| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 0 | 1,006,558 | +1,006,558 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 150,000 | 979,323 | +829,323 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,150,000 | 1,600,000 | +450,000 | 0.97 | 0.79 | -0.17 | buy |
| MORGAN STANLEY | 0 | 358,212 | +358,212 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 300,000 | 627,669 | +327,669 | 0.07 | 0.07 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 24,857 | 348,760 | +323,903 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 211,506 | +211,506 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 171,940 | +171,940 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 131,665 | +131,665 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 124,246 | +124,246 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 118,660 | +118,660 | 0.00 | 0.00 | +0.00 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 650,695 | 736,645 | +85,950 | 6.54 | 4.07 | -2.46 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 56,039 | +56,039 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 0 | 38,942 | +38,942 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 38,400 | +38,400 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 24,884 | 62,622 | +37,738 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 35,944 | +35,944 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 33,790 | +33,790 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 29,839 | +29,839 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 486,854 | 511,220 | +24,366 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 22,990 | +22,990 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 18,245 | +18,245 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 117,381 | 134,896 | +17,515 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 0 | 16,500 | +16,500 | 0.00 | 0.11 | +0.11 | buy |
| CITIGROUP INC | 0 | 12,104 | +12,104 | 0.00 | 0.00 | +0.00 | buy |
| STONERIDGE INVESTMENT PARTNERS LLC | 0 | 10,955 | +10,955 | 0.00 | 0.03 | +0.03 | buy |
| MetLife Investment Management, LLC | 0 | 10,225 | +10,225 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 8,596 | +8,596 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,500 | 23,939 | +8,439 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 7,982 | +7,982 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 7,640 | +7,640 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 13,000 | 17,045 | +4,045 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 0 | 2,800 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 3,849 | 6,417 | +2,568 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,608 | +1,608 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,519 | +1,519 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,144 | +1,144 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,117 | +1,117 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 524 | +524 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 226 | +226 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,562,942 | 1,562,942 | 0 | 0.40 | 0.24 | -0.15 | hold |
| FEDERATED HERMES, INC. | 1,158,000 | 1,158,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| NEA Management Company, LLC | 2,613,948 | 2,613,948 | 0 | 2.41 | 1.21 | -1.20 | hold |
| NVP Associates, LLC | 1,838,482 | 1,838,482 | 0 | 17.66 | 8.05 | -9.60 | hold |
| Rock Springs Capital Management LP | 878,667 | 878,667 | 0 | 0.48 | 0.27 | -0.21 | hold |
| Vivo Capital, LLC | 1,183,260 | 1,183,260 | 0 | 1.66 | 1.09 | -0.57 | hold |
| Fairmount Funds Management LLC | 1,892,806 | 1,892,806 | 0 | 2.60 | 1.54 | -1.06 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 4,911,539 | 4,911,539 | 0 | 16.66 | 9.81 | -6.85 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 111,605 | 111,605 | 0 | 1.69 | 0.80 | -0.89 | hold |
| MRP Capital Investments, LLC | 35 | 35 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aster Capital Management (DIFC) Ltd | 3,018 | 0 | -3,018 | 0.01 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 3,762 | 0 | -3,762 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 75,000 | 66,202 | -8,798 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,074 | 0 | -10,074 | 0.02 | 0.00 | -0.02 | sell |
| Capula Management Ltd | 10,615 | 0 | -10,615 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 94,322 | 82,624 | -11,698 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 13,529 | 0 | -13,529 | 0.04 | 0.00 | -0.04 | sell |
| HRT FINANCIAL LP | 15,463 | 0 | -15,463 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 190,531 | 172,103 | -18,428 | 0.25 | 0.15 | -0.10 | sell |
| Point72 (DIFC) Ltd | 26,129 | 0 | -26,129 | 0.03 | 0.00 | -0.03 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27,880 | 0 | -27,880 | 0.00 | 0.00 | -0.00 | sell |
| Maven Securities LTD | 31,054 | 0 | -31,054 | 0.06 | 0.00 | -0.06 | sell |
| Squarepoint Ops LLC | 32,299 | 0 | -32,299 | 0.00 | 0.00 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 37,500 | 0 | -37,500 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 57,600 | 0 | -57,600 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 75,100 | 0 | -75,100 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 132,400 | 42,174 | -90,226 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 150,000 | 0 | -150,000 | 0.27 | 0.00 | -0.27 | sell |
| FMR LLC | 2,000,000 | 1,781,715 | -218,285 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,501,428 | 1,135,289 | -366,139 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,144,035 | 744,035 | -400,000 | 0.42 | 0.17 | -0.25 | sell |