| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,090,663 | 3,261,850 | +1,171,187 | 1.03 | 1.53 | +0.50 | buy |
| Rubric Capital Management LP | 4,710,551 | 5,750,000 | +1,039,449 | 0.91 | 1.81 | +0.90 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 564,000 | 663,546 | +99,546 | 0.02 | 0.03 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 161,486 | 97,907 | +63,579 | 0.00 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 216,422 | 237,922 | +21,500 | 0.11 | 0.17 | +0.06 | buy |
| Susquehanna Portfolio Strategies, LLC | 84,195 | 99,795 | +15,600 | 0.02 | 0.04 | +0.02 | buy |
| NEOS Investment Management LLC | 63,663 | 77,115 | +13,452 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 63,663 | 75,975 | +12,312 | 0.09 | 0.16 | +0.06 | buy |
| Opaleye Management Inc. | 100,000 | 108,929 | +8,929 | 0.24 | 0.38 | +0.14 | buy |
| Northwest & Ethical Investments L.P. | 10,030 | 12,044 | +2,014 | 0.00 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,686 | 10,441 | +1,755 | 0.04 | 0.07 | +0.03 | buy |
| JAMES INVESTMENT RESEARCH, INC. | 10,578 | 10,925 | +347 | 0.02 | 0.03 | +0.01 | buy |
| HighMark Wealth Management LLC | 280 | 230 | -50 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,617 | 1,470 | -147 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 146,440 | 145,534 | -906 | 0.06 | 0.08 | +0.03 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 29,015 | 28,083 | -932 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,176 | 12,195 | -981 | 0.02 | 0.02 | +0.01 | sell |
| Vinva Investment Management Ltd | 14,594 | 12,216 | -2,378 | 0.01 | 0.01 | -0.00 | sell |
| STRS OHIO | 40,900 | 26,600 | -14,300 | 0.00 | 0.00 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 124,784 | 105,184 | -19,600 | 0.14 | 0.64 | +0.50 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 55,975 | 27,935 | -28,040 | 0.01 | 0.00 | -0.00 | sell |
| North Growth Management Ltd. | 82,000 | 45,000 | -37,000 | 0.25 | 0.19 | -0.06 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 272,797 | 181,790 | -91,007 | 0.03 | 0.03 | +0.00 | sell |
| Granahan Investment Management, LLC | 345,331 | 224,408 | -120,923 | 0.24 | 0.25 | +0.01 | sell |
| Prosight Management, LP | 749,611 | 530,393 | -219,218 | 2.99 | 2.89 | -0.10 | sell |
| JUPITER ASSET MANAGEMENT LTD | 350,660 | 125,506 | -225,154 | 0.05 | 0.03 | -0.02 | sell |
| Vestal Point Capital, LP | 1,765,000 | 865,000 | -900,000 | 1.37 | 0.84 | -0.53 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,100,000 | 34,631 | -1,065,369 | 0.72 | 0.05 | -0.68 | sell |
| Redmile Group, LLC | 3,705,750 | 491,654 | -3,214,096 | 6.16 | 0.95 | -5.20 | sell |