| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Pivotal bioVenture Partners Investment Advisor LLC | 1,737,696 | 2,300,774 | +563,078 | 19.95 | 35.43 | +15.48 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 0 | 322,500 | +322,500 | 0.00 | 1.58 | +1.58 | buy |
| Aberdeen Group plc | 1,009,424 | 1,253,119 | +243,695 | 0.03 | 0.05 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 0 | 131,332 | +131,332 | 0.00 | 0.01 | +0.01 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 125,000 | +125,000 | 0.00 | 2.76 | +2.76 | buy |
| Nan Fung Group Holdings Ltd | 436,378 | 514,702 | +78,324 | 6.34 | 7.99 | +1.64 | buy |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 0 | 12,322 | +12,322 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 11,959 | +11,959 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 28,980 | 39,634 | +10,654 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 13,565 | 23,832 | +10,267 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 16,744 | 23,052 | +6,308 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 108,842 | 112,965 | +4,123 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 10,000 | 14,100 | +4,100 | 0.00 | 0.01 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 0 | 399 | +399 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 35,616 | 35,616 | 0 | 0.00 | 0.00 | +0.00 | hold |
| OMERS ADMINISTRATION Corp | 11,666 | 11,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DUPONT CAPITAL MANAGEMENT CORP | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MMCAP International Inc. SPC | 73,525 | 73,525 | 0 | 0.06 | 0.09 | +0.03 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 41,666 | 41,666 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Vestcor Inc | 11,666 | 11,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 45,701 | 45,701 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mint Tower Capital Management B.V. | 18,333 | 18,333 | 0 | 0.03 | 0.05 | +0.03 | hold |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 21,896 | 18,646 | -3,250 | 0.02 | 0.02 | +0.00 | sell |
| GABELLI FUNDS LLC | 20,746 | 13,670 | -7,076 | 0.00 | 0.00 | -0.00 | sell |
| Compagnie Lombard Odier SCmA | 95,750 | 87,000 | -8,750 | 0.02 | 0.02 | -0.00 | sell |
| XTX Topco Ltd | 13,249 | 0 | -13,249 | 0.02 | 0.00 | -0.02 | sell |
| Sculptor Capital LP | 14,015 | 0 | -14,015 | 0.00 | 0.00 | -0.00 | sell |
| WHITEBOX ADVISORS LLC | 16,833 | 0 | -16,833 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 19,560 | 0 | -19,560 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 22,911 | 0 | -22,911 | 0.00 | 0.00 | -0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 33,937 | 684 | -33,253 | 0.00 | 0.00 | -0.00 | sell |
| Calamos Advisors LLC | 33,333 | 0 | -33,333 | 0.00 | 0.00 | -0.00 | sell |
| Greenland Capital Management LP | 50,100 | 0 | -50,100 | 0.05 | 0.00 | -0.05 | sell |