| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FEDERATED HERMES, INC. | 1,158,000 | 1,861,838 | +703,838 | 0.02 | 0.03 | +0.01 | buy |
| FMR LLC | 2,852,371 | 3,323,534 | +471,163 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 293,785 | +293,785 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 210,625 | +210,625 | 0.00 | 1.35 | +1.35 | buy |
| NEA Management Company, LLC | 2,613,948 | 2,733,719 | +119,771 | 1.59 | 1.99 | +0.40 | buy |
| BlackRock, Inc. | 1,014,110 | 1,095,609 | +81,499 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 266,200 | 310,236 | +44,036 | 0.00 | 0.00 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 736,645 | 779,045 | +42,400 | 4.71 | 4.68 | -0.03 | buy |
| Novo Holdings A/S | 2,214,967 | 2,250,000 | +35,033 | 1.33 | 1.54 | +0.21 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 24,668 | +24,668 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 19,617 | +19,617 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 357,156 | 373,617 | +16,461 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 16,360 | +16,360 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 975,906 | 992,212 | +16,306 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 14,900 | +14,900 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 12,907 | +12,907 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 16,160 | 27,813 | +11,653 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 11,514 | 19,721 | +8,207 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 116,140 | 122,210 | +6,070 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 873,623 | 878,918 | +5,295 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 35,188 | 38,433 | +3,245 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 6,500 | 9,179 | +2,679 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,163 | 10,424 | +2,261 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 11,599 | 13,206 | +1,607 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,411 | 2,546 | +1,135 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 476 | 1,465 | +989 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 843 | +843 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 273 | 1,061 | +788 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 7,267 | 7,676 | +409 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 131 | 439 | +308 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 11,956 | 12,142 | +186 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 128 | 295 | +167 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 28 | 115 | +87 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 2 | 58 | +56 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 41 | 79 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,519 | 1,548 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,087 | 10,100 | +13 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,562,942 | 1,562,942 | 0 | 0.24 | 0.27 | +0.03 | hold |
| Ameritas Investment Partners, Inc. | 1,608 | 1,608 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,144 | 1,144 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NVP Associates, LLC | 1,838,482 | 1,838,482 | 0 | 12.95 | 9.67 | -3.27 | hold |
| Birchview Capital, LP | 16,500 | 16,500 | 0 | 0.11 | 0.16 | +0.05 | hold |
| Vivo Capital, LLC | 1,183,260 | 1,183,260 | 0 | 1.24 | 1.17 | -0.06 | hold |
| Fairmount Funds Management LLC | 1,892,806 | 1,892,806 | 0 | 2.32 | 2.38 | +0.06 | hold |
| Nuveen, LLC | 31,626 | 31,626 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 4,911,539 | 4,911,539 | 0 | 9.97 | 10.32 | +0.35 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 111,605 | 111,605 | 0 | 1.05 | 1.35 | +0.30 | hold |
| Enavate Sciences GP, LLC | 3,761,359 | 3,761,359 | 0 | 22.39 | 20.65 | -1.74 | hold |
| True Wealth Design, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 4,499 | 4,499 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,200 | 6,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 2,800 | 2,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 524 | 524 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,986 | 8,886 | -100 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 120,238 | 119,515 | -723 | 0.00 | 0.00 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 1,097,369 | 1,094,338 | -3,031 | 0.14 | 0.19 | +0.05 | sell |
| CITIGROUP INC | 10,810 | 5,451 | -5,359 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 28,132 | 22,553 | -5,579 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 7,529 | 0 | -7,529 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 164,035 | 154,916 | -9,119 | 0.00 | 0.00 | -0.00 | sell |
| STONERIDGE INVESTMENT PARTNERS LLC | 10,955 | 0 | -10,955 | 0.07 | 0.00 | -0.07 | sell |
| DEUTSCHE BANK AG\ | 22,990 | 280 | -22,710 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 25,298 | 1,430 | -23,868 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 23,957 | 0 | -23,957 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 31,757 | 0 | -31,757 | 0.02 | 0.00 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 517,606 | 485,202 | -32,404 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 44,067 | 0 | -44,067 | 0.01 | 0.00 | -0.01 | sell |
| Catalio Capital Management, LP | 295,148 | 215,314 | -79,834 | 0.58 | 0.44 | -0.14 | sell |
| Eversept Partners, LP | 445,588 | 325,479 | -120,109 | 0.40 | 0.32 | -0.08 | sell |
| Rock Springs Capital Management LP | 878,667 | 640,467 | -238,200 | 0.40 | 0.39 | -0.01 | sell |