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 428,857 | 443,525 | +14,668 | 0.00 | 0.00 | +0.00 | buy |
| Vinva Investment Management Ltd | 0 | 14,594 | +14,594 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 12,225 | +12,225 | 0.00 | 0.03 | +0.03 | buy |
| NEOS Investment Management LLC | 51,855 | 63,663 | +11,808 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 51,855 | 63,663 | +11,808 | 0.17 | 0.09 | -0.08 | buy |
| Hillsdale Investment Management Inc. | 205,022 | 216,422 | +11,400 | 0.09 | 0.11 | +0.02 | buy |
| Ewing Morris & Co. Investment Partners Ltd. | 0 | 10,850 | +10,850 | 0.00 | 0.08 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 166,428 | 176,634 | +10,206 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 100 | 6,868 | +6,768 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,947 | 11,301 | +6,354 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,307 | 15,460 | +5,153 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 8,671 | 13,624 | +4,953 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 133,090 | 137,552 | +4,462 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 89,371 | 93,657 | +4,286 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 10,628 | 14,518 | +3,890 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 34,293 | 37,583 | +3,290 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 2,981 | +2,981 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,942 | +2,942 | 0.00 | 0.01 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 69,730 | 72,530 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,669 | 14,205 | +2,536 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 25,389 | 27,314 | +1,925 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27,109 | 29,015 | +1,906 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 54,075 | 55,975 | +1,900 | 0.00 | 0.01 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 1,510 | +1,510 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,178 | 8,686 | +1,508 | 0.03 | 0.04 | +0.01 | buy |
| HSBC HOLDINGS PLC | 36,497 | 37,600 | +1,103 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 182,270 | 182,847 | +577 | 0.00 | 0.01 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 41,224 | 41,768 | +544 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 472 | +472 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,110 | 3,514 | +404 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,692 | 2,906 | +214 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 211 | +211 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,544,763 | 1,544,898 | +135 | 0.01 | 0.01 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 472 | 549 | +77 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 73 | +73 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 7 | 58 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 25 | 62 | +37 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 26 | 53 | +27 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 45 | 64 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 122 | 140 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 29,040 | 29,050 | +10 | 0.01 | 0.01 | +0.00 | buy |
| Sterling Capital Management LLC | 119 | 121 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 10 | 12 | +2 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 181 | 182 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 5,000 | 5,001 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.70 | 0.72 | +0.03 | hold |
| JANUS HENDERSON GROUP PLC | 18,200 | 18,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 3,843 | 3,843 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 286 | 286 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 33,309 | 33,309 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 73,100 | 73,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 22,970,388 | 22,970,388 | 0 | 17.08 | 18.83 | +1.74 | hold |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 2.65 | 2.90 | +0.25 | hold |
| IFP Advisors, Inc | 96 | 96 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rubric Capital Management LP | 4,710,551 | 4,710,551 | 0 | 0.95 | 1.08 | +0.13 | hold |
| Parallel Advisors, LLC | 329 | 329 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TPG Financial Advisors, LLC | 10,017 | 10,017 | 0 | 0.05 | 0.06 | +0.01 | hold |
| KLP KAPITALFORVALTNING AS | 7,300 | 7,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 53 | 53 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Physician Wealth Advisors, Inc. | 51 | 51 | 0 | 0.00 | 0.00 | +0.00 | hold |