| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1,781,715 | 2,852,371 | +1,070,656 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,600,000 | 2,214,967 | +614,967 | 0.79 | 1.33 | +0.54 | buy |
| ArrowMark Colorado Holdings LLC | 627,669 | 1,097,369 | +469,700 | 0.07 | 0.14 | +0.07 | buy |
| Eversept Partners, LP | 172,103 | 445,588 | +273,485 | 0.15 | 0.40 | +0.25 | buy |
| Catalio Capital Management, LP | 187,184 | 295,148 | +107,964 | 0.34 | 0.58 | +0.24 | buy |
| STATE STREET CORP | 211,506 | 266,200 | +54,694 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 44,067 | +44,067 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 11,956 | +11,956 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 11,599 | +11,599 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 348,760 | 357,156 | +8,396 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,006,558 | 1,014,110 | +7,552 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 18,245 | 25,298 | +7,053 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 511,220 | 517,606 | +6,386 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,200 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 476 | +476 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,596 | 8,986 | +390 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,117 | 1,411 | +294 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 273 | +273 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,982 | 8,163 | +181 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 128 | +128 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 6,417 | 6,500 | +83 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,562,942 | 1,562,942 | 0 | 0.24 | 0.24 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,608 | 1,608 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 1,158,000 | 1,158,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,144 | 1,144 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STONERIDGE INVESTMENT PARTNERS LLC | 10,955 | 10,955 | 0 | 0.03 | 0.07 | +0.04 | hold |
| NEA Management Company, LLC | 2,613,948 | 2,613,948 | 0 | 1.21 | 1.59 | +0.38 | hold |
| NVP Associates, LLC | 1,838,482 | 1,838,482 | 0 | 8.05 | 12.95 | +4.89 | hold |
| Rock Springs Capital Management LP | 878,667 | 878,667 | 0 | 0.27 | 0.40 | +0.12 | hold |
| Birchview Capital, LP | 16,500 | 16,500 | 0 | 0.11 | 0.11 | +0.00 | hold |
| Vivo Capital, LLC | 1,183,260 | 1,183,260 | 0 | 1.09 | 1.24 | +0.15 | hold |
| Fairmount Funds Management LLC | 1,892,806 | 1,892,806 | 0 | 1.54 | 2.32 | +0.78 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 736,645 | 736,645 | 0 | 4.07 | 4.71 | +0.64 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 4,911,539 | 4,911,539 | 0 | 9.81 | 9.97 | +0.16 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 111,605 | 111,605 | 0 | 0.80 | 1.05 | +0.25 | hold |
| Enavate Sciences GP, LLC | 3,761,359 | 3,761,359 | 0 | 22.12 | 22.39 | +0.26 | hold |
| Police & Firemen's Retirement System of New Jersey | 4,499 | 4,499 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,519 | 1,519 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 2,800 | 2,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 524 | 524 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 22,990 | 22,990 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| MRP Capital Investments, LLC | 35 | 0 | -35 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 226 | 131 | -95 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 7,640 | 7,529 | -111 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 10,225 | 10,087 | -138 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 210 | 0 | -210 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 35,944 | 35,188 | -756 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 12,104 | 10,810 | -1,294 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,660 | 116,140 | -2,520 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 979,323 | 975,906 | -3,417 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 124,246 | 120,238 | -4,008 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 33,790 | 28,132 | -5,658 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 23,939 | 16,160 | -7,779 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 171,940 | 164,035 | -7,905 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 17,045 | 0 | -17,045 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 42,174 | 23,957 | -18,217 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 29,839 | 7,267 | -22,572 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 56,039 | 31,757 | -24,282 | 0.03 | 0.02 | -0.01 | sell |
| RHUMBLINE ADVISERS | 38,942 | 11,514 | -27,428 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 38,400 | 0 | -38,400 | 0.00 | 0.00 | -0.00 | sell |
| M&T BANK CORP | 62,622 | 0 | -62,622 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 66,202 | 0 | -66,202 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 82,624 | 0 | -82,624 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 131,665 | 0 | -131,665 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 134,896 | 0 | -134,896 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,135,289 | 873,623 | -261,666 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 358,212 | 0 | -358,212 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 744,035 | 0 | -744,035 | 0.17 | 0.00 | -0.17 | sell |