| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 2,210,019 | 3,071,340 | +861,321 | 2.66 | 3.82 | +1.16 | buy |
| Caligan Partners LP | 1,269,119 | 1,674,400 | +405,281 | 1.66 | 2.49 | +0.83 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 570,668 | 870,438 | +299,770 | 0.12 | 0.20 | +0.08 | buy |
| MILLENNIUM MANAGEMENT LLC | 987,414 | 1,251,765 | +264,351 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asset Management, L.P. | 29,418 | 167,887 | +138,469 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,478 | 113,391 | +111,913 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 87,748 | +87,748 | 0.00 | 0.22 | +0.22 | buy |
| Saturn V Capital Management LP | 552,926 | 622,479 | +69,553 | 1.74 | 1.93 | +0.19 | buy |
| J. Goldman & Co LP | 0 | 67,500 | +67,500 | 0.00 | 0.02 | +0.02 | buy |
| Paloma Partners Management Co | 38,449 | 95,130 | +56,681 | 0.04 | 0.17 | +0.12 | buy |
| Octagon Capital Advisors LP | 1,230,000 | 1,267,000 | +37,000 | 1.05 | 2.13 | +1.08 | buy |
| NewEdge Advisors, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 19,367 | +19,367 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,194 | +18,194 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 225,191 | 241,188 | +15,997 | 0.03 | 0.04 | +0.01 | buy |
| UBS Group AG | 162,554 | 167,656 | +5,102 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 13,792 | 16,097 | +2,305 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 49,064 | 51,156 | +2,092 | 0.12 | 0.14 | +0.03 | buy |
| RHUMBLINE ADVISERS | 738 | 981 | +243 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 16,749 | 16,818 | +69 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 10 | 36 | +26 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 455,684 | 455,684 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Nantahala Capital Management, LLC | 1,482,994 | 1,482,994 | 0 | 0.77 | 0.80 | +0.04 | hold |
| Financial Management Professionals, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 2,130,000 | 2,130,000 | 0 | 1.01 | 1.21 | +0.21 | hold |
| VR Adviser, LLC | 1,345,780 | 1,345,780 | 0 | 0.72 | 0.77 | +0.06 | hold |
| Hurley Capital, LLC | 3,015 | 3,015 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Aberdeen Group plc | 710,516 | 710,516 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Soleus Capital Management, L.P. | 125,000 | 125,000 | 0 | 0.06 | 0.07 | +0.00 | hold |
| TCG Crossover Management, LLC | 6,056,596 | 6,056,596 | 0 | 5.16 | 5.29 | +0.13 | hold |
| FRANKLIN RESOURCES INC | 1,371,050 | 1,371,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 11,446 | 10,670 | -776 | 0.00 | 0.00 | +0.00 | sell |
| GAMMA Investing LLC | 3,013 | 645 | -2,368 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 2,660 | 0 | -2,660 | 0.01 | 0.00 | -0.01 | sell |
| Cubist Systematic Strategies, LLC | 10,152 | 0 | -10,152 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 184,239 | 170,733 | -13,506 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 201,924 | 183,800 | -18,124 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 19,000 | 0 | -19,000 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 497,153 | 475,280 | -21,873 | 0.00 | 0.00 | +0.00 | sell |
| Shay Capital LLC | 52,829 | 0 | -52,829 | 0.10 | 0.00 | -0.10 | sell |
| MARSHALL WACE, LLP | 74,841 | 0 | -74,841 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 3,579,209 | 3,480,144 | -99,065 | 0.72 | 0.86 | +0.13 | sell |
| Affinity Asset Advisors, LLC | 200,000 | 100,000 | -100,000 | 0.20 | 0.11 | -0.08 | sell |
| CITADEL ADVISORS LLC | 1,373,860 | 1,252,257 | -121,603 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 210,901 | 0 | -210,901 | 0.28 | 0.00 | -0.28 | sell |
| Walleye Capital LLC | 220,845 | 0 | -220,845 | 0.02 | 0.00 | -0.02 | sell |
| GREAT POINT PARTNERS LLC | 1,638,111 | 1,291,617 | -346,494 | 5.57 | 6.42 | +0.86 | sell |
| Samsara BioCapital, LLC | 425,000 | 0 | -425,000 | 0.47 | 0.00 | -0.47 | sell |
| JPMORGAN CHASE & CO | 907,679 | 0 | -907,679 | 0.00 | 0.00 | -0.00 | sell |
| Allostery Investments LP | 1,099,654 | 167,350 | -932,304 | 9.91 | 16.31 | +6.40 | sell |