| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 13,437,473 | 15,028,079 | +1,590,606 | 5.77 | 8.32 | +2.55 | buy |
| Blackstone Inc. | 25,082 | 569,715 | +544,633 | 0.00 | 0.04 | +0.04 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,945,491 | 2,137,653 | +192,162 | 0.06 | 0.08 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 742,561 | 759,653 | +17,092 | 0.20 | 0.25 | 0.00 | buy |
| Empowered Funds, LLC | 335,661 | 352,753 | +17,092 | 0.07 | 0.08 | +0.01 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 70,169 | 74,466 | +4,297 | 0.03 | 0.03 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 13,665 | 14,605 | +940 | 0.02 | 0.02 | +0.00 | buy |
| Truvestments Capital LLC | 259 | 434 | +175 | 0.00 | 0.00 | 0.00 | buy |
| Northwest & Ethical Investments L.P. | 6,371 | 5,471 | -900 | 0.00 | 0.00 | +0.00 | sell |
| TPG Financial Advisors, LLC | 11,017 | 10,017 | -1,000 | 0.06 | 0.06 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 285,115 | 282,345 | -2,770 | 0.02 | 0.03 | +0.00 | sell |
| Compagnie Lombard Odier SCmA | 10,000 | 7,000 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 143,580 | 139,953 | -3,627 | 0.04 | 0.05 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 10,114 | 5,633 | -4,481 | 0.06 | 0.03 | -0.03 | sell |
| One Wealth Advisors, LLC | 24,345 | 13,979 | -10,366 | 0.05 | 0.03 | -0.02 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 144,848 | 132,577 | -12,271 | 0.02 | 0.02 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 327,522 | 306,460 | -21,062 | 0.19 | 0.26 | +0.08 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 244,656 | 206,569 | -38,087 | 0.10 | 0.06 | -0.04 | sell |
| PERCEPTIVE ADVISORS LLC | 2,180,020 | 2,130,020 | -50,000 | 0.58 | 0.86 | +0.28 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 79,856 | 27,385 | -52,471 | 0.00 | 0.00 | -0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 426,944 | 369,499 | -57,445 | 0.05 | 0.05 | +0.01 | sell |
| Prosight Management, LP | 917,599 | 820,000 | -97,599 | 2.83 | 3.32 | +0.48 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 522,640 | 356,168 | -166,472 | 0.03 | 0.02 | -0.01 | sell |
| Granahan Investment Management, LLC | 613,503 | 411,120 | -202,383 | 0.30 | 0.25 | -0.05 | sell |
| Redmile Group, LLC | 5,101,911 | 4,840,463 | -261,448 | 3.77 | 4.94 | +1.17 | sell |
| Monaco Asset Management SAM | 300,000 | 15,000 | -285,000 | 1.58 | 0.10 | -1.48 | sell |
| BVF INC/IL | 4,607,935 | 4,308,935 | -299,000 | 1.69 | 2.14 | +0.45 | sell |
| Vestal Point Capital, LP | 615,000 | 185,000 | -430,000 | 0.61 | 0.16 | -0.45 | sell |