| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | 22,970,388 | 0 | 17.08 | 18.83 | +1.74 | hold |
| Rubric Capital Management LP | 4,710,551 | 4,710,551 | 0 | 0.95 | 1.08 | +0.13 | hold |
| BlackRock, Inc. | 3,794,272 | 3,989,533 | +195,261 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 4,177,614 | 3,984,585 | -193,029 | 0.00 | 0.00 | +0.00 | sell |
| BVF INC/IL | 4,308,935 | 3,938,641 | -370,294 | 1.93 | 2.73 | +0.80 | sell |
| Redmile Group, LLC | 4,150,627 | 3,705,750 | -444,877 | 5.54 | 6.16 | +0.61 | sell |
| VANGUARD GROUP INC | 2,464,693 | 2,154,434 | -310,259 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,275,274 | 2,090,663 | +815,389 | 0.60 | 1.03 | +0.43 | buy |
| Vestal Point Capital, LP | 1,150,000 | 1,765,000 | +615,000 | 0.76 | 1.37 | +0.61 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,459,513 | 1,710,463 | -749,050 | 0.01 | 0.01 | +0.00 | sell |
| Blackstone Inc. | 1,656,790 | 1,616,290 | -40,500 | 0.09 | 0.12 | +0.02 | sell |
| DEUTSCHE BANK AG\ | 1,544,763 | 1,544,898 | +135 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 492,780 | 1,326,774 | +833,994 | 0.01 | 0.03 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,192,432 | 1,190,838 | -1,594 | 0.00 | 0.00 | +0.00 | sell |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 2.65 | 2.90 | +0.25 | hold |
| MILLENNIUM MANAGEMENT LLC | 116,102 | 1,104,813 | +988,711 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.70 | 0.72 | +0.03 | hold |
| STATE STREET CORP | 1,088,459 | 1,081,189 | -7,270 | 0.00 | 0.00 | +0.00 | sell |
| Prosight Management, LP | 1,309,904 | 749,611 | -560,293 | 4.01 | 3.07 | -0.93 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 705,364 | 678,636 | -26,728 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 654,916 | 565,385 | -89,531 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 476,000 | 564,000 | +88,000 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 428,857 | 443,525 | +14,668 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 533,300 | 431,700 | -101,600 | 0.01 | 0.01 | +0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 369,499 | 350,660 | -18,839 | 0.04 | 0.05 | +0.01 | sell |
| NORTHERN TRUST CORP | 349,799 | 348,253 | -1,546 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 380,783 | 345,331 | -35,452 | 0.19 | 0.24 | +0.05 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 313,753 | +313,753 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 280,726 | 272,797 | -7,929 | 0.02 | 0.03 | +0.01 | sell |
| Qube Research & Technologies Ltd | 69,874 | 255,002 | +185,128 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 155,599 | 219,948 | +64,349 | 0.00 | 0.01 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 205,022 | 216,422 | +11,400 | 0.09 | 0.11 | +0.02 | buy |
| ALGERT GLOBAL LLC | 118,104 | 207,926 | +89,822 | 0.03 | 0.06 | +0.03 | buy |
| Samsara BioCapital, LLC | 310,300 | 207,901 | -102,399 | 0.80 | 0.46 | -0.33 | sell |
| CITADEL ADVISORS LLC | 246,155 | 206,858 | -39,297 | 0.00 | 0.00 | +0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 207,602 | 206,322 | -1,280 | 0.04 | 0.04 | +0.01 | sell |
| BARCLAYS PLC | 122,820 | 199,023 | +76,203 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 124,204 | 193,360 | +69,156 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 182,270 | 182,847 | +577 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 166,428 | 176,634 | +10,206 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 180,690 | 168,685 | -12,005 | 0.00 | 0.00 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 304,666 | 161,486 | -143,180 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 35,406 | 158,616 | +123,210 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 154,858 | +154,858 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 166,143 | 152,632 | -13,511 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 146,954 | 146,440 | -514 | 0.04 | 0.06 | +0.01 | sell |
| JANE STREET GROUP, LLC | 12,549 | 145,206 | +132,657 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 133,090 | 137,552 | +4,462 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 255,291 | 126,923 | -128,368 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 238,391 | 124,784 | -113,607 | 0.20 | 0.14 | -0.06 | sell |
| RAYMOND JAMES FINANCIAL INC | 124,435 | 122,868 | -1,567 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 155,998 | 117,804 | -38,194 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 107,788 | +107,788 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 33,559 | 106,072 | +72,513 | 0.00 | 0.01 | +0.01 | buy |
| Opaleye Management Inc. | 210,000 | 100,000 | -110,000 | 0.53 | 0.24 | -0.29 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 96,800 | +96,800 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 89,371 | 93,657 | +4,286 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 86,083 | 85,902 | -181 | 0.00 | 0.00 | +0.00 | sell |
| Tejara Capital Ltd | 200,150 | 85,163 | -114,987 | 1.16 | 0.80 | -0.37 | sell |
| Susquehanna Portfolio Strategies, LLC | 85,728 | 84,195 | -1,533 | 0.02 | 0.02 | -0.00 | sell |
| North Growth Management Ltd. | 97,000 | 82,000 | -15,000 | 0.23 | 0.25 | +0.02 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 83,655 | 80,143 | -3,512 | 1.47 | 1.41 | -0.05 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 75,928 | +75,928 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 90,378 | 75,327 | -15,051 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 73,100 | 73,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 25,000 | 72,787 | +47,787 | 0.10 | 0.25 | +0.15 | buy |
| STIFEL FINANCIAL CORP | 69,730 | 72,530 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 71,979 | 71,974 | -5 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 32,758 | 68,461 | +35,703 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 51,855 | 63,663 | +11,808 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 51,855 | 63,663 | +11,808 | 0.17 | 0.09 | -0.08 | buy |
| ROYAL BANK OF CANADA | 72,983 | 57,925 | -15,058 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 28,312 | 57,448 | +29,136 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 21,355 | 56,377 | +35,022 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 18,941 | 56,318 | +37,377 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,035 | 56,274 | +34,239 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 54,075 | 55,975 | +1,900 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 259,137 | 52,054 | -207,083 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 251,510 | 51,841 | -199,669 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 31,147 | 51,016 | +19,869 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 41,224 | 41,768 | +544 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 46,300 | 40,900 | -5,400 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 36,497 | 37,600 | +1,103 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 34,293 | 37,583 | +3,290 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 96,989 | 37,167 | -59,822 | 0.05 | 0.02 | -0.03 | sell |
| OXFORD ASSET MANAGEMENT LLP | 0 | 36,359 | +36,359 | 0.00 | 0.20 | +0.20 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,873 | 35,231 | -7,642 | 0.00 | 0.00 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 34,610 | 34,510 | -100 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 441,690 | 33,884 | -407,806 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 0 | 33,821 | +33,821 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 44,965 | 33,390 | -11,575 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 33,309 | 33,309 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 32,757 | +32,757 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 14,985 | 32,493 | +17,508 | 0.01 | 0.04 | +0.03 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 32,170 | 31,237 | -933 | 0.00 | 0.00 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14,300 | 30,432 | +16,132 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 29,934 | 29,708 | -226 | 0.00 | 0.00 | +0.00 | sell |
| JOURNEY STRATEGIC WEALTH LLC | 29,040 | 29,050 | +10 | 0.01 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 27,109 | 29,015 | +1,906 | 0.00 | 0.00 | +0.00 | buy |