| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 0 | 1,230,000 | +1,230,000 | 0.00 | 1.05 | +1.05 | buy |
| ADAR1 Capital Management, LLC | 1,513,393 | 2,210,019 | +696,626 | 2.28 | 2.66 | +0.37 | buy |
| CITADEL ADVISORS LLC | 855,676 | 1,373,860 | +518,184 | 0.01 | 0.01 | +0.00 | buy |
| Caligan Partners LP | 752,167 | 1,269,119 | +516,952 | 1.39 | 1.66 | +0.26 | buy |
| Allostery Investments LP | 591,253 | 1,099,654 | +508,401 | 8.50 | 9.91 | +1.42 | buy |
| Ensign Peak Advisors, Inc | 0 | 455,684 | +455,684 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 424,181 | 710,516 | +286,335 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.20 | +0.20 | buy |
| CITIGROUP INC | 0 | 184,239 | +184,239 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 728,919 | 907,679 | +178,760 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 406,903 | 570,668 | +163,765 | 0.09 | 0.12 | +0.03 | buy |
| Woodline Partners LP | 48,136 | 201,924 | +153,788 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 74,841 | +74,841 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 931,179 | 987,414 | +56,235 | 0.01 | 0.01 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,436,047 | 1,482,994 | +46,947 | 0.74 | 0.77 | +0.03 | buy |
| Paloma Partners Management Co | 0 | 38,449 | +38,449 | 0.00 | 0.04 | +0.04 | buy |
| MORGAN STANLEY | 479,326 | 497,153 | +17,827 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 11,668 | 19,000 | +7,332 | 0.00 | 0.00 | +0.00 | buy |
| Hurley Capital, LLC | 0 | 3,015 | +3,015 | 0.00 | 0.01 | +0.01 | buy |
| Shay Capital LLC | 50,029 | 52,829 | +2,800 | 0.09 | 0.10 | +0.01 | buy |
| Covestor Ltd | 0 | 2,660 | +2,660 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 7,557 | 10,152 | +2,595 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 12,512 | 13,792 | +1,280 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,095 | 1,478 | +383 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 706 | 738 | +32 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 16,749 | 16,749 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 49,064 | 49,064 | 0 | 0.13 | 0.12 | -0.02 | hold |
| Financial Management Professionals, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 2,130,000 | 2,130,000 | 0 | 0.86 | 1.01 | +0.15 | hold |
| VR Adviser, LLC | 1,345,780 | 1,345,780 | 0 | 0.68 | 0.72 | +0.04 | hold |
| Soleus Capital Management, L.P. | 125,000 | 125,000 | 0 | 0.07 | 0.06 | -0.01 | hold |
| TCG Crossover Management, LLC | 6,056,596 | 6,056,596 | 0 | 4.33 | 5.16 | +0.83 | hold |
| Deep Track Capital, LP | 3,579,209 | 3,579,209 | 0 | 0.98 | 0.72 | -0.26 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 225,470 | 225,191 | -279 | 0.04 | 0.03 | -0.00 | sell |
| GAMMA Investing LLC | 3,976 | 3,013 | -963 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 4,950 | 0 | -4,950 | 0.04 | 0.00 | -0.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 19,244 | 11,446 | -7,798 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 1,648,523 | 1,638,111 | -10,412 | 5.69 | 5.57 | -0.12 | sell |
| UBS Group AG | 174,873 | 162,554 | -12,319 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 15,000 | 0 | -15,000 | 0.09 | 0.00 | -0.09 | sell |
| TWO SIGMA INVESTMENTS, LP | 19,736 | 0 | -19,736 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 91,300 | 29,418 | -61,882 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 285,120 | 210,901 | -74,219 | 0.47 | 0.28 | -0.19 | sell |
| Walleye Capital LLC | 302,642 | 220,845 | -81,797 | 0.02 | 0.02 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 1,466,062 | 1,371,050 | -95,012 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 653,071 | 552,926 | -100,145 | 1.87 | 1.74 | -0.13 | sell |
| Atika Capital Management LLC | 103,929 | 0 | -103,929 | 0.10 | 0.00 | -0.10 | sell |
| Springhill Fund Asset Management (HK) Co Ltd | 207,600 | 0 | -207,600 | 2.47 | 0.00 | -2.47 | sell |
| Samsara BioCapital, LLC | 850,000 | 425,000 | -425,000 | 0.85 | 0.47 | -0.38 | sell |
| Blackstone Inc. | 936,607 | 0 | -936,607 | 0.03 | 0.00 | -0.03 | sell |
| Commodore Capital LP | 1,284,110 | 0 | -1,284,110 | 0.69 | 0.00 | -0.69 | sell |