| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 2,651,394 | 3,475,384 | +823,990 | 0.71 | 1.35 | +0.64 | buy |
| DEUTSCHE BANK AG\ | 114,853 | 888,635 | +773,782 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 825,988 | 1,254,021 | +428,033 | 0.02 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 4,484,718 | 4,861,286 | +376,568 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 64,001 | 368,041 | +304,040 | 0.00 | 0.02 | +0.02 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,558,251 | 1,771,776 | +213,525 | 0.03 | 0.05 | +0.02 | buy |
| NORGES BANK | 0 | 201,700 | +201,700 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 139,415 | 276,899 | +137,484 | 0.00 | 0.00 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 136,819 | +136,819 | 0.00 | 0.27 | +0.27 | buy |
| CITADEL ADVISORS LLC | 37,006 | 173,573 | +136,567 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 5,661,230 | 5,790,230 | +129,000 | 1.71 | 2.15 | +0.44 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 122,926 | +122,926 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 93,329 | +93,329 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 937,102 | 1,007,812 | +70,710 | 0.00 | 0.00 | +0.00 | buy |
| AVIVA PLC | 0 | 69,386 | +69,386 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 17,922 | 82,474 | +64,552 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 56,363 | +56,363 | 0.00 | 0.44 | +0.44 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 4,000 | 56,323 | +52,323 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 156,682 | 205,246 | +48,564 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 46,770 | +46,770 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 191,630 | 238,246 | +46,616 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 124,548 | 168,700 | +44,152 | 0.01 | 0.02 | +0.01 | buy |
| Man Group plc | 0 | 42,769 | +42,769 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 599,463 | 639,672 | +40,209 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 0 | 40,000 | +40,000 | 0.00 | 0.02 | +0.02 | buy |
| Pennant Investors, LP | 0 | 38,700 | +38,700 | 0.00 | 0.12 | +0.12 | buy |
| Allspring Global Investments Holdings, LLC | 189,444 | 227,625 | +38,181 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 168,571 | 200,621 | +32,050 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 0 | 31,689 | +31,689 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 37,820 | 64,414 | +26,594 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 655,655 | 680,316 | +24,661 | 0.10 | 0.15 | +0.05 | buy |
| Empowered Funds, LLC | 248,755 | 273,416 | +24,661 | 0.05 | 0.07 | +0.02 | buy |
| LPL Financial LLC | 0 | 23,126 | +23,126 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 5,539 | 27,004 | +21,465 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 474,724 | 495,582 | +20,858 | 0.03 | 0.05 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 0 | 18,170 | +18,170 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 18,006 | +18,006 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 220,710 | 236,260 | +15,550 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,480 | 17,092 | +14,612 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 13,453 | +13,453 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 36,404 | 49,684 | +13,280 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 15,829 | 28,071 | +12,242 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,521 | 76,740 | +11,219 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,383,986 | 2,394,712 | +10,726 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Middle East FZE | 0 | 10,437 | +10,437 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,142 | +10,142 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 8,100 | +8,100 | 0.00 | 0.02 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 41,694 | 49,760 | +8,066 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 62,275 | 70,025 | +7,750 | 0.00 | 0.00 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 8,300 | 14,392 | +6,092 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 72,107 | 77,597 | +5,490 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 15,389 | 20,617 | +5,228 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 89,700 | 94,643 | +4,943 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 0 | 4,781 | +4,781 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,680 | 35,790 | +4,110 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,274 | 40,208 | +3,934 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 121,866 | 125,491 | +3,625 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,083 | 51,649 | +3,566 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 81,754 | 85,187 | +3,433 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 24,958 | 27,439 | +2,481 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,561 | 13,313 | +1,752 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 26,210 | 27,958 | +1,748 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 42,889 | 44,182 | +1,293 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,408 | 5,616 | +1,208 | 0.00 | 0.00 | +0.00 | buy |
| SummerHaven Investment Management, LLC | 86,310 | 87,509 | +1,199 | 0.40 | 0.58 | +0.18 | buy |
| FMR LLC | 24,712 | 25,593 | +881 | 0.00 | 0.00 | +0.00 | buy |
| Gladius Capital Management LP | 3,940 | 4,491 | +551 | 0.01 | 0.03 | +0.02 | buy |
| Robeco Institutional Asset Management B.V. | 0 | 536 | +536 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 398 | +398 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 10,049 | 10,429 | +380 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 26,639 | 26,966 | +327 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 286 | +286 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 1,398 | 1,535 | +137 | 0.00 | 0.00 | +0.00 | buy |
| Security National Bank | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 316 | 329 | +13 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 5,870,000 | 5,870,000 | 0 | 1.00 | 1.53 | +0.52 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 22,088 | 22,088 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARATHON CAPITAL MANAGEMENT | 20,250 | 20,250 | 0 | 0.03 | 0.05 | +0.02 | hold |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 375,848 | 375,848 | 0 | 0.02 | 0.03 | +0.01 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.98 | 1.06 | +0.07 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 409,839 | 409,839 | 0 | 0.10 | 0.17 | +0.07 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,439 | 12,439 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Asset Dedication, LLC | 47 | 47 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MetLife Investment Management, LLC | 28,898 | 28,898 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EcoR1 Capital, LLC | 13,437,473 | 13,437,473 | 0 | 2.90 | 3.62 | +0.72 | hold |
| Compagnie Lombard Odier SCmA | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 85,878 | 85,878 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 53 | 53 | 0 | 0.00 | 0.00 | +0.00 | hold |
| One Wealth Advisors, LLC | 12,121 | 12,121 | 0 | 0.02 | 0.02 | +0.01 | hold |
| Samsara BioCapital, LLC | 1,458,875 | 1,458,875 | 0 | 2.83 | 2.36 | -0.47 | hold |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.14 | 0.21 | +0.08 | hold |
| Global Retirement Partners, LLC | 905 | 905 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Stonehage Fleming Financial Services Holdings Ltd | 550 | 550 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Old Well Partners, LLC | 19,200 | 19,200 | 0 | 0.11 | 0.19 | +0.08 | hold |
| HighMark Wealth Management LLC | 280 | 280 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hunter Perkins Capital Management, LLC | 10,190 | 10,190 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Eagle Bay Advisors LLC | 110 | 110 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 28,846 | 28,846 | 0 | 0.01 | 0.01 | +0.01 | hold |