| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 13,437,473 | 15,028,079 | +1,590,606 | 5.77 | 8.79 | +3.01 | buy |
| Blackstone Inc. | 25,082 | 569,715 | +544,633 | 0.00 | 0.04 | +0.04 | buy |
| Walleye Capital LLC | 0 | 452,804 | +452,804 | 0.00 | 0.06 | +0.06 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 337,161 | +337,161 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 331,144 | 642,251 | +311,107 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 49,583 | 330,127 | +280,544 | 0.00 | 0.01 | +0.01 | buy |
| Hillsdale Investment Management Inc. | 0 | 230,025 | +230,025 | 0.00 | 0.17 | +0.17 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,945,491 | 2,137,653 | +192,162 | 0.06 | 0.08 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 849,502 | 972,742 | +123,240 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 100,866 | 214,338 | +113,472 | 0.01 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 101,996 | +101,996 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 184,600 | 285,700 | +101,100 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 39,280 | 111,983 | +72,703 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 67,240 | +67,240 | 0.00 | 0.99 | +0.99 | buy |
| BARCLAYS PLC | 154,384 | 220,890 | +66,506 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 49,000 | +49,000 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 48,612 | +48,612 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 48,808 | 95,974 | +47,166 | 0.00 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 43,708 | +43,708 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,342 | 59,514 | +40,172 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 39,942 | +39,942 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 0 | 38,537 | +38,537 | 0.00 | 0.37 | +0.37 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 59,523 | 97,553 | +38,030 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 20,808 | 58,358 | +37,550 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 36,000 | +36,000 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,386 | 51,516 | +35,130 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 33,702 | +33,702 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 135,555 | 166,896 | +31,341 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 370,927 | 394,830 | +23,903 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 22,800 | +22,800 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 21,868 | +21,868 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 19,660 | +19,660 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,336 | 21,966 | +18,630 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,528,923 | 1,546,772 | +17,849 | 0.01 | 0.01 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 742,561 | 759,653 | +17,092 | 0.20 | 0.25 | +0.05 | buy |
| Empowered Funds, LLC | 335,661 | 352,753 | +17,092 | 0.07 | 0.08 | +0.01 | buy |
| RHUMBLINE ADVISERS | 87,956 | 103,876 | +15,920 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 15,814 | +15,814 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 21,160 | 33,858 | +12,698 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,186 | 9,704 | +7,518 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 39,571 | 47,082 | +7,511 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 7,363 | +7,363 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 20,543 | 26,782 | +6,239 | 0.00 | 0.00 | +0.00 | buy |
| RITHOLTZ WEALTH MANAGEMENT | 70,169 | 74,466 | +4,297 | 0.03 | 0.03 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 26,666 | 30,960 | +4,294 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,371 | 13,371 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 178,259 | 181,626 | +3,367 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 79,890 | 83,136 | +3,246 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,348 | 21,583 | +3,235 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,082 | 19,611 | +2,529 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 484 | 2,808 | +2,324 | 0.00 | 0.01 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,527 | 13,743 | +2,216 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 31,893 | 33,946 | +2,053 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 195 | 1,719 | +1,524 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,862 | 26,074 | +1,212 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,665 | 14,605 | +940 | 0.02 | 0.02 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 589 | +589 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,665 | 30,958 | +293 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,234 | 13,412 | +178 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 259 | 434 | +175 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 72 | 193 | +121 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 142 | 243 | +101 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 433 | 533 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 52 | +52 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 18 | 27 | +9 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,616 | 5,616 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SHELL ASSET MANAGEMENT CO | 12,357 | 12,357 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 1,100,000 | 0 | 0.99 | 1.07 | +0.08 | hold |
| JANUS HENDERSON GROUP PLC | 18,200 | 18,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Janney Montgomery Scott LLC | 10,267 | 10,267 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORGES BANK | 201,700 | 201,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 3,843 | 3,843 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 13,386 | 13,386 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 286 | 286 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Allworth Financial LP | 34 | 34 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Swiss National Bank | 90,200 | 90,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rubric Capital Management LP | 3,917,331 | 3,917,331 | 0 | 0.80 | 1.04 | +0.24 | hold |
| Parallel Advisors, LLC | 329 | 329 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 53 | 53 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 1,000,000 | 1,000,000 | 0 | 2.41 | 2.01 | -0.40 | hold |
| North Growth Management Ltd. | 97,000 | 97,000 | 0 | 0.23 | 0.27 | +0.04 | hold |
| HighMark Wealth Management LLC | 280 | 280 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cornerstone Planning Group LLC | 161 | 161 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Eagle Bay Advisors LLC | 110 | 110 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CoreCap Advisors, LLC | 18 | 18 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JOURNEY STRATEGIC WEALTH LLC | 28,897 | 28,897 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Farther Finance Advisors, LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 311 | 311 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JAMES INVESTMENT RESEARCH, INC. | 10,578 | 10,578 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Clearstead Advisors, LLC | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fisher Asset Management, LLC | 63,600 | 63,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,799 | 1,799 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15,340 | 15,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 60 | 50 | -10 | 0.00 | 0.00 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |