| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 6,481,085 | 6,007,834 | -473,251 | 20.65 | 19.24 | -1.40 | sell |
| Darwin Global Management, Ltd. | 3,468,657 | 3,621,583 | +152,926 | 9.34 | 9.26 | -0.08 | buy |
| Helikon Investments Ltd | 1,013,324 | 2,787,131 | +1,773,807 | 4.26 | 11.10 | +6.84 | buy |
| Vestal Point Capital, LP | 1,500,000 | 2,349,443 | +849,443 | 4.67 | 7.32 | +2.65 | buy |
| UBS Group AG | 4,547,406 | 1,844,918 | -2,702,488 | 0.09 | 0.04 | -0.05 | sell |
| ADAR1 Capital Management, LLC | 1,394,019 | 1,804,703 | +410,684 | 9.33 | 11.30 | +1.98 | buy |
| Caligan Partners LP | 1,461,924 | 1,557,924 | +96,000 | 11.51 | 10.02 | -1.50 | buy |
| CITADEL ADVISORS LLC | 544,338 | 1,438,352 | +894,014 | 0.04 | 0.11 | +0.07 | buy |
| MORGAN STANLEY | 1,704,958 | 1,432,185 | -272,773 | 0.01 | 0.01 | -0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,322,938 | 1,309,825 | -13,113 | 0.62 | 0.57 | -0.05 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,132,557 | +1,132,557 | 0.00 | 1.31 | +1.31 | buy |
| NORGES BANK | 0 | 1,100,000 | +1,100,000 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 381,282 | 1,053,896 | +672,614 | 0.05 | 0.12 | +0.07 | buy |
| Logos Global Management LP | 675,000 | 1,024,000 | +349,000 | 3.87 | 5.87 | +2.00 | buy |
| Octagon Capital Advisors LP | 677,000 | 993,000 | +316,000 | 8.34 | 12.15 | +3.80 | buy |
| BANK OF AMERICA CORP /DE/ | 735,729 | 971,439 | +235,710 | 0.01 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 934,423 | 913,880 | -20,543 | 6.86 | 6.64 | -0.22 | sell |
| GOLDMAN SACHS GROUP INC | 348,797 | 792,712 | +443,915 | 0.01 | 0.01 | +0.01 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 765,915 | 765,332 | -583 | 7.23 | 5.59 | -1.65 | sell |
| Cormorant Asset Management, LP | 760,000 | 675,000 | -85,000 | 4.27 | 4.61 | +0.34 | sell |
| Boxer Capital Management, LLC | 200,000 | 605,000 | +405,000 | 2.92 | 6.07 | +3.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 213,689 | 603,840 | +390,151 | 0.05 | 0.15 | +0.10 | buy |
| Siren, L.L.C. | 0 | 576,000 | +576,000 | 0.00 | 1.56 | +1.56 | buy |
| BlackRock, Inc. | 427,335 | 574,061 | +146,726 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 472,961 | 563,367 | +90,406 | 1.21 | 1.40 | +0.19 | buy |
| ORBIMED ADVISORS LLC | 465,700 | 546,522 | +80,822 | 1.13 | 1.38 | +0.25 | buy |
| Aberdeen Group plc | 431,241 | 522,025 | +90,784 | 0.08 | 0.10 | +0.02 | buy |
| Saturn V Capital Management LP | 542,696 | 518,865 | -23,831 | 10.94 | 9.91 | -1.03 | sell |
| Artia Global Partners LP | 600,747 | 516,447 | -84,300 | 15.08 | 13.08 | -2.00 | sell |
| Ensign Peak Advisors, Inc | 631,838 | 504,471 | -127,367 | 0.13 | 0.11 | -0.02 | sell |
| Pictet Asset Management Holding SA | 103,545 | 492,068 | +388,523 | 0.01 | 0.06 | +0.05 | buy |
| First Turn Management, LLC | 465,869 | 489,889 | +24,020 | 5.80 | 6.98 | +1.19 | buy |
| Holocene Advisors, LP | 258,657 | 418,657 | +160,000 | 0.07 | 0.13 | +0.06 | buy |
| Vivo Capital, LLC | 239,539 | 414,899 | +175,360 | 2.22 | 5.05 | +2.83 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 410,000 | +410,000 | 0.00 | 1.42 | +1.42 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 320,576 | 394,957 | +74,381 | 0.59 | 0.70 | +0.11 | buy |
| MPM BioImpact LLC | 107,268 | 336,347 | +229,079 | 0.92 | 2.73 | +1.81 | buy |
| Affinity Asset Advisors, LLC | 405,000 | 330,000 | -75,000 | 2.64 | 2.15 | -0.49 | sell |
| Ikarian Capital, LLC | 57,635 | 328,635 | +271,000 | 0.89 | 7.10 | +6.21 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 307,250 | +307,250 | 0.00 | 3.90 | +3.90 | buy |
| Kite Lake Capital Management (UK) LLP | 100,000 | 300,600 | +200,600 | 11.23 | 14.20 | +2.97 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 691,670 | 300,365 | -391,305 | 0.01 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 382,830 | 299,754 | -83,076 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 313,791 | 283,657 | -30,134 | 6.72 | 6.54 | -0.18 | sell |
| HRT FINANCIAL LP | 45,371 | 270,612 | +225,241 | 0.01 | 0.07 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 312,274 | 257,678 | -54,596 | 0.02 | 0.02 | -0.00 | sell |
| Two Seas Capital LP | 0 | 244,590 | +244,590 | 0.00 | 1.24 | +1.24 | buy |
| READYSTATE ASSET MANAGEMENT LP | 202,022 | 241,530 | +39,508 | 1.31 | 1.31 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 605,992 | 233,740 | -372,252 | 0.05 | 0.02 | -0.03 | sell |
| Woodline Partners LP | 225,892 | 226,966 | +1,074 | 0.10 | 0.09 | -0.00 | buy |
| Patient Square Capital LP | 121,245 | 206,500 | +85,255 | 2.40 | 4.26 | +1.87 | buy |
| GREAT POINT PARTNERS LLC | 0 | 204,314 | +204,314 | 0.00 | 6.41 | +6.41 | buy |
| Western Standard LLC | 0 | 200,000 | +200,000 | 0.00 | 9.03 | +9.03 | buy |
| JENNISON ASSOCIATES LLC | 210,534 | 196,524 | -14,010 | 0.02 | 0.02 | -0.00 | sell |
| FMR LLC | 1,286,373 | 191,689 | -1,094,684 | 0.01 | 0.00 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 101,611 | 187,335 | +85,724 | 0.06 | 0.10 | +0.04 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 105,000 | 185,000 | +80,000 | 3.44 | 4.06 | +0.62 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 302,530 | 169,593 | -132,937 | 3.97 | 2.52 | -1.45 | sell |
| DIADEMA PARTNERS LP | 75,944 | 163,644 | +87,700 | 3.39 | 7.63 | +4.23 | buy |
| Focus Partners Wealth | 0 | 161,874 | +161,874 | 0.00 | 0.02 | +0.02 | buy |
| NAN FUNG TRINITY (HK) Ltd | 128,940 | 142,083 | +13,143 | 1.58 | 1.87 | +0.29 | buy |
| Nantahala Capital Management, LLC | 137,237 | 133,759 | -3,478 | 0.95 | 1.08 | +0.12 | sell |
| APEIRON CAPITAL Ltd | 0 | 130,600 | +130,600 | 0.00 | 11.18 | +11.18 | buy |
| AMERIPRISE FINANCIAL INC | 83,031 | 129,816 | +46,785 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 123,289 | +123,289 | 0.00 | 0.00 | +0.00 | buy |
| DG Capital Management, LLC | 0 | 122,267 | +122,267 | 0.00 | 5.64 | +5.64 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,000 | 122,000 | +120,000 | 0.00 | 0.10 | +0.09 | buy |
| HighVista Strategies LLC | 113,254 | 113,031 | -223 | 3.48 | 3.43 | -0.05 | sell |
| Erste Asset Management GmbH | 50,000 | 110,000 | +60,000 | 0.05 | 0.08 | +0.04 | buy |
| Prosight Management, LP | 105,000 | 107,394 | +2,394 | 1.92 | 2.47 | +0.55 | buy |
| Verition Fund Management LLC | 25,948 | 105,791 | +79,843 | 0.03 | 0.10 | +0.07 | buy |
| TimesSquare Capital Management, LLC | 109,183 | 101,092 | -8,091 | 0.21 | 0.20 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 2,896 | 98,077 | +95,181 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 94,220 | 92,176 | -2,044 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 50,550 | 90,357 | +39,807 | 0.00 | 0.01 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 90,000 | +40,000 | 0.37 | 0.48 | +0.11 | buy |
| TORONTO DOMINION BANK | 0 | 88,331 | +88,331 | 0.00 | 0.02 | +0.02 | buy |
| IMC-Chicago, LLC | 106,143 | 87,392 | -18,751 | 0.18 | 0.11 | -0.07 | sell |
| ODDO BHF ASSET MANAGEMENT SAS | 81,496 | 81,496 | 0 | 0.36 | 0.50 | +0.14 | hold |
| Qube Research & Technologies Ltd | 0 | 81,216 | +81,216 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 75,366 | 78,999 | +3,633 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 108,200 | 77,900 | -30,300 | 0.02 | 0.01 | -0.00 | sell |
| Optiver Holding B.V. | 4,538 | 76,368 | +71,830 | 0.02 | 0.15 | +0.13 | buy |
| PERCEPTIVE ADVISORS LLC | 328,884 | 74,000 | -254,884 | 0.72 | 0.15 | -0.57 | sell |
| APIS CAPITAL ADVISORS, LLC | 128,800 | 74,000 | -54,800 | 2.21 | 0.96 | -1.25 | sell |
| NWI MANAGEMENT LP | 0 | 72,000 | +72,000 | 0.00 | 0.61 | +0.61 | buy |
| Quinn Opportunity Partners LLC | 16,000 | 66,045 | +50,045 | 0.09 | 0.41 | +0.32 | buy |
| Velan Capital Investment Management LP | 77,000 | 65,630 | -11,370 | 5.37 | 5.36 | -0.01 | sell |
| SummitTX Capital, L.P. | 0 | 65,216 | +65,216 | 0.00 | 0.23 | +0.23 | buy |
| Alberta Investment Management Corp | 45,000 | 65,000 | +20,000 | 0.03 | 0.05 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 59,209 | 63,354 | +4,145 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 94,141 | 60,195 | -33,946 | 0.01 | 0.01 | -0.01 | sell |
| Atle Fund Management AB | 31,590 | 58,170 | +26,580 | 1.54 | 2.09 | +0.54 | buy |
| Samsara BioCapital, LLC | 56,581 | 55,095 | -1,486 | 0.61 | 0.60 | -0.01 | sell |
| Senator Investment Group LP | 0 | 55,000 | +55,000 | 0.00 | 0.27 | +0.27 | buy |
| Diametric Capital, LP | 10,000 | 51,903 | +41,903 | 0.29 | 0.74 | +0.44 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 51,312 | 51,868 | +556 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 48,000 | +48,000 | 0.00 | 0.12 | +0.12 | buy |
| BNP Paribas Asset Management Holding S.A. | 49,516 | 47,460 | -2,056 | 0.01 | 0.01 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 46,878 | +46,878 | 0.00 | 3.85 | +3.85 | buy |