| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 9,082,000 | 9,506,701 | +424,701 | 0.01 | 0.01 | +0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 5,037,854 | 5,037,854 | 0 | 10.76 | 12.31 | +1.55 | hold |
| NEA Management Company, LLC | 4,023,219 | 4,023,219 | 0 | 4.47 | 6.43 | +1.96 | hold |
| Enavate Sciences GP, LLC | 3,919,159 | 3,919,159 | 0 | 21.80 | 28.80 | +7.00 | hold |
| FEDERATED HERMES, INC. | 3,127,031 | 3,116,805 | -10,226 | 0.10 | 0.11 | +0.01 | sell |
| BlackRock, Inc. | 2,037,548 | 2,686,225 | +648,677 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Investors | 2,434,000 | 2,502,912 | +68,912 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 2,548,444 | 2,412,772 | -135,672 | 0.22 | 0.17 | -0.04 | sell |
| Fairmount Funds Management LLC | 2,359,025 | 2,359,025 | 0 | 3.33 | 3.96 | +0.63 | hold |
| STATE STREET CORP | 1,470,923 | 2,055,100 | +584,177 | 0.00 | 0.00 | +0.00 | buy |
| NVP Associates, LLC | 1,838,482 | 1,838,482 | 0 | 20.40 | 14.22 | -6.18 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,246,053 | 1,593,819 | +347,766 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 388,347 | 1,231,159 | +842,812 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 357,266 | 1,226,928 | +869,662 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 897,321 | 1,103,388 | +206,067 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 655,785 | 882,654 | +226,869 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 275,056 | 815,150 | +540,094 | 0.00 | 0.02 | +0.01 | buy |
| EcoR1 Capital, LLC | 789,500 | 789,500 | 0 | 0.66 | 0.99 | +0.33 | hold |
| MILLENNIUM MANAGEMENT LLC | 476,818 | 660,470 | +183,652 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 590,525 | 590,539 | +14 | 0.04 | 0.05 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 667,070 | 576,717 | -90,353 | 0.03 | 0.03 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 658,909 | 573,318 | -85,591 | 0.34 | 0.61 | +0.26 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,135,935 | 509,789 | -626,146 | 2.62 | 1.44 | -1.18 | sell |
| Rock Springs Capital Management LP | 502,077 | 502,077 | 0 | 0.58 | 0.62 | +0.04 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 591,991 | 490,766 | -101,225 | 4.14 | 4.05 | -0.09 | sell |
| Vestal Point Capital, LP | 200,000 | 365,000 | +165,000 | 0.11 | 0.22 | +0.11 | buy |
| MARSHALL WACE, LLP | 501,928 | 323,442 | -178,486 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 250,000 | 314,049 | +64,049 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 302,085 | +302,085 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 224,402 | 302,085 | +77,683 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 194,640 | 281,140 | +86,500 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 381,461 | 271,163 | -110,298 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 214,334 | 230,834 | +16,500 | 0.72 | 0.84 | +0.12 | buy |
| iA Global Asset Management Inc. | 215,830 | 215,130 | -700 | 0.06 | 0.06 | +0.01 | sell |
| Walleye Capital LLC | 125,232 | 209,050 | +83,818 | 0.02 | 0.03 | +0.01 | buy |
| Sio Capital Management, LLC | 331,730 | 208,557 | -123,173 | 0.93 | 0.91 | -0.03 | sell |
| CITADEL ADVISORS LLC | 66,870 | 195,780 | +128,910 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 367,405 | 178,089 | -189,316 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 29,612 | 167,145 | +137,533 | 0.01 | 0.08 | +0.06 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,999 | 151,086 | +141,087 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 93,396 | 134,979 | +41,583 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 42,874 | 125,185 | +82,311 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 29,610 | 115,965 | +86,355 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 100,000 | 0 | 0.13 | 0.10 | -0.03 | hold |
| Birchview Capital, LP | 70,000 | 93,601 | +23,601 | 0.78 | 1.11 | +0.33 | buy |
| Verition Fund Management LLC | 0 | 72,988 | +72,988 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 60,864 | 70,477 | +9,613 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 36,797 | 68,232 | +31,435 | 0.03 | 0.06 | +0.03 | buy |
| CSM Advisors, LLC | 0 | 67,622 | +67,622 | 0.00 | 0.04 | +0.04 | buy |
| Nuveen, LLC | 67,770 | 66,638 | -1,132 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 43,694 | 63,675 | +19,981 | 0.00 | 0.01 | +0.00 | buy |
| Swiss National Bank | 31,600 | 53,200 | +21,600 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 80,730 | 52,443 | -28,287 | 0.93 | 0.82 | -0.11 | sell |
| Jump Financial, LLC | 60,001 | 51,022 | -8,979 | 0.02 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 9,888 | 49,521 | +39,633 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 48,465 | +48,465 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 19,311 | 40,034 | +20,723 | 0.01 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 40,000 | 40,000 | 0 | 0.04 | 0.04 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,523 | 37,790 | +22,267 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 48,169 | 37,509 | -10,660 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 107,016 | 37,149 | -69,867 | 0.15 | 0.08 | -0.07 | sell |
| RHUMBLINE ADVISERS | 26,813 | 34,245 | +7,432 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 33,280 | +33,280 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 50,971 | 31,100 | -19,871 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,819 | 29,471 | +13,652 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,266 | 28,881 | +9,615 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 0 | 28,184 | +28,184 | 0.00 | 0.19 | +0.19 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 20,814 | 26,922 | +6,108 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,885 | 25,995 | +17,110 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,109 | 24,445 | -664 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 10,432 | 20,023 | +9,591 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 113,479 | 18,954 | -94,525 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,526 | 18,848 | +5,322 | 0.02 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 21,416 | 18,838 | -2,578 | 0.02 | 0.01 | -0.00 | sell |
| ALLSTATE CORP | 18,223 | 18,241 | +18 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,386 | 17,423 | +3,037 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 17,332 | +17,332 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 12,909 | 17,041 | +4,132 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,717 | 16,525 | +9,808 | 0.04 | 0.10 | +0.06 | buy |
| Point72 Asset Management, L.P. | 0 | 16,136 | +16,136 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 0 | 15,050 | +15,050 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 14,674 | +14,674 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 12,980 | +12,980 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,721 | 12,740 | +10,019 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 12,658 | 11,723 | -935 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,200 | 10,300 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 9,053 | +9,053 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 12,952 | 9,028 | -3,924 | 0.21 | 0.19 | -0.03 | sell |
| HRT FINANCIAL LP | 25,749 | 8,879 | -16,870 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 0 | 8,874 | +8,874 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 21,126 | 8,581 | -12,545 | 0.00 | 0.00 | -0.00 | sell |
| State of New Jersey Common Pension Fund D | 0 | 8,571 | +8,571 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 8,442 | +8,442 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,363 | 8,418 | +2,055 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 8,032 | +8,032 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,777 | 7,563 | +786 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 3,400 | 6,100 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 4,767 | 4,739 | -28 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,800 | 2,824 | +24 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,924 | 2,586 | +662 | 0.00 | 0.00 | +0.00 | buy |