| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 7,111,596 | 6,481,085 | -630,511 | 31.74 | 20.65 | -11.09 | sell |
| UBS Group AG | 4,423,906 | 4,547,406 | +123,500 | 0.12 | 0.09 | -0.03 | buy |
| Darwin Global Management, Ltd. | 3,178,501 | 3,468,657 | +290,156 | 8.90 | 9.34 | +0.43 | buy |
| MORGAN STANLEY | 3,151,994 | 1,704,958 | -1,447,036 | 0.03 | 0.01 | -0.01 | sell |
| Vestal Point Capital, LP | 1,900,000 | 1,500,000 | -400,000 | 9.40 | 4.67 | -4.73 | sell |
| Caligan Partners LP | 1,451,924 | 1,461,924 | +10,000 | 17.92 | 11.51 | -6.41 | buy |
| ADAR1 Capital Management, LLC | 1,317,329 | 1,394,019 | +76,690 | 13.29 | 9.33 | -3.96 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,009,966 | 1,322,938 | +312,972 | 0.57 | 0.62 | +0.05 | buy |
| FMR LLC | 1,365,657 | 1,286,373 | -79,284 | 0.01 | 0.01 | -0.00 | sell |
| Helikon Investments Ltd | 0 | 1,013,324 | +1,013,324 | 0.00 | 4.26 | +4.26 | buy |
| Eversept Partners, LP | 657,834 | 934,423 | +276,589 | 4.97 | 6.86 | +1.88 | buy |
| JANUS HENDERSON GROUP PLC | 667,761 | 878,829 | +211,068 | 0.04 | 0.05 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 875,796 | 875,796 | 0 | 0.69 | 0.56 | -0.13 | hold |
| LORD, ABBETT & CO. LLC | 849,732 | 854,920 | +5,188 | 0.35 | 0.31 | -0.04 | buy |
| Paradigm Biocapital Advisors LP | 1,417,473 | 772,473 | -645,000 | 5.12 | 1.76 | -3.36 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 691,973 | 765,915 | +73,942 | 8.28 | 7.23 | -1.05 | buy |
| Cormorant Asset Management, LP | 1,350,000 | 760,000 | -590,000 | 10.32 | 4.27 | -6.05 | sell |
| BANK OF AMERICA CORP /DE/ | 522,289 | 735,729 | +213,440 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 651,644 | 691,670 | +40,026 | 0.01 | 0.01 | -0.00 | buy |
| Octagon Capital Advisors LP | 756,000 | 677,000 | -79,000 | 12.76 | 8.34 | -4.42 | sell |
| Logos Global Management LP | 400,000 | 675,000 | +275,000 | 3.59 | 3.87 | +0.28 | buy |
| Point72 Asset Management, L.P. | 2,409,154 | 637,736 | -1,771,418 | 0.51 | 0.12 | -0.39 | sell |
| JPMORGAN CHASE & CO | 455,923 | 635,066 | +179,143 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 518,347 | 631,838 | +113,491 | 0.12 | 0.13 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 741,060 | 605,992 | -135,068 | 0.07 | 0.05 | -0.02 | sell |
| Artia Global Partners LP | 600,747 | 600,747 | 0 | 13.02 | 15.08 | +2.07 | hold |
| CITADEL ADVISORS LLC | 563,747 | 544,338 | -19,409 | 0.05 | 0.04 | -0.01 | sell |
| Saturn V Capital Management LP | 649,179 | 542,696 | -106,483 | 16.07 | 10.94 | -5.12 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 507,881 | 472,961 | -34,920 | 1.76 | 1.21 | -0.54 | sell |
| First Turn Management, LLC | 381,233 | 465,869 | +84,636 | 5.87 | 5.80 | -0.08 | buy |
| ORBIMED ADVISORS LLC | 367,900 | 465,700 | +97,800 | 1.02 | 1.13 | +0.12 | buy |
| Aberdeen Group plc | 426,658 | 431,241 | +4,583 | 0.09 | 0.08 | -0.01 | buy |
| BlackRock, Inc. | 436,713 | 427,335 | -9,378 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 505,000 | 405,000 | -100,000 | 4.89 | 2.64 | -2.25 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | 400,539 | -149,461 | 0.11 | 0.07 | -0.04 | sell |
| FRANKLIN RESOURCES INC | 449,121 | 382,830 | -66,291 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 754,836 | 381,282 | -373,554 | 0.14 | 0.05 | -0.08 | sell |
| GOLDMAN SACHS GROUP INC | 263,533 | 348,797 | +85,264 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 458,343 | 328,884 | -129,459 | 1.13 | 0.72 | -0.41 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 327,911 | 320,576 | -7,335 | 0.69 | 0.59 | -0.10 | sell |
| STEMPOINT CAPITAL LP | 391,783 | 313,791 | -77,992 | 9.07 | 6.72 | -2.35 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 217,890 | 312,274 | +94,384 | 0.02 | 0.02 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 422,193 | 302,530 | -119,663 | 8.24 | 3.97 | -4.27 | sell |
| Holocene Advisors, LP | 258,657 | 258,657 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Vivo Capital, LLC | 359,305 | 239,539 | -119,766 | 3.13 | 2.22 | -0.91 | sell |
| Woodline Partners LP | 225,892 | 225,892 | 0 | 0.12 | 0.10 | -0.02 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 358,322 | 213,689 | -144,633 | 0.09 | 0.05 | -0.04 | sell |
| JENNISON ASSOCIATES LLC | 127,907 | 210,534 | +82,627 | 0.01 | 0.02 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 95,729 | 202,022 | +106,293 | 0.57 | 1.31 | +0.74 | buy |
| Boxer Capital Management, LLC | 125,000 | 200,000 | +75,000 | 3.69 | 2.92 | -0.77 | buy |
| Evergreen Quality Fund GP, Ltd. | 224,300 | 144,300 | -80,000 | 0.60 | 0.37 | -0.23 | sell |
| ExodusPoint Capital Management, LP | 215,273 | 140,262 | -75,011 | 0.32 | 0.16 | -0.17 | sell |
| Hudson Bay Capital Management LP | 208,219 | 139,379 | -68,840 | 0.16 | 0.09 | -0.07 | sell |
| Nantahala Capital Management, LLC | 153,235 | 137,237 | -15,998 | 1.23 | 0.95 | -0.28 | sell |
| Sio Capital Management, LLC | 43,124 | 135,800 | +92,676 | 0.96 | 2.18 | +1.22 | buy |
| NAN FUNG TRINITY (HK) Ltd | 113,365 | 128,940 | +15,575 | 1.21 | 1.58 | +0.37 | buy |
| APIS CAPITAL ADVISORS, LLC | 89,000 | 128,800 | +39,800 | 2.09 | 2.21 | +0.12 | buy |
| Invesco Ltd. | 125,403 | 126,420 | +1,017 | 0.00 | 0.00 | -0.00 | buy |
| Patient Square Capital LP | 130,000 | 121,245 | -8,755 | 3.75 | 2.40 | -1.36 | sell |
| HighVista Strategies LLC | 72,185 | 113,254 | +41,069 | 2.51 | 3.48 | +0.98 | buy |
| TimesSquare Capital Management, LLC | 129,384 | 109,183 | -20,201 | 0.26 | 0.21 | -0.06 | sell |
| FEDERATED HERMES, INC. | 108,200 | 108,200 | 0 | 0.02 | 0.02 | -0.00 | hold |
| MPM BioImpact LLC | 56,316 | 107,268 | +50,952 | 0.87 | 0.92 | +0.05 | buy |
| IMC-Chicago, LLC | 16,519 | 106,143 | +89,624 | 0.04 | 0.18 | +0.14 | buy |
| Prosight Management, LP | 17,000 | 105,000 | +88,000 | 0.47 | 1.92 | +1.44 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 48,000 | 105,000 | +57,000 | 2.15 | 3.44 | +1.29 | buy |
| Pictet Asset Management Holding SA | 124,449 | 103,545 | -20,904 | 0.02 | 0.01 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 28,536 | 101,611 | +73,075 | 0.02 | 0.06 | +0.04 | buy |
| Kite Lake Capital Management (UK) LLP | 0 | 100,000 | +100,000 | 0.00 | 11.23 | +11.23 | buy |
| SEI INVESTMENTS CO | 87,153 | 94,220 | +7,067 | 0.01 | 0.01 | -0.00 | buy |
| JANE STREET GROUP, LLC | 423,257 | 94,141 | -329,116 | 0.07 | 0.01 | -0.06 | sell |
| BARCLAYS PLC | 308,789 | 90,775 | -218,014 | 0.02 | 0.00 | -0.01 | sell |
| Nicholas Investment Partners, LP | 83,068 | 90,206 | +7,138 | 0.82 | 0.72 | -0.09 | buy |
| AMERIPRISE FINANCIAL INC | 67,665 | 83,031 | +15,366 | 0.00 | 0.00 | +0.00 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 79,350 | 81,496 | +2,146 | 0.40 | 0.36 | -0.04 | buy |
| Velan Capital Investment Management LP | 67,000 | 77,000 | +10,000 | 5.26 | 5.37 | +0.11 | buy |
| LMR Partners LLP | 94,552 | 76,552 | -18,000 | 0.12 | 0.08 | -0.04 | sell |
| DIADEMA PARTNERS LP | 75,644 | 75,944 | +300 | 6.08 | 3.39 | -2.68 | buy |
| LPL Financial LLC | 62,842 | 75,366 | +12,524 | 0.00 | 0.00 | -0.00 | buy |
| Voleon Capital Management LP | 105,386 | 73,726 | -31,660 | 0.31 | 0.18 | -0.13 | sell |
| TD ASSET MANAGEMENT INC | 63,902 | 65,548 | +1,646 | 0.01 | 0.01 | -0.00 | buy |
| Russell Investments Group, Ltd. | 64,473 | 65,267 | +794 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 45,668 | 59,209 | +13,541 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 205,985 | 57,635 | -148,350 | 3.77 | 0.89 | -2.88 | sell |
| Centiva Capital, LP | 0 | 57,150 | +57,150 | 0.00 | 0.30 | +0.30 | buy |
| Samsara BioCapital, LLC | 75,442 | 56,581 | -18,861 | 1.05 | 0.61 | -0.44 | sell |
| K2 PRINCIPAL FUND, L.P. | 22,500 | 53,741 | +31,241 | 0.31 | 0.63 | +0.32 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 49,933 | 51,312 | +1,379 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 17,600 | 50,550 | +32,950 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.37 | +0.37 | buy |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| BNP Paribas Asset Management Holding S.A. | 24,806 | 49,516 | +24,710 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 43,768 | 48,749 | +4,981 | 0.05 | 0.04 | -0.01 | buy |
| Catalio Capital Management, LP | 98,514 | 47,193 | -51,321 | 2.35 | 1.10 | -1.25 | sell |
| HRT FINANCIAL LP | 0 | 45,500 | +45,500 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 45,371 | +45,371 | 0.00 | 0.01 | +0.01 | buy |
| Alberta Investment Management Corp | 0 | 45,000 | +45,000 | 0.00 | 0.03 | +0.03 | buy |
| SYQUANT CAPITAL SAS | 0 | 42,500 | +42,500 | 0.00 | 0.74 | +0.74 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,017 | 40,362 | +37,345 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,532 | 38,595 | +3,063 | 0.00 | 0.00 | -0.00 | buy |