| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,820,370 | 7,704,255 | +2,883,885 | 0.01 | 0.01 | +0.01 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 4,911,539 | 5,037,854 | +126,315 | 15.77 | 25.90 | +10.13 | buy |
| Enavate Sciences GP, LLC | 3,761,359 | 3,919,159 | +157,800 | 25.49 | 28.08 | +2.59 | buy |
| NEA Management Company, LLC | 2,733,719 | 3,523,219 | +789,500 | 3.33 | 6.52 | +3.19 | buy |
| FEDERATED HERMES, INC. | 1,861,838 | 2,715,578 | +853,740 | 0.07 | 0.16 | +0.09 | buy |
| Fairmount Funds Management LLC | 1,892,806 | 2,209,025 | +316,219 | 3.78 | 6.11 | +2.32 | buy |
| NVP Associates, LLC | 1,838,482 | 1,838,482 | 0 | 24.58 | 26.16 | +1.58 | hold |
| BlackRock, Inc. | 1,228,641 | 1,767,518 | +538,877 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,162,758 | 1,453,065 | +290,307 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 2,000,000 | 1,450,000 | -550,000 | 2.86 | 4.09 | +1.23 | sell |
| Polar Capital Holdings Plc | 0 | 1,057,609 | +1,057,609 | 0.00 | 0.18 | +0.18 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 857,524 | 855,334 | -2,190 | 0.00 | 0.01 | +0.00 | sell |
| Vivo Capital, LLC | 1,183,260 | 853,495 | -329,765 | 2.11 | 2.00 | -0.11 | sell |
| EcoR1 Capital, LLC | 0 | 789,500 | +789,500 | 0.00 | 1.31 | +1.31 | buy |
| ArrowMark Colorado Holdings LLC | 824,668 | 751,161 | -73,507 | 0.34 | 0.60 | +0.26 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 779,045 | 591,991 | -187,054 | 10.00 | 8.31 | -1.69 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 470,035 | 588,393 | +118,358 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 580,677 | 502,077 | -78,600 | 0.75 | 0.94 | +0.18 | sell |
| STATE STREET CORP | 377,485 | 438,294 | +60,809 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 374,298 | 369,248 | -5,050 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 368,400 | +368,400 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 178,396 | 213,193 | +34,797 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 193,153 | +193,153 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 145,796 | 187,968 | +42,172 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 163,860 | +163,860 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 133,278 | 155,366 | +22,088 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 133,439 | +133,439 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 130,698 | +130,698 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 88,733 | 128,335 | +39,602 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 158,742 | 121,016 | -37,726 | 0.27 | 0.25 | -0.02 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 96,665 | 83,353 | -13,312 | 2.11 | 1.62 | -0.49 | sell |
| AQR CAPITAL MANAGEMENT LLC | 24,584 | 78,220 | +53,636 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 35,492 | 69,495 | +34,003 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 41,688 | 51,802 | +10,114 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 20,519 | 50,850 | +30,331 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 112,612 | 50,636 | -61,976 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 71,850 | 49,160 | -22,690 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 47,160 | +47,160 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 20,042 | 44,077 | +24,035 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 22,876 | 34,377 | +11,501 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 31,600 | +31,600 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 24,459 | +24,459 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 21,214 | 21,946 | +732 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 6,548 | 21,726 | +15,178 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 12,455 | 21,151 | +8,696 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 18,350 | 18,350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,145 | 15,701 | +14,556 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 15,541 | +15,541 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 20,382 | 15,100 | -5,282 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 14,725 | +14,725 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 14,447 | +14,447 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 13,678 | +13,678 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 13,314 | +13,314 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 1,354 | 13,027 | +11,673 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 12,227 | 12,781 | +554 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,882 | 12,273 | +391 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 12,183 | +12,183 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 10,221 | +10,221 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 10,187 | +10,187 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 10,100 | 10,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Schonfeld Strategic Advisors LLC | 0 | 9,127 | +9,127 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 8,956 | +8,956 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 8,863 | +8,863 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,461 | 8,780 | +1,319 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 8,400 | +8,400 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 7,900 | +7,900 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 7,676 | +7,676 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,146 | 7,138 | +3,992 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 7,100 | +7,100 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,554 | +6,554 | 0.00 | 0.06 | +0.06 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 6,256 | +6,256 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,200 | 6,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 6,173 | +6,173 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 5,843 | 5,824 | -19 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 0 | 5,820 | +5,820 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,499 | 4,499 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KLP KAPITALFORVALTNING AS | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 2,800 | 2,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,608 | +2,608 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 188 | 2,351 | +2,163 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,469 | 2,178 | +709 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,974 | +1,974 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,608 | 1,368 | -240 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 1,345 | 1,345 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 1,121 | 1,087 | -34 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 0 | 1,054 | +1,054 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 953 | 884 | -69 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,388 | 795 | -593 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 524 | 593 | +69 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 332 | 389 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 179 | +179 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 183 | 179 | -4 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 115 | 115 | 0 | 0.00 | 0.00 | +0.00 | hold |
| J.Safra Asset Management Corp | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 24 | 86 | +62 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 58 | 73 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 67 | 67 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 0 | 47 | +47 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 339 | 42 | -297 | 0.00 | 0.00 | -0.00 | sell |
| Larson Financial Group LLC | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |