| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,704,255 | 9,082,000 | +1,377,745 | 0.01 | 0.01 | -0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 5,037,854 | 5,037,854 | 0 | 25.90 | 10.76 | -15.14 | hold |
| NEA Management Company, LLC | 3,523,219 | 4,023,219 | +500,000 | 6.52 | 4.47 | -2.05 | buy |
| Enavate Sciences GP, LLC | 3,919,159 | 3,919,159 | 0 | 28.08 | 21.80 | -6.28 | hold |
| Monashee Investment Management LLC | 0 | 3,152,000 | +3,152,000 | 0.00 | 1.75 | +1.75 | buy |
| FEDERATED HERMES, INC. | 2,715,578 | 3,127,031 | +411,453 | 0.16 | 0.10 | -0.07 | buy |
| Polar Capital Holdings Plc | 1,057,609 | 2,548,444 | +1,490,835 | 0.18 | 0.22 | +0.04 | buy |
| Capital International Investors | 0 | 2,434,000 | +2,434,000 | 0.00 | 0.01 | +0.01 | buy |
| Fairmount Funds Management LLC | 2,209,025 | 2,359,025 | +150,000 | 6.11 | 3.33 | -2.77 | buy |
| BlackRock, Inc. | 1,767,518 | 2,037,548 | +270,030 | 0.00 | 0.00 | -0.00 | buy |
| NVP Associates, LLC | 1,838,482 | 1,838,482 | 0 | 26.16 | 20.40 | -5.75 | hold |
| Maven Securities LTD | 0 | 1,500,000 | +1,500,000 | 0.00 | 0.09 | +0.09 | buy |
| STATE STREET CORP | 438,294 | 1,470,923 | +1,032,629 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 855,334 | 1,246,053 | +390,719 | 0.01 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,135,935 | +1,135,935 | 0.00 | 2.62 | +2.62 | buy |
| ALLIANCEBERNSTEIN L.P. | 18,350 | 897,321 | +878,971 | 0.00 | 0.01 | +0.01 | buy |
| EcoR1 Capital, LLC | 789,500 | 789,500 | 0 | 1.31 | 0.66 | -0.65 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 193,153 | 667,070 | +473,917 | 0.01 | 0.03 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 751,161 | 658,909 | -92,252 | 0.60 | 0.34 | -0.26 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 588,393 | 655,785 | +67,392 | 0.00 | 0.00 | -0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 591,991 | 591,991 | 0 | 8.31 | 4.14 | -4.17 | hold |
| Woodline Partners LP | 0 | 590,525 | +590,525 | 0.00 | 0.04 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 0 | 524,066 | +524,066 | 0.00 | 2.51 | +2.51 | buy |
| Rock Springs Capital Management LP | 502,077 | 502,077 | 0 | 0.94 | 0.58 | -0.36 | hold |
| MARSHALL WACE, LLP | 7,100 | 501,928 | +494,828 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 49,160 | 476,818 | +427,658 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 47,160 | 388,347 | +341,187 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 130,698 | 381,461 | +250,763 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 69,495 | 367,405 | +297,910 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 369,248 | 357,266 | -11,982 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 0 | 331,730 | +331,730 | 0.00 | 0.93 | +0.93 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,100 | 275,056 | +259,956 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 250,000 | +250,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 213,193 | 224,402 | +11,209 | 0.00 | 0.00 | -0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 219,947 | +219,947 | 0.00 | 0.05 | +0.05 | buy |
| iA Global Asset Management Inc. | 0 | 215,830 | +215,830 | 0.00 | 0.06 | +0.06 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 214,334 | +214,334 | 0.00 | 0.72 | +0.72 | buy |
| Vestal Point Capital, LP | 0 | 200,000 | +200,000 | 0.00 | 0.11 | +0.11 | buy |
| NORTHERN TRUST CORP | 155,366 | 194,640 | +39,274 | 0.00 | 0.00 | -0.00 | buy |
| Monashee Investment Management LLC | 0 | 150,000 | +150,000 | 0.00 | 1.60 | +1.60 | buy |
| Maven Securities LTD | 0 | 150,000 | +150,000 | 0.00 | 0.17 | +0.17 | buy |
| Walleye Capital LLC | 0 | 125,232 | +125,232 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 187,968 | 113,479 | -74,489 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 0 | 107,016 | +107,016 | 0.00 | 0.15 | +0.15 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.13 | +0.13 | buy |
| MORGAN STANLEY | 128,335 | 93,396 | -34,939 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,678 | 85,005 | +71,327 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 80,730 | +80,730 | 0.00 | 0.93 | +0.93 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 133,439 | 77,493 | -55,946 | 0.02 | 0.01 | -0.01 | sell |
| Birchview Capital, LP | 0 | 70,000 | +70,000 | 0.00 | 0.78 | +0.78 | buy |
| Nuveen, LLC | 50,850 | 67,770 | +16,920 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 24,459 | 66,870 | +42,411 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 51,802 | 60,864 | +9,062 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 60,001 | +60,001 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 78,220 | 50,971 | -27,249 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 0 | 48,169 | +48,169 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 44,077 | 43,694 | -383 | 0.01 | 0.00 | -0.01 | sell |
| Squarepoint Ops LLC | 15,541 | 42,874 | +27,333 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 42,500 | +42,500 | 0.00 | 0.19 | +0.19 | buy |
| Burkehill Global Management, LP | 0 | 40,000 | +40,000 | 0.00 | 0.04 | +0.04 | buy |
| J. Goldman & Co LP | 0 | 36,797 | +36,797 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 50,636 | 33,697 | -16,939 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 31,600 | 31,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Voleon Capital Management LP | 10,187 | 29,612 | +19,425 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 34,377 | 29,610 | -4,767 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 27,532 | +27,532 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 21,946 | 26,813 | +4,867 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 25,749 | +25,749 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 21,726 | 25,109 | +3,383 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,416 | +21,416 | 0.00 | 0.02 | +0.02 | buy |
| Quantinno Capital Management LP | 0 | 21,126 | +21,126 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,221 | 20,814 | +10,593 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 12,183 | 19,311 | +7,128 | 0.01 | 0.01 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 12,781 | 19,266 | +6,485 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 18,640 | +18,640 | 0.00 | 0.01 | +0.01 | buy |
| ALLSTATE CORP | 0 | 18,223 | +18,223 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 9,127 | 17,638 | +8,511 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 16,845 | +16,845 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 16,645 | +16,645 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,701 | 15,819 | +118 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 8,400 | 15,523 | +7,123 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,780 | 14,386 | +5,606 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,314 | 13,526 | +212 | 0.04 | 0.02 | -0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 13,331 | +13,331 | 0.00 | 0.04 | +0.04 | buy |
| Scientech Research LLC | 0 | 12,952 | +12,952 | 0.00 | 0.21 | +0.21 | buy |
| MetLife Investment Management, LLC | 10,100 | 12,909 | +2,809 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 12,273 | 12,658 | +385 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 12,386 | +12,386 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 13,027 | 10,432 | -2,595 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 7,138 | 9,999 | +2,861 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 2,351 | 9,888 | +7,537 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 21,151 | 8,885 | -12,266 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 795 | 7,235 | +6,440 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 6,777 | +6,777 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,554 | 6,717 | +163 | 0.06 | 0.04 | -0.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,499 | 6,363 | +1,864 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,200 | 6,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,824 | 4,767 | -1,057 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 3,400 | 3,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,608 | 2,800 | +192 | 0.00 | 0.00 | -0.00 | buy |