| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 1,100,000 | 6,056,596 | +4,956,596 | 1.24 | 8.34 | +7.10 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 75,000 | 455,800 | +380,800 | 0.30 | 1.49 | +1.19 | buy |
| JANUS HENDERSON GROUP PLC | 851,839 | 1,175,514 | +323,675 | 0.01 | 0.01 | +0.00 | buy |
| Atika Capital Management LLC | 49,993 | 170,637 | +120,644 | 0.08 | 0.26 | +0.18 | buy |
| Aberdeen Group plc | 0 | 118,206 | +118,206 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 425,000 | 525,000 | +100,000 | 0.01 | 0.01 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 34,750 | +34,750 | 0.00 | 0.28 | +0.28 | buy |
| Woodline Partners LP | 0 | 31,284 | +31,284 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 15,000 | 27,000 | +12,000 | 0.06 | 0.07 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 120,168 | 132,031 | +11,863 | 0.04 | 0.04 | +0.00 | buy |
| Saturn V Capital Management LP | 622,970 | 627,760 | +4,790 | 3.57 | 3.14 | -0.44 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,644 | 7,144 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 423,000 | 423,600 | +600 | 0.02 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 199 | 594 | +395 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 14,389 | 14,389 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighTower Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Financial Management Professionals, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 2,130,000 | 2,130,000 | 0 | 1.34 | 1.64 | +0.30 | hold |
| VR Adviser, LLC | 1,345,780 | 1,345,780 | 0 | 0.92 | 1.13 | +0.22 | hold |
| Rosalind Advisors, Inc. | 378,416 | 378,416 | 0 | 5.06 | 3.96 | -1.10 | hold |
| Samsara BioCapital, LLC | 850,000 | 850,000 | 0 | 1.88 | 2.35 | +0.47 | hold |
| FRANKLIN RESOURCES INC | 1,395,052 | 1,395,052 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CAXTON CORP | 15,808 | 13,900 | -1,908 | 1.29 | 0.93 | -0.36 | sell |
| Sandia Investment Management LP | 10,371 | 7,500 | -2,871 | 0.15 | 0.12 | -0.02 | sell |
| Cubist Systematic Strategies, LLC | 14,022 | 6,027 | -7,995 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 57,762 | 49,509 | -8,253 | 0.29 | 0.24 | -0.06 | sell |
| Walleye Capital LLC | 187,044 | 176,610 | -10,434 | 0.03 | 0.02 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 2,488,483 | 2,472,188 | -16,295 | 5.55 | 6.26 | +0.71 | sell |
| Nantahala Capital Management, LLC | 1,010,034 | 985,634 | -24,400 | 1.42 | 1.31 | -0.11 | sell |
| MORGAN STANLEY | 593,455 | 563,553 | -29,902 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 137,809 | 77,602 | -60,207 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 62,966 | 0 | -62,966 | 0.02 | 0.00 | -0.02 | sell |
| Polar Asset Management Partners Inc. | 117,888 | 53,239 | -64,649 | 0.05 | 0.02 | -0.03 | sell |
| CITADEL ADVISORS LLC | 551,510 | 454,760 | -96,750 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 4,297,438 | 4,179,763 | -117,675 | 1.77 | 1.65 | -0.12 | sell |
| Blackstone Inc. | 2,117,610 | 1,862,037 | -255,573 | 0.13 | 0.11 | -0.02 | sell |
| Commodore Capital LP | 1,895,003 | 1,284,110 | -610,893 | 1.81 | 1.16 | -0.65 | sell |