| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 913,034 | 2,042,467 | +1,129,433 | 0.02 | 0.02 | +0.00 | buy |
| BRAIDWELL LP | 0 | 834,183 | +834,183 | 0.00 | 0.43 | +0.43 | buy |
| CITADEL ADVISORS LLC | 161,284 | 987,204 | +825,920 | 0.00 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 0 | 625,000 | +625,000 | 0.00 | 0.18 | +0.18 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 619,922 | +619,922 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 436,042 | +436,042 | 0.00 | 0.53 | +0.53 | buy |
| FRANKLIN RESOURCES INC | 0 | 434,751 | +434,751 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 1,746,946 | 2,159,809 | +412,863 | 0.07 | 0.04 | -0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 398,980 | +398,980 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 394,880 | +394,880 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 493,827 | 808,827 | +315,000 | 0.26 | 0.17 | -0.09 | buy |
| Qube Research & Technologies Ltd | 20,490 | 262,113 | +241,623 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 516,761 | 684,880 | +168,119 | 2.49 | 1.36 | -1.13 | buy |
| Point72 Asset Management, L.P. | 56,127 | 220,403 | +164,276 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 29,197 | 192,016 | +162,819 | 0.01 | 0.05 | +0.04 | buy |
| MORGAN STANLEY | 66,237 | 225,083 | +158,846 | 0.00 | 0.00 | +0.00 | buy |
| SYQUANT CAPITAL SAS | 222,867 | 375,000 | +152,133 | 0.93 | 1.16 | +0.24 | buy |
| UBS Group AG | 62,746 | 182,415 | +119,669 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 44,238 | 151,228 | +106,990 | 0.01 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 65,608 | +65,608 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 14,447 | 61,605 | +47,158 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 39,949 | +39,949 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 39,733 | +39,733 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 24,960 | 56,391 | +31,431 | 0.02 | 0.01 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 29,504 | +29,504 | 0.00 | 0.10 | +0.10 | buy |
| Persistent Asset Partners Ltd | 0 | 25,604 | +25,604 | 0.00 | 0.11 | +0.11 | buy |
| XTX Topco Ltd | 23,023 | 43,096 | +20,073 | 0.01 | 0.01 | -0.00 | buy |
| ALPS ADVISORS INC | 46,539 | 58,019 | +11,480 | 0.01 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 5,319 | +5,319 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 19,000 | 23,577 | +4,577 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 0 | 3,237 | +3,237 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 2,975 | +2,975 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,400 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 58,925 | 61,224 | +2,299 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 28,894 | 31,021 | +2,127 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 67,753 | 69,502 | +1,749 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1 | 76 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 34,716 | 34,716 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DUPONT CAPITAL MANAGEMENT CORP | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MMCAP International Inc. SPC | 73,025 | 73,025 | 0 | 0.08 | 0.03 | -0.05 | hold |
| Vestcor Inc | 11,666 | 11,666 | 0 | 0.01 | 0.00 | -0.00 | hold |
| JANE STREET GROUP, LLC | 45,702 | 45,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Compagnie Lombard Odier SCmA | 105,455 | 105,455 | 0 | 0.03 | 0.02 | -0.02 | hold |
| Mint Tower Capital Management B.V. | 5,833 | 5,833 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Woodline Partners LP | 201,200 | 201,200 | 0 | 0.02 | 0.01 | -0.01 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 641,022 | 641,022 | 0 | 1.86 | 0.86 | -1.01 | hold |
| JONES FINANCIAL COMPANIES LLLP | 210 | 0 | -210 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 222 | 0 | -222 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 252 | 0 | -252 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 540 | 0 | -540 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 21,189 | 20,623 | -566 | 0.00 | 0.00 | -0.00 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 18,926 | 17,276 | -1,650 | 0.04 | 0.01 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 5,050 | 0 | -5,050 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 7,774 | 0 | -7,774 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 8,524 | 0 | -8,524 | 0.00 | 0.00 | -0.00 | sell |
| Koshinski Asset Management, Inc. | 8,937 | 0 | -8,937 | 0.01 | 0.00 | -0.01 | sell |
| Palumbo Wealth Management LLC | 13,711 | 0 | -13,711 | 0.09 | 0.00 | -0.09 | sell |
| AXQ CAPITAL, LP | 14,118 | 0 | -14,118 | 0.05 | 0.00 | -0.05 | sell |
| Centiva Capital, LP | 18,145 | 0 | -18,145 | 0.02 | 0.00 | -0.02 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 41,666 | 20,000 | -21,666 | 0.02 | 0.00 | -0.02 | sell |
| Quadrature Capital Ltd | 25,482 | 0 | -25,482 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 69,764 | 43,978 | -25,786 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 53,045 | 24,846 | -28,199 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 350,745 | 300,565 | -50,180 | 7.69 | 3.17 | -4.52 | sell |
| Simplify Asset Management Inc. | 66,667 | 0 | -66,667 | 0.03 | 0.00 | -0.03 | sell |
| JANE STREET GROUP, LLC | 90,161 | 11,258 | -78,903 | 0.00 | 0.00 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 98,339 | 0 | -98,339 | 1.86 | 0.00 | -1.86 | sell |
| Propel Bio Management, LLC | 122,223 | 0 | -122,223 | 2.07 | 0.00 | -2.07 | sell |
| Alyeska Investment Group, L.P. | 331,332 | 206,332 | -125,000 | 0.02 | 0.01 | -0.02 | sell |
| HRT FINANCIAL LP | 148,021 | 0 | -148,021 | 0.01 | 0.00 | -0.01 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,680,283 | 1,506,250 | -174,033 | 15.97 | 6.79 | -9.18 | sell |
| FOLKETRYGDFONDET | 319,556 | 0 | -319,556 | 0.15 | 0.00 | -0.15 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 430,000 | 0 | -430,000 | 0.19 | 0.00 | -0.19 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,345,728 | 540,056 | -805,672 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 833,209 | 0 | -833,209 | 0.03 | 0.00 | -0.03 | sell |