| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SR ONE CAPITAL MANAGEMENT, LP | 0 | 4,911,539 | +4,911,539 | 0.00 | 16.66 | +16.66 | buy |
| NEA Management Company, LLC | 0 | 2,613,948 | +2,613,948 | 0.00 | 2.41 | +2.41 | buy |
| FMR LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 0 | 1,892,806 | +1,892,806 | 0.00 | 2.60 | +2.60 | buy |
| NVP Associates, LLC | 0 | 1,838,482 | +1,838,482 | 0.00 | 17.66 | +17.66 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,562,942 | +1,562,942 | 0.00 | 0.40 | +0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,501,428 | +1,501,428 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 0 | 1,183,260 | +1,183,260 | 0.00 | 1.66 | +1.66 | buy |
| FEDERATED HERMES, INC. | 0 | 1,158,000 | +1,158,000 | 0.00 | 0.04 | +0.04 | buy |
| Novo Holdings A/S | 0 | 1,150,000 | +1,150,000 | 0.00 | 0.97 | +0.97 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,144,035 | +1,144,035 | 0.00 | 0.42 | +0.42 | buy |
| Rock Springs Capital Management LP | 0 | 878,667 | +878,667 | 0.00 | 0.48 | +0.48 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 650,695 | +650,695 | 0.00 | 6.54 | +6.54 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 486,854 | +486,854 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 300,000 | +300,000 | 0.00 | 0.07 | +0.07 | buy |
| Eversept Partners, LP | 0 | 190,531 | +190,531 | 0.00 | 0.25 | +0.25 | buy |
| VANGUARD GROUP INC | 0 | 150,000 | +150,000 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.27 | +0.27 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 132,400 | +132,400 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 117,381 | +117,381 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 111,605 | +111,605 | 0.00 | 1.69 | +1.69 | buy |
| CITADEL ADVISORS LLC | 0 | 94,322 | +94,322 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 75,100 | +75,100 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 75,000 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 57,600 | +57,600 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 37,500 | +37,500 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 32,299 | +32,299 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 31,054 | +31,054 | 0.00 | 0.06 | +0.06 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 27,880 | +27,880 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 26,129 | +26,129 | 0.00 | 0.03 | +0.03 | buy |
| M&T BANK CORP | 0 | 24,884 | +24,884 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 24,857 | +24,857 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 15,500 | +15,500 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 15,463 | +15,463 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 13,529 | +13,529 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Capula Management Ltd | 0 | 10,615 | +10,615 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 10,074 | +10,074 | 0.00 | 0.02 | +0.02 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 3,849 | +3,849 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 3,762 | +3,762 | 0.00 | 0.00 | +0.00 | buy |
| MRP Capital Investments, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |