| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Helikon Investments Ltd | 1,013,324 | 2,787,131 | +1,773,807 | 4.26 | 11.10 | +6.84 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,132,557 | +1,132,557 | 0.00 | 1.31 | +1.31 | buy |
| NORGES BANK | 0 | 1,100,000 | +1,100,000 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 544,338 | 1,438,352 | +894,014 | 0.04 | 0.11 | +0.07 | buy |
| Vestal Point Capital, LP | 1,500,000 | 2,349,443 | +849,443 | 4.67 | 7.32 | +2.65 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 381,282 | 1,053,896 | +672,614 | 0.05 | 0.12 | +0.07 | buy |
| Siren, L.L.C. | 0 | 576,000 | +576,000 | 0.00 | 1.56 | +1.56 | buy |
| GOLDMAN SACHS GROUP INC | 348,797 | 792,712 | +443,915 | 0.01 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 1,394,019 | 1,804,703 | +410,684 | 9.33 | 11.30 | +1.98 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 410,000 | +410,000 | 0.00 | 1.42 | +1.42 | buy |
| Boxer Capital Management, LLC | 200,000 | 605,000 | +405,000 | 2.92 | 6.07 | +3.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 213,689 | 603,840 | +390,151 | 0.05 | 0.15 | +0.10 | buy |
| Pictet Asset Management Holding SA | 103,545 | 492,068 | +388,523 | 0.01 | 0.06 | +0.05 | buy |
| Logos Global Management LP | 675,000 | 1,024,000 | +349,000 | 3.87 | 5.87 | +2.00 | buy |
| Octagon Capital Advisors LP | 677,000 | 993,000 | +316,000 | 8.34 | 12.15 | +3.80 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 307,250 | +307,250 | 0.00 | 3.90 | +3.90 | buy |
| Ikarian Capital, LLC | 57,635 | 328,635 | +271,000 | 0.89 | 7.10 | +6.21 | buy |
| Two Seas Capital LP | 0 | 244,590 | +244,590 | 0.00 | 1.24 | +1.24 | buy |
| BANK OF AMERICA CORP /DE/ | 735,729 | 971,439 | +235,710 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 107,268 | 336,347 | +229,079 | 0.92 | 2.73 | +1.81 | buy |
| HRT FINANCIAL LP | 45,371 | 270,612 | +225,241 | 0.01 | 0.07 | +0.05 | buy |
| GREAT POINT PARTNERS LLC | 0 | 204,314 | +204,314 | 0.00 | 6.41 | +6.41 | buy |
| Kite Lake Capital Management (UK) LLP | 100,000 | 300,600 | +200,600 | 11.23 | 14.20 | +2.97 | buy |
| Western Standard LLC | 0 | 200,000 | +200,000 | 0.00 | 9.03 | +9.03 | buy |
| Vivo Capital, LLC | 239,539 | 414,899 | +175,360 | 2.22 | 5.05 | +2.83 | buy |
| Focus Partners Wealth | 0 | 161,874 | +161,874 | 0.00 | 0.02 | +0.02 | buy |
| Holocene Advisors, LP | 258,657 | 418,657 | +160,000 | 0.07 | 0.13 | +0.06 | buy |
| Darwin Global Management, Ltd. | 3,468,657 | 3,621,583 | +152,926 | 9.34 | 9.26 | -0.08 | buy |
| BlackRock, Inc. | 427,335 | 574,061 | +146,726 | 0.00 | 0.00 | +0.00 | buy |
| APEIRON CAPITAL Ltd | 0 | 130,600 | +130,600 | 0.00 | 11.18 | +11.18 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 123,289 | +123,289 | 0.00 | 0.00 | +0.00 | buy |
| DG Capital Management, LLC | 0 | 122,267 | +122,267 | 0.00 | 5.64 | +5.64 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,000 | 122,000 | +120,000 | 0.00 | 0.10 | +0.09 | buy |
| Caligan Partners LP | 1,461,924 | 1,557,924 | +96,000 | 11.51 | 10.02 | -1.50 | buy |
| WELLS FARGO & COMPANY/MN | 2,896 | 98,077 | +95,181 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 431,241 | 522,025 | +90,784 | 0.08 | 0.10 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 472,961 | 563,367 | +90,406 | 1.21 | 1.40 | +0.19 | buy |
| TORONTO DOMINION BANK | 0 | 88,331 | +88,331 | 0.00 | 0.02 | +0.02 | buy |
| DIADEMA PARTNERS LP | 75,944 | 163,644 | +87,700 | 3.39 | 7.63 | +4.23 | buy |
| TUDOR INVESTMENT CORP ET AL | 101,611 | 187,335 | +85,724 | 0.06 | 0.10 | +0.04 | buy |
| Patient Square Capital LP | 121,245 | 206,500 | +85,255 | 2.40 | 4.26 | +1.87 | buy |
| Qube Research & Technologies Ltd | 0 | 81,216 | +81,216 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 465,700 | 546,522 | +80,822 | 1.13 | 1.38 | +0.25 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 105,000 | 185,000 | +80,000 | 3.44 | 4.06 | +0.62 | buy |
| Verition Fund Management LLC | 25,948 | 105,791 | +79,843 | 0.03 | 0.10 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 320,576 | 394,957 | +74,381 | 0.59 | 0.70 | +0.11 | buy |
| NWI MANAGEMENT LP | 0 | 72,000 | +72,000 | 0.00 | 0.61 | +0.61 | buy |
| Optiver Holding B.V. | 4,538 | 76,368 | +71,830 | 0.02 | 0.15 | +0.13 | buy |
| SummitTX Capital, L.P. | 0 | 65,216 | +65,216 | 0.00 | 0.23 | +0.23 | buy |
| Erste Asset Management GmbH | 50,000 | 110,000 | +60,000 | 0.05 | 0.08 | +0.04 | buy |
| Senator Investment Group LP | 0 | 55,000 | +55,000 | 0.00 | 0.27 | +0.27 | buy |
| Quinn Opportunity Partners LLC | 16,000 | 66,045 | +50,045 | 0.09 | 0.41 | +0.32 | buy |
| Ghisallo Capital Management LLC | 0 | 48,000 | +48,000 | 0.00 | 0.12 | +0.12 | buy |
| Exome Asset Management LLC | 0 | 46,878 | +46,878 | 0.00 | 3.85 | +3.85 | buy |
| AMERIPRISE FINANCIAL INC | 83,031 | 129,816 | +46,785 | 0.00 | 0.00 | +0.00 | buy |
| ROYCE & ASSOCIATES LP | 0 | 45,103 | +45,103 | 0.00 | 0.05 | +0.05 | buy |
| Diametric Capital, LP | 10,000 | 51,903 | +41,903 | 0.29 | 0.74 | +0.44 | buy |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 90,000 | +40,000 | 0.37 | 0.48 | +0.11 | buy |
| Longaeva Partners L.P. | 0 | 40,000 | +40,000 | 0.00 | 0.15 | +0.15 | buy |
| MAVERICK CAPITAL LTD | 0 | 40,000 | +40,000 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 50,550 | 90,357 | +39,807 | 0.00 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 202,022 | 241,530 | +39,508 | 1.31 | 1.31 | -0.00 | buy |
| ALPINE ASSOCIATES MANAGEMENT INC. | 0 | 38,500 | +38,500 | 0.00 | 0.32 | +0.32 | buy |
| Knoll Capital Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 2.60 | +2.60 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 27,712 | +27,712 | 0.00 | 0.03 | +0.03 | buy |
| Marex Group plc | 0 | 27,336 | +27,336 | 0.00 | 0.03 | +0.03 | buy |
| Atle Fund Management AB | 31,590 | 58,170 | +26,580 | 1.54 | 2.09 | +0.54 | buy |
| RTW INVESTMENTS, LP | 0 | 26,400 | +26,400 | 0.00 | 0.03 | +0.03 | buy |
| Quantinno Capital Management LP | 0 | 25,437 | +25,437 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 8,436 | 33,811 | +25,375 | 0.05 | 0.22 | +0.17 | buy |
| PSquared Asset Management AG | 16,200 | 41,200 | +25,000 | 0.63 | 1.80 | +1.17 | buy |
| First Turn Management, LLC | 465,869 | 489,889 | +24,020 | 5.80 | 6.98 | +1.19 | buy |
| Burkehill Global Management, LP | 0 | 24,000 | +24,000 | 0.00 | 0.12 | +0.12 | buy |
| Alyeska Investment Group, L.P. | 0 | 23,940 | +23,940 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 8,594 | 31,632 | +23,038 | 0.01 | 0.02 | +0.01 | buy |
| MONIMUS CAPITAL MANAGEMENT, LP | 0 | 21,644 | +21,644 | 0.00 | 0.73 | +0.73 | buy |
| Persistent Asset Partners Ltd | 22,838 | 44,256 | +21,418 | 0.99 | 1.86 | +0.87 | buy |
| Rosalind Advisors, Inc. | 0 | 20,869 | +20,869 | 0.00 | 1.04 | +1.04 | buy |
| Diversify Advisory Services, LLC | 0 | 20,817 | +20,817 | 0.00 | 0.04 | +0.04 | buy |
| Alberta Investment Management Corp | 45,000 | 65,000 | +20,000 | 0.03 | 0.05 | +0.02 | buy |
| Resolute Capital Asset Partners LLC | 0 | 17,500 | +17,500 | 0.00 | 1.00 | +1.00 | buy |
| Atom Investors LP | 0 | 17,379 | +17,379 | 0.00 | 0.21 | +0.21 | buy |
| Birchview Capital, LP | 0 | 17,000 | +17,000 | 0.00 | 1.06 | +1.06 | buy |
| PFM Health Sciences, LP | 26,664 | 43,264 | +16,600 | 0.31 | 0.50 | +0.19 | buy |
| SIH Partners, LLLP | 0 | 15,564 | +15,564 | 0.00 | 0.09 | +0.09 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 14,000 | +14,000 | 0.00 | 0.36 | +0.36 | buy |
| NAN FUNG TRINITY (HK) Ltd | 128,940 | 142,083 | +13,143 | 1.58 | 1.87 | +0.29 | buy |
| OMERS ADMINISTRATION Corp | 0 | 13,000 | +13,000 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 8,757 | 19,200 | +10,443 | 0.02 | 0.05 | +0.02 | buy |
| Greenland Capital Management LP | 5,000 | 15,000 | +10,000 | 0.11 | 0.38 | +0.27 | buy |
| Virtu Financial LLC | 9,551 | 19,155 | +9,604 | 0.04 | 0.08 | +0.04 | buy |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 0 | 9,165 | +9,165 | 0.00 | 0.42 | +0.42 | buy |
| Rangeley Capital, LLC | 4,000 | 13,000 | +9,000 | 0.48 | 1.61 | +1.13 | buy |
| CITIGROUP INC | 1,729 | 10,061 | +8,332 | 0.00 | 0.00 | +0.00 | buy |
| MARK ASSET MANAGEMENT LP | 0 | 6,452 | +6,452 | 0.00 | 0.09 | +0.09 | buy |
| Covestor Ltd | 891 | 6,774 | +5,883 | 0.07 | 0.52 | +0.45 | buy |
| Tower Research Capital LLC (TRC) | 670 | 6,172 | +5,502 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 0 | 5,424 | +5,424 | 0.00 | 0.01 | +0.01 | buy |
| Bellevue Group AG | 1,048 | 6,397 | +5,349 | 0.00 | 0.02 | +0.02 | buy |
| HARVEY CAPITAL MANAGEMENT INC | 4,300 | 9,280 | +4,980 | 0.11 | 0.25 | +0.15 | buy |