| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GREAT POINT PARTNERS LLC | 1,550,000 | 2,488,483 | +938,483 | 2.83 | 5.55 | +2.72 | buy |
| Saturn V Capital Management LP | 0 | 622,970 | +622,970 | 0.00 | 3.57 | +3.57 | buy |
| Rosalind Advisors, Inc. | 0 | 378,416 | +378,416 | 0.00 | 5.06 | +5.06 | buy |
| VR Adviser, LLC | 998,570 | 1,345,780 | +347,210 | 0.73 | 0.92 | +0.18 | buy |
| Walleye Capital LLC | 0 | 187,044 | +187,044 | 0.00 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 427,949 | 593,455 | +165,506 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,249,295 | 1,395,052 | +145,757 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 720,425 | 851,839 | +131,414 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 75,000 | +75,000 | 0.00 | 0.30 | +0.30 | buy |
| HighVista Strategies LLC | 0 | 57,762 | +57,762 | 0.00 | 0.29 | +0.29 | buy |
| Atika Capital Management LLC | 0 | 49,993 | +49,993 | 0.00 | 0.08 | +0.08 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 88,837 | 120,168 | +31,331 | 0.02 | 0.04 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 14,389 | +14,389 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 130,317 | 137,809 | +7,492 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 5,644 | +5,644 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 57,767 | 62,966 | +5,199 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 419,400 | 423,000 | +3,600 | 0.01 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 199 | +199 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 425,000 | 425,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| HighTower Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 1,010,034 | 1,010,034 | 0 | 1.08 | 1.42 | +0.33 | hold |
| Financial Management Professionals, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 2,130,000 | 2,130,000 | 0 | 1.09 | 1.34 | +0.25 | hold |
| Samsara BioCapital, LLC | 850,000 | 850,000 | 0 | 1.41 | 1.88 | +0.47 | hold |
| Commodore Capital LP | 1,895,003 | 1,895,003 | 0 | 1.77 | 1.81 | +0.04 | hold |
| TCG Crossover Management, LLC | 1,100,000 | 1,100,000 | 0 | 1.31 | 1.24 | -0.06 | hold |
| Deep Track Capital, LP | 4,297,438 | 4,297,438 | 0 | 1.61 | 1.77 | +0.16 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CAXTON CORP | 16,743 | 15,808 | -935 | 0.97 | 1.29 | +0.32 | sell |
| Cubist Systematic Strategies, LLC | 23,300 | 14,022 | -9,278 | 0.00 | 0.00 | -0.00 | sell |
| Sandia Investment Management LP | 20,000 | 10,371 | -9,629 | 0.15 | 0.15 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 24,500 | 0 | -24,500 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 34,700 | 0 | -34,700 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 46,902 | 0 | -46,902 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Middle East FZE | 51,002 | 0 | -51,002 | 0.04 | 0.00 | -0.04 | sell |
| Ghisallo Capital Management LLC | 60,000 | 0 | -60,000 | 0.07 | 0.00 | -0.07 | sell |
| Polar Asset Management Partners Inc. | 259,488 | 117,888 | -141,600 | 0.08 | 0.05 | -0.03 | sell |
| CITADEL ADVISORS LLC | 732,867 | 551,510 | -181,357 | 0.01 | 0.01 | -0.00 | sell |
| Blackstone Inc. | 2,368,722 | 2,117,610 | -251,112 | 0.12 | 0.13 | +0.01 | sell |