| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BALYASNY ASSET MANAGEMENT L.P. | 877,846 | 3,061,668 | +2,183,822 | 0.01 | 0.06 | +0.05 | buy |
| Point72 Asset Management, L.P. | 0 | 2,140,664 | +2,140,664 | 0.00 | 0.04 | +0.04 | buy |
| MPM BioImpact LLC | 0 | 1,936,291 | +1,936,291 | 0.00 | 1.36 | +1.36 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,793,190 | +1,793,190 | 0.00 | 0.32 | +0.32 | buy |
| Cormorant Asset Management, LP | 2,897,857 | 3,978,229 | +1,080,372 | 1.01 | 2.34 | +1.33 | buy |
| Octagon Capital Advisors LP | 0 | 934,716 | +934,716 | 0.00 | 0.99 | +0.99 | buy |
| ADAR1 Capital Management, LLC | 117,909 | 1,017,805 | +899,896 | 0.05 | 0.55 | +0.50 | buy |
| BRAIDWELL LP | 0 | 795,214 | +795,214 | 0.00 | 0.34 | +0.34 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 718,747 | +718,747 | 0.00 | 0.11 | +0.11 | buy |
| Casdin Capital, LLC | 538,461 | 1,250,000 | +711,539 | 0.28 | 0.72 | +0.44 | buy |
| Soleus Capital Management, L.P. | 0 | 405,523 | +405,523 | 0.00 | 0.16 | +0.16 | buy |
| Freestone Grove Partners LP | 0 | 397,446 | +397,446 | 0.00 | 0.03 | +0.03 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 258,390 | +258,390 | 0.00 | 0.70 | +0.70 | buy |
| Woodline Partners LP | 209,259 | 455,733 | +246,474 | 0.01 | 0.02 | +0.01 | buy |
| DAFNA Capital Management LLC | 0 | 239,553 | +239,553 | 0.00 | 0.53 | +0.53 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 414,852 | 552,501 | +137,649 | 2.05 | 4.01 | +1.96 | buy |
| MILLENNIUM MANAGEMENT LLC | 681,775 | 807,832 | +126,057 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 67,951 | +67,951 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 47,596 | +47,596 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 35,506 | +35,506 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 31,705 | +31,705 | 0.00 | 0.08 | +0.08 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 66,000 | 94,100 | +28,100 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 24,257 | +24,257 | 0.00 | 0.21 | +0.21 | buy |
| Verition Fund Management LLC | 0 | 17,594 | +17,594 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 11,133 | 14,174 | +3,041 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 577 | +577 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 91 | 91 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 538,461 | 538,461 | 0 | 0.01 | 0.01 | +0.00 | hold |
| VR Adviser, LLC | 3,212,731 | 3,212,731 | 0 | 0.83 | 1.12 | +0.29 | hold |
| Ikarian Capital, LLC | 33,899 | 33,899 | 0 | 0.03 | 0.06 | +0.03 | hold |
| ANTIPODES PARTNERS Ltd | 2,051 | 1,642 | -409 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 4,794 | 0 | -4,794 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 164,748 | 153,847 | -10,901 | 0.07 | 0.09 | +0.02 | sell |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 15,000 | 0 | -15,000 | 0.02 | 0.00 | -0.02 | sell |
| Tidal Investments LLC | 66,034 | 44,354 | -21,680 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 120,156 | 86,700 | -33,456 | 0.00 | 0.00 | +0.00 | sell |
| Persistent Asset Partners Ltd | 33,732 | 0 | -33,732 | 0.09 | 0.00 | -0.09 | sell |
| TD ASSET MANAGEMENT INC | 35,746 | 0 | -35,746 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 40,310 | 0 | -40,310 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 122,261 | 52,895 | -69,366 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 99,843 | 0 | -99,843 | 0.00 | 0.00 | -0.00 | sell |