| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 77,602 | 645,637 | +568,035 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 27,000 | 521,612 | +494,612 | 0.07 | 1.01 | +0.94 | buy |
| Aberdeen Group plc | 118,206 | 316,431 | +198,225 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 125,000 | +125,000 | 0.00 | 0.12 | +0.12 | buy |
| Point72 Asset Management, L.P. | 423,600 | 542,900 | +119,300 | 0.02 | 0.02 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 132,031 | 223,814 | +91,783 | 0.04 | 0.06 | +0.02 | buy |
| Walleye Capital LLC | 176,610 | 257,417 | +80,807 | 0.02 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 31,284 | 81,730 | +50,446 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 30,910 | +30,910 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 627,760 | 648,019 | +20,259 | 3.14 | 2.67 | -0.47 | buy |
| CITADEL ADVISORS LLC | 454,760 | 466,429 | +11,669 | 0.01 | 0.01 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 6,027 | 16,453 | +10,426 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,144 | 13,044 | +5,900 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 525,000 | 530,861 | +5,861 | 0.01 | 0.01 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 455,800 | 461,660 | +5,860 | 1.49 | 1.20 | -0.29 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 14,389 | 15,572 | +1,183 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 594 | 684 | +90 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nantahala Capital Management, LLC | 985,634 | 985,634 | 0 | 1.31 | 0.96 | -0.35 | hold |
| Financial Management Professionals, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 2,130,000 | 2,130,000 | 0 | 1.64 | 1.30 | -0.34 | hold |
| VR Adviser, LLC | 1,345,780 | 1,345,780 | 0 | 1.13 | 0.81 | -0.32 | hold |
| Samsara BioCapital, LLC | 850,000 | 850,000 | 0 | 2.35 | 1.88 | -0.47 | hold |
| Commodore Capital LP | 1,284,110 | 1,284,110 | 0 | 1.16 | 0.92 | -0.23 | hold |
| TCG Crossover Management, LLC | 6,056,596 | 6,056,596 | 0 | 8.34 | 5.91 | -2.43 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HighVista Strategies LLC | 49,509 | 49,064 | -445 | 0.24 | 0.19 | -0.04 | sell |
| CAXTON CORP | 13,900 | 11,365 | -2,535 | 0.93 | 0.54 | -0.39 | sell |
| Sandia Investment Management LP | 7,500 | 0 | -7,500 | 0.12 | 0.00 | -0.12 | sell |
| Polar Asset Management Partners Inc. | 53,239 | 34,939 | -18,300 | 0.02 | 0.01 | -0.01 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 34,750 | 0 | -34,750 | 0.28 | 0.00 | -0.28 | sell |
| Atika Capital Management LLC | 170,637 | 113,631 | -57,006 | 0.26 | 0.14 | -0.12 | sell |
| MORGAN STANLEY | 563,553 | 504,752 | -58,801 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 1,395,052 | 1,324,352 | -70,700 | 0.01 | 0.00 | -0.00 | sell |
| Rosalind Advisors, Inc. | 378,416 | 139,983 | -238,433 | 3.96 | 1.07 | -2.89 | sell |
| Blackstone Inc. | 1,862,037 | 1,522,434 | -339,603 | 0.11 | 0.08 | -0.03 | sell |
| GREAT POINT PARTNERS LLC | 2,472,188 | 2,128,773 | -343,415 | 6.26 | 7.40 | +1.14 | sell |
| Deep Track Capital, LP | 4,179,763 | 3,579,209 | -600,554 | 1.65 | 1.32 | -0.33 | sell |
| JANUS HENDERSON GROUP PLC | 1,175,514 | 410,710 | -764,804 | 0.01 | 0.00 | -0.01 | sell |