| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 13,437,473 | 15,028,079 | +1,590,606 | 5.77 | 8.79 | +3.01 | buy |
| Redmile Group, LLC | 5,101,911 | 4,840,463 | -261,448 | 3.77 | 4.94 | +1.17 | sell |
| BVF INC/IL | 4,607,935 | 4,308,935 | -299,000 | 1.69 | 2.14 | +0.45 | sell |
| MORGAN STANLEY | 5,106,869 | 4,201,437 | -905,432 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 4,263,595 | 4,184,956 | -78,639 | 0.00 | 0.00 | +0.00 | sell |
| Rubric Capital Management LP | 3,917,331 | 3,917,331 | 0 | 0.80 | 1.04 | +0.24 | hold |
| VANGUARD GROUP INC | 2,858,514 | 2,493,288 | -365,226 | 0.00 | 0.00 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,945,491 | 2,137,653 | +192,162 | 0.06 | 0.08 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 2,180,020 | 2,130,020 | -50,000 | 0.59 | 0.87 | +0.28 | sell |
| DEUTSCHE BANK AG\ | 1,528,923 | 1,546,772 | +17,849 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,524,084 | 1,365,111 | -158,973 | 0.00 | 0.00 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 1,361,000 | 1,329,974 | -31,026 | 0.09 | 0.10 | +0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.99 | 1.07 | +0.08 | hold |
| STATE STREET CORP | 1,171,777 | 1,084,961 | -86,816 | 0.00 | 0.00 | +0.00 | sell |
| Samsara BioCapital, LLC | 1,000,000 | 1,000,000 | 0 | 2.41 | 2.01 | -0.40 | hold |
| DIMENSIONAL FUND ADVISORS LP | 849,502 | 972,742 | +123,240 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 917,599 | 820,000 | -97,599 | 2.92 | 3.36 | +0.44 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 742,561 | 759,653 | +17,092 | 0.20 | 0.25 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 713,915 | 689,884 | -24,031 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 331,144 | 642,251 | +311,107 | 0.01 | 0.02 | +0.01 | buy |
| Blackstone Inc. | 25,082 | 569,715 | +544,633 | 0.00 | 0.04 | +0.04 | buy |
| Walleye Capital LLC | 0 | 452,804 | +452,804 | 0.00 | 0.06 | +0.06 | buy |
| Granahan Investment Management, LLC | 613,503 | 411,120 | -202,383 | 0.30 | 0.25 | -0.05 | sell |
| NORTHERN TRUST CORP | 370,927 | 394,830 | +23,903 | 0.00 | 0.00 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 426,944 | 369,499 | -57,445 | 0.05 | 0.05 | +0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 522,640 | 356,168 | -166,472 | 0.03 | 0.02 | -0.01 | sell |
| Empowered Funds, LLC | 335,661 | 352,753 | +17,092 | 0.07 | 0.08 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 337,161 | +337,161 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 49,583 | 330,127 | +280,544 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 327,522 | 306,460 | -21,062 | 0.19 | 0.26 | +0.08 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 184,600 | 285,700 | +101,100 | 0.00 | 0.01 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 285,115 | 282,345 | -2,770 | 0.02 | 0.03 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 251,477 | 249,960 | -1,517 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 445,776 | 230,970 | -214,806 | 0.02 | 0.01 | -0.01 | sell |
| Hillsdale Investment Management Inc. | 0 | 230,025 | +230,025 | 0.00 | 0.17 | +0.17 | buy |
| BARCLAYS PLC | 154,384 | 220,890 | +66,506 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 243,189 | 219,098 | -24,091 | 0.00 | 0.00 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 100,866 | 214,338 | +113,472 | 0.01 | 0.01 | +0.01 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 244,656 | 206,569 | -38,087 | 0.12 | 0.09 | -0.03 | sell |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vestal Point Capital, LP | 615,000 | 185,000 | -430,000 | 0.61 | 0.16 | -0.45 | sell |
| FEDERATED HERMES, INC. | 178,259 | 181,626 | +3,367 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 135,555 | 166,896 | +31,341 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 177,410 | 164,058 | -13,352 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 143,580 | 139,953 | -3,627 | 0.04 | 0.05 | +0.01 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 144,848 | 132,577 | -12,271 | 0.02 | 0.02 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,798 | 131,306 | -1,492 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 137,326 | 121,526 | -15,800 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 249,991 | 120,683 | -129,308 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 39,280 | 111,983 | +72,703 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 87,956 | 103,876 | +15,920 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 101,996 | +101,996 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 59,523 | 97,553 | +38,030 | 0.01 | 0.02 | +0.01 | buy |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.23 | 0.27 | +0.04 | hold |
| HRT FINANCIAL LP | 48,808 | 95,974 | +47,166 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 90,200 | 90,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 79,890 | 83,136 | +3,246 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 70,169 | 74,466 | +4,297 | 0.03 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 163,039 | 69,382 | -93,657 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 67,240 | +67,240 | 0.00 | 0.99 | +0.99 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 85,158 | 65,381 | -19,777 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 73,654 | 64,330 | -9,324 | 0.00 | 0.00 | +0.00 | sell |
| Fisher Asset Management, LLC | 63,600 | 63,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROYAL BANK OF CANADA | 61,878 | 60,926 | -952 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 19,342 | 59,514 | +40,172 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 20,808 | 58,358 | +37,550 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 65,678 | 54,090 | -11,588 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 54,390 | 51,580 | -2,810 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,386 | 51,516 | +35,130 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 60,983 | 50,583 | -10,400 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 0 | 49,000 | +49,000 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 48,612 | +48,612 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 39,571 | 47,082 | +7,511 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 49,771 | 44,945 | -4,826 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,166 | 43,783 | -383 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 43,708 | +43,708 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 39,942 | +39,942 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 0 | 38,537 | +38,537 | 0.00 | 0.37 | +0.37 | buy |
| Polar Asset Management Partners Inc. | 0 | 36,000 | +36,000 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 31,893 | 33,946 | +2,053 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 21,160 | 33,858 | +12,698 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 33,702 | +33,702 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 69,730 | 31,700 | -38,030 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,666 | 30,960 | +4,294 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,665 | 30,958 | +293 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 39,389 | 30,806 | -8,583 | 0.00 | 0.00 | +0.00 | sell |
| JOURNEY STRATEGIC WEALTH LLC | 28,897 | 28,897 | 0 | 0.01 | 0.02 | +0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 79,856 | 27,385 | -52,471 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 29,878 | 27,115 | -2,763 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 20,543 | 26,782 | +6,239 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,862 | 26,074 | +1,212 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 28,585 | 25,948 | -2,637 | 0.00 | 0.00 | +0.00 | sell |
| JANE STREET GROUP, LLC | 80,326 | 23,127 | -57,199 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 22,800 | +22,800 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,336 | 21,966 | +18,630 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 21,868 | +21,868 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,348 | 21,583 | +3,235 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,047 | 20,958 | -1,089 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 21,782 | 20,840 | -942 | 0.00 | 0.00 | -0.00 | sell |