| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,009,966 | 1,322,938 | +312,972 | 0.57 | 0.62 | +0.05 | buy |
| Darwin Global Management, Ltd. | 3,178,501 | 3,468,657 | +290,156 | 8.90 | 9.34 | +0.43 | buy |
| Eversept Partners, LP | 657,834 | 934,423 | +276,589 | 4.97 | 6.86 | +1.88 | buy |
| Logos Global Management LP | 400,000 | 675,000 | +275,000 | 3.59 | 3.87 | +0.28 | buy |
| READYSTATE ASSET MANAGEMENT LP | 95,729 | 202,022 | +106,293 | 0.57 | 1.31 | +0.74 | buy |
| Sio Capital Management, LLC | 43,124 | 135,800 | +92,676 | 0.96 | 2.18 | +1.22 | buy |
| Prosight Management, LP | 17,000 | 105,000 | +88,000 | 0.47 | 1.92 | +1.44 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 48,000 | 105,000 | +57,000 | 2.15 | 3.44 | +1.29 | buy |
| MPM BioImpact LLC | 56,316 | 107,268 | +50,952 | 0.87 | 0.92 | +0.05 | buy |
| HighVista Strategies LLC | 72,185 | 113,254 | +41,069 | 2.51 | 3.48 | +0.98 | buy |
| APIS CAPITAL ADVISORS, LLC | 89,000 | 128,800 | +39,800 | 2.09 | 2.21 | +0.12 | buy |
| K2 PRINCIPAL FUND, L.P. | 22,500 | 53,741 | +31,241 | 0.31 | 0.63 | +0.32 | buy |
| PSquared Asset Management AG | 240 | 16,200 | +15,960 | 0.09 | 0.63 | +0.54 | buy |
| NAN FUNG TRINITY (HK) Ltd | 113,365 | 128,940 | +15,575 | 1.21 | 1.58 | +0.37 | buy |
| FIFTH LANE CAPITAL, LP | 3,450 | 15,858 | +12,408 | 0.55 | 2.14 | +1.60 | buy |
| Cinctive Capital Management LP | 9,689 | 20,055 | +10,366 | 0.08 | 0.15 | +0.07 | buy |
| Caligan Partners LP | 1,451,924 | 1,461,924 | +10,000 | 17.92 | 11.51 | -6.41 | buy |
| Velan Capital Investment Management LP | 67,000 | 77,000 | +10,000 | 5.26 | 5.37 | +0.11 | buy |
| J. Goldman & Co LP | 3,292 | 12,749 | +9,457 | 0.02 | 0.07 | +0.05 | buy |
| Nicholas Investment Partners, LP | 83,068 | 90,206 | +7,138 | 0.82 | 0.72 | -0.09 | buy |
| Dorsey Wright & Associates | 16,620 | 23,452 | +6,832 | 0.48 | 0.32 | -0.16 | buy |
| FORA Capital, LLC | 7,859 | 13,186 | +5,327 | 0.10 | 0.11 | +0.01 | buy |
| Aberdeen Group plc | 426,658 | 431,241 | +4,583 | 0.09 | 0.08 | -0.01 | buy |
| FNY Investment Advisers, LLC | 2,590 | 7,056 | +4,466 | 0.10 | 0.34 | +0.25 | buy |
| Cannon Global Investment Management, LLC | 2,182 | 6,000 | +3,818 | 0.78 | 1.62 | +0.84 | buy |
| NINE MASTS CAPITAL Ltd | 4,000 | 7,500 | +3,500 | 0.09 | 0.13 | +0.04 | buy |
| Burns Matteson Capital Management, LLC | 2,681 | 5,249 | +2,568 | 0.15 | 0.23 | +0.08 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 79,350 | 81,496 | +2,146 | 0.40 | 0.36 | -0.04 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 7,750 | 9,659 | +1,909 | 0.06 | 0.08 | +0.02 | buy |
| CenterBook Partners LP | 7,176 | 8,436 | +1,260 | 0.05 | 0.05 | +0.00 | buy |
| HARVEY CAPITAL MANAGEMENT INC | 3,300 | 4,300 | +1,000 | 0.09 | 0.11 | +0.01 | buy |
| AdvisorShares Investments LLC | 11,200 | 11,802 | +602 | 0.25 | 0.24 | -0.01 | buy |
| Avior Wealth Management, LLC | 2,796 | 3,240 | +444 | 0.01 | 0.01 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 30,054 | 30,353 | +299 | 0.27 | 0.21 | -0.06 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 2,739 | 3,027 | +288 | 0.06 | 0.05 | -0.01 | buy |
| Grove Bank & Trust | 70 | 76 | +6 | 0.00 | 0.00 | -0.00 | buy |
| HighMark Wealth Management LLC | 230 | 150 | -80 | 0.01 | 0.01 | -0.01 | sell |
| BANQUE PICTET & CIE SA | 15,348 | 15,040 | -308 | 0.02 | 0.02 | -0.00 | sell |
| Colonial River Investments, LLC | 4,373 | 4,041 | -332 | 0.21 | 0.16 | -0.05 | sell |
| Total Clarity Wealth Management, Inc. | 9,245 | 7,410 | -1,835 | 0.30 | 0.19 | -0.11 | sell |
| PFM Health Sciences, LP | 31,878 | 26,664 | -5,214 | 0.44 | 0.31 | -0.12 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 327,911 | 320,576 | -7,335 | 0.69 | 0.59 | -0.10 | sell |
| Patient Square Capital LP | 130,000 | 121,245 | -8,755 | 3.75 | 2.40 | -1.36 | sell |
| Greenland Capital Management LP | 16,750 | 5,000 | -11,750 | 0.33 | 0.11 | -0.22 | sell |
| Nantahala Capital Management, LLC | 153,235 | 137,237 | -15,998 | 1.23 | 0.95 | -0.28 | sell |
| Samsara BioCapital, LLC | 75,442 | 56,581 | -18,861 | 1.05 | 0.61 | -0.44 | sell |
| BAMCO INC /NY/ | 25,000 | 5,500 | -19,500 | 0.01 | 0.00 | -0.01 | sell |
| TimesSquare Capital Management, LLC | 129,384 | 109,183 | -20,201 | 0.26 | 0.21 | -0.06 | sell |
| Atika Capital Management LLC | 55,000 | 28,800 | -26,200 | 1.03 | 0.51 | -0.53 | sell |
| Voleon Capital Management LP | 105,386 | 73,726 | -31,660 | 0.31 | 0.18 | -0.13 | sell |
| Ally Bridge Group (NY) LLC | 70,000 | 33,712 | -36,288 | 14.98 | 3.73 | -11.26 | sell |
| Octagon Capital Advisors LP | 756,000 | 677,000 | -79,000 | 12.76 | 8.34 | -4.42 | sell |
| Affinity Asset Advisors, LLC | 505,000 | 405,000 | -100,000 | 4.89 | 2.64 | -2.25 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 422,193 | 302,530 | -119,663 | 8.24 | 3.97 | -4.27 | sell |
| Vivo Capital, LLC | 359,305 | 239,539 | -119,766 | 3.13 | 2.22 | -0.91 | sell |
| PERCEPTIVE ADVISORS LLC | 458,343 | 328,884 | -129,459 | 1.13 | 0.72 | -0.41 | sell |
| Ikarian Capital, LLC | 205,985 | 57,635 | -148,350 | 3.77 | 0.89 | -2.88 | sell |
| Cormorant Asset Management, LP | 1,350,000 | 760,000 | -590,000 | 10.32 | 4.27 | -6.05 | sell |
| TCG Crossover Management, LLC | 7,111,596 | 6,481,085 | -630,511 | 31.74 | 20.65 | -11.09 | sell |
| Paradigm Biocapital Advisors LP | 1,417,473 | 772,473 | -645,000 | 5.12 | 1.76 | -3.36 | sell |