| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 22,970,388 | 22,970,388 | 0 | 18.83 | 27.61 | +8.78 | hold |
| Rubric Capital Management LP | 4,710,551 | 5,750,000 | +1,039,449 | 1.08 | 1.81 | +0.73 | buy |
| BlackRock, Inc. | 3,989,533 | 4,595,548 | +606,015 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 3,938,641 | 3,938,641 | 0 | 2.73 | 3.49 | +0.76 | hold |
| PERCEPTIVE ADVISORS LLC | 2,090,663 | 3,261,850 | +1,171,187 | 1.03 | 1.57 | +0.54 | buy |
| MORGAN STANLEY | 3,984,585 | 2,593,080 | -1,391,505 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 2,154,434 | 2,328,727 | +174,293 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,822,048 | +1,822,048 | 0.00 | 0.06 | +0.06 | buy |
| Siren, L.L.C. | 0 | 1,680,121 | +1,680,121 | 0.00 | 1.32 | +1.32 | buy |
| DEUTSCHE BANK AG\ | 1,544,898 | 1,595,833 | +50,935 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,190,838 | 1,159,215 | -31,623 | 0.00 | 0.01 | +0.00 | sell |
| Nextech Invest, Ltd. | 1,113,946 | 1,113,946 | 0 | 2.90 | 2.84 | -0.06 | hold |
| STATE STREET CORP | 1,081,189 | 1,037,642 | -43,547 | 0.00 | 0.00 | +0.00 | sell |
| Capricorn Fund Managers Ltd | 0 | 1,022,840 | +1,022,840 | 0.00 | 6.49 | +6.49 | buy |
| Vestal Point Capital, LP | 1,765,000 | 865,000 | -900,000 | 1.37 | 0.84 | -0.53 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 313,753 | 700,002 | +386,249 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 564,000 | 663,546 | +99,546 | 0.02 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 565,385 | 648,326 | +82,941 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 678,636 | 647,970 | -30,666 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 1,326,774 | 647,374 | -679,400 | 0.03 | 0.03 | -0.01 | sell |
| FMR LLC | 3,514 | 560,086 | +556,572 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 749,611 | 530,393 | -219,218 | 3.07 | 2.89 | -0.19 | sell |
| Redmile Group, LLC | 3,705,750 | 491,654 | -3,214,096 | 6.16 | 0.95 | -5.20 | sell |
| Qube Research & Technologies Ltd | 255,002 | 474,290 | +219,288 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 207,926 | 423,646 | +215,720 | 0.06 | 0.17 | +0.11 | buy |
| GOLDMAN SACHS GROUP INC | 443,525 | 420,207 | -23,318 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,104,813 | 381,621 | -723,192 | 0.01 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,710,463 | 320,261 | -1,390,202 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 348,253 | 307,979 | -40,274 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 107,788 | 288,571 | +180,783 | 0.01 | 0.04 | +0.03 | buy |
| UBS Group AG | 51,841 | 278,854 | +227,013 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 93,657 | 257,580 | +163,923 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 206,858 | 255,351 | +48,493 | 0.00 | 0.00 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 206,322 | 244,798 | +38,476 | 0.04 | 0.07 | +0.03 | buy |
| Hillsdale Investment Management Inc. | 216,422 | 237,922 | +21,500 | 0.11 | 0.17 | +0.06 | buy |
| Granahan Investment Management, LLC | 345,331 | 224,408 | -120,923 | 0.24 | 0.25 | +0.01 | sell |
| SummitTX Capital, L.P. | 0 | 224,268 | +224,268 | 0.00 | 0.18 | +0.18 | buy |
| D. E. Shaw & Co., Inc. | 126,923 | 223,786 | +96,863 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 193,360 | 220,909 | +27,549 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 431,700 | 220,877 | -210,823 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 176,634 | 208,313 | +31,679 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 122,868 | 187,685 | +64,817 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 272,797 | 181,790 | -91,007 | 0.03 | 0.03 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 168,685 | 181,705 | +13,020 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 52,054 | 176,088 | +124,034 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 182,847 | 152,689 | -30,158 | 0.01 | 0.01 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 146,440 | 145,534 | -906 | 0.06 | 0.08 | +0.03 | sell |
| Bank of New York Mellon Corp | 137,552 | 128,131 | -9,421 | 0.00 | 0.00 | +0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 350,660 | 125,506 | -225,154 | 0.05 | 0.03 | -0.02 | sell |
| HRT FINANCIAL LP | 68,461 | 121,064 | +52,603 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 75,928 | 113,141 | +37,213 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 117,804 | 111,207 | -6,597 | 0.00 | 0.00 | +0.00 | sell |
| Opaleye Management Inc. | 100,000 | 108,929 | +8,929 | 0.24 | 0.38 | +0.14 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 124,784 | 105,184 | -19,600 | 0.14 | 0.64 | +0.50 | sell |
| Trexquant Investment LP | 0 | 101,274 | +101,274 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.11 | +0.11 | buy |
| Susquehanna Portfolio Strategies, LLC | 84,195 | 99,795 | +15,600 | 0.02 | 0.04 | +0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 161,486 | 97,907 | -63,579 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 93,469 | +93,469 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 152,632 | 91,075 | -61,557 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 75,327 | 89,524 | +14,197 | 0.00 | 0.00 | +0.00 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 88,800 | +88,800 | 0.00 | 0.05 | +0.05 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 80,143 | 80,143 | 0 | 1.41 | 1.43 | +0.02 | hold |
| BARCLAYS PLC | 199,023 | 79,966 | -119,057 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 106,072 | 78,336 | -27,736 | 0.01 | 0.01 | +0.00 | sell |
| NEOS Investment Management LLC | 63,663 | 77,115 | +13,452 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 63,663 | 75,975 | +12,312 | 0.09 | 0.16 | +0.06 | buy |
| STIFEL FINANCIAL CORP | 72,530 | 75,847 | +3,317 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 56,274 | 75,566 | +19,292 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 85,902 | 75,498 | -10,404 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 158,616 | 75,318 | -83,298 | 0.01 | 0.00 | -0.00 | sell |
| Swiss National Bank | 73,100 | 74,200 | +1,100 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 73,627 | +73,627 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 145,206 | 70,445 | -74,761 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 71,974 | 68,197 | -3,777 | 0.00 | 0.00 | +0.00 | sell |
| Penserra Capital Management LLC | 0 | 60,146 | +60,146 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 33,821 | 58,987 | +25,166 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 51,016 | 58,832 | +7,816 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 57,448 | 58,350 | +902 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 57,925 | 55,055 | -2,870 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 50,030 | 50,030 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Dana Investment Advisors, Inc. | 0 | 48,318 | +48,318 | 0.00 | 0.04 | +0.04 | buy |
| SIMPLEX TRADING, LLC | 28,761 | 48,040 | +19,279 | 0.01 | 0.04 | +0.02 | buy |
| MACKENZIE FINANCIAL CORP | 56,377 | 45,460 | -10,917 | 0.00 | 0.00 | +0.00 | sell |
| North Growth Management Ltd. | 82,000 | 45,000 | -37,000 | 0.25 | 0.19 | -0.06 | sell |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 41,768 | 43,052 | +1,284 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 34,510 | 42,905 | +8,395 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,574 | 40,812 | +26,238 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,231 | 37,761 | +2,530 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 33,884 | 35,008 | +1,124 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 34,631 | -1,065,369 | 0.72 | 0.05 | -0.68 | sell |
| Campbell & CO Investment Adviser LLC | 32,493 | 33,588 | +1,095 | 0.04 | 0.04 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 30,432 | 32,815 | +2,383 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 28,369 | 32,149 | +3,780 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 31,415 | +31,415 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 37,583 | 30,324 | -7,259 | 0.00 | 0.00 | +0.00 | sell |
| JOURNEY STRATEGIC WEALTH LLC | 29,050 | 29,050 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Quantinno Capital Management LP | 0 | 28,883 | +28,883 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,816 | 28,784 | +1,968 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,309 | 28,630 | -4,679 | 0.00 | 0.00 | +0.00 | sell |