| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,356,179 | +1,356,179 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 516,761 | +516,761 | 0.00 | 1.89 | +1.89 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 493,827 | +493,827 | 0.00 | 0.18 | +0.18 | buy |
| Aberdeen Group plc | 1,253,119 | 1,746,946 | +493,827 | 0.04 | 0.05 | +0.02 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 322,500 | 641,022 | +318,522 | 0.82 | 1.81 | +0.99 | buy |
| Alyeska Investment Group, L.P. | 131,332 | 331,332 | +200,000 | 0.01 | 0.02 | +0.01 | buy |
| SYQUANT CAPITAL SAS | 0 | 192,722 | +192,722 | 0.00 | 0.47 | +0.47 | buy |
| FOLKETRYGDFONDET | 0 | 182,800 | +182,800 | 0.00 | 0.08 | +0.08 | buy |
| Propel Bio Management, LLC | 0 | 172,839 | +172,839 | 0.00 | 2.95 | +2.95 | buy |
| CITADEL ADVISORS LLC | 0 | 165,487 | +165,487 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 83,833 | 201,200 | +117,367 | 0.01 | 0.02 | +0.01 | buy |
| Simplify Asset Management Inc. | 0 | 98,765 | +98,765 | 0.00 | 0.03 | +0.03 | buy |
| Neo Ivy Capital Management | 0 | 54,771 | +54,771 | 0.00 | 0.40 | +0.40 | buy |
| ALPS ADVISORS INC | 0 | 46,947 | +46,947 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 45,773 | +45,773 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 43,914 | +43,914 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 38,535 | 63,951 | +25,416 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 24,444 | +24,444 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 15,641 | +15,641 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 13,042 | +13,042 | 0.00 | 0.02 | +0.02 | buy |
| Compagnie Lombard Odier SCmA | 97,000 | 107,300 | +10,300 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 29,436 | 36,061 | +6,625 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE ASSET MANAGEMENT LLC | 3,048 | 6,423 | +3,375 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,000 | 2,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 12,379 | 12,519 | +140 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 45,701 | 45,702 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 35,616 | 35,616 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GABELLI FUNDS LLC | 13,670 | 13,670 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DUPONT CAPITAL MANAGEMENT CORP | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 41,666 | 41,666 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vestcor Inc | 11,666 | 11,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 101,777 | 101,777 | 0 | 1.85 | 1.38 | -0.47 | hold |
| Nan Fung Group Holdings Ltd | 514,702 | 514,702 | 0 | 15.18 | 9.20 | -5.98 | hold |
| SBI Securities Co., Ltd. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 18,601 | 18,600 | -1 | 0.02 | 0.02 | +0.00 | sell |
| WOLVERINE ASSET MANAGEMENT LLC | 269 | 0 | -269 | 0.00 | 0.00 | -0.00 | sell |
| MMCAP International Inc. SPC | 73,525 | 73,025 | -500 | 0.06 | 0.06 | +0.00 | sell |
| NORTHERN TRUST CORP | 21,804 | 21,189 | -615 | 0.00 | 0.00 | +0.00 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 2,300,774 | 2,288,658 | -12,116 | 23.38 | 17.67 | -5.71 | sell |
| Mint Tower Capital Management B.V. | 18,333 | 5,833 | -12,500 | 0.02 | 0.01 | -0.01 | sell |
| UBS Group AG | 74,732 | 45,916 | -28,816 | 0.00 | 0.00 | -0.00 | sell |