| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| UBS Group AG | 167,656 | 4,461,262 | +4,293,606 | 0.00 | 0.07 | +0.07 | buy |
| Darwin Global Management, Ltd. | 0 | 3,164,501 | +3,164,501 | 0.00 | 7.33 | +7.33 | buy |
| Point72 Asset Management, L.P. | 167,887 | 2,925,352 | +2,757,465 | 0.00 | 0.54 | +0.54 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,564,196 | +1,564,196 | 0.00 | 3.93 | +3.93 | buy |
| FMR LLC | 0 | 1,430,673 | +1,430,673 | 0.00 | 0.01 | +0.01 | buy |
| TCG Crossover Management, LLC | 6,056,596 | 7,111,596 | +1,055,000 | 5.29 | 29.70 | +24.41 | buy |
| Vestal Point Capital, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 3.85 | +3.85 | buy |
| MORGAN STANLEY | 475,280 | 1,470,717 | +995,437 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 977,629 | +977,629 | 0.00 | 0.13 | +0.13 | buy |
| BAKER BROS. ADVISORS LP | 0 | 875,796 | +875,796 | 0.00 | 0.54 | +0.54 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 805,000 | +805,000 | 0.00 | 0.39 | +0.39 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 731,523 | +731,523 | 0.00 | 4.80 | +4.80 | buy |
| Fairmount Funds Management LLC | 0 | 713,434 | +713,434 | 0.00 | 5.45 | +5.45 | buy |
| BVF INC/IL | 0 | 558,031 | +558,031 | 0.00 | 1.92 | +1.92 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 539,704 | +539,704 | 0.00 | 6.63 | +6.63 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 479,869 | +479,869 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 461,301 | +461,301 | 0.00 | 0.09 | +0.09 | buy |
| Jefferies Financial Group Inc. | 0 | 457,325 | +457,325 | 0.00 | 0.36 | +0.36 | buy |
| Eversept Partners, LP | 0 | 426,499 | +426,499 | 0.00 | 2.77 | +2.77 | buy |
| Logos Global Management LP | 0 | 415,000 | +415,000 | 0.00 | 3.48 | +3.48 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 396,904 | +396,904 | 0.00 | 0.55 | +0.55 | buy |
| Ikarian Capital, LLC | 0 | 396,098 | +396,098 | 0.00 | 6.76 | +6.76 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 388,608 | +388,608 | 0.00 | 0.95 | +0.95 | buy |
| ORBIMED ADVISORS LLC | 0 | 380,000 | +380,000 | 0.00 | 0.77 | +0.77 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 378,300 | +378,300 | 0.00 | 0.96 | +0.96 | buy |
| Vivo Capital, LLC | 0 | 359,305 | +359,305 | 0.00 | 2.45 | +2.45 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 354,734 | +354,734 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 350,000 | +350,000 | 0.00 | 0.37 | +0.37 | buy |
| LORD, ABBETT & CO. LLC | 0 | 336,706 | +336,706 | 0.00 | 0.09 | +0.09 | buy |
| First Turn Management, LLC | 0 | 291,820 | +291,820 | 0.00 | 3.72 | +3.72 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 288,600 | +288,600 | 0.00 | 0.54 | +0.54 | buy |
| Affinity Asset Advisors, LLC | 100,000 | 360,000 | +260,000 | 0.11 | 2.84 | +2.73 | buy |
| Artia Global Partners LP | 0 | 225,453 | +225,453 | 0.00 | 3.37 | +3.37 | buy |
| Pictet Asset Management Holding SA | 0 | 196,836 | +196,836 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 0 | 189,704 | +189,704 | 0.00 | 0.02 | +0.02 | buy |
| Saturn V Capital Management LP | 622,479 | 801,224 | +178,745 | 1.93 | 14.92 | +12.99 | buy |
| Catalio Capital Management, LP | 0 | 162,141 | +162,141 | 0.00 | 2.54 | +2.54 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 160,220 | +160,220 | 0.00 | 0.03 | +0.03 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 156,747 | +156,747 | 0.00 | 1.35 | +1.35 | buy |
| Patient Square Capital LP | 0 | 151,833 | +151,833 | 0.00 | 3.45 | +3.45 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 135,626 | +135,626 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 51,156 | 184,468 | +133,312 | 0.14 | 3.84 | +3.70 | buy |
| TimesSquare Capital Management, LLC | 0 | 128,023 | +128,023 | 0.00 | 0.16 | +0.16 | buy |
| Woodline Partners LP | 183,800 | 311,042 | +127,242 | 0.01 | 0.12 | +0.12 | buy |
| Boxer Capital Management, LLC | 0 | 120,000 | +120,000 | 0.00 | 3.25 | +3.25 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 105,400 | +105,400 | 0.00 | 1.98 | +1.98 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 101,365 | +101,365 | 0.00 | 0.86 | +0.86 | buy |
| FEDERATED HERMES, INC. | 0 | 99,500 | +99,500 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 0 | 95,955 | +95,955 | 0.00 | 0.77 | +0.77 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 95,593 | +95,593 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 91,062 | +91,062 | 0.00 | 0.05 | +0.05 | buy |
| STEMPOINT CAPITAL LP | 87,748 | 166,273 | +78,525 | 0.22 | 2.85 | +2.63 | buy |
| Aberdeen Group plc | 710,516 | 787,417 | +76,901 | 0.01 | 0.11 | +0.10 | buy |
| Samsara BioCapital, LLC | 0 | 75,442 | +75,442 | 0.00 | 0.84 | +0.84 | buy |
| LMR Partners LLP | 0 | 74,078 | +74,078 | 0.00 | 0.08 | +0.08 | buy |
| Atika Capital Management LLC | 0 | 69,000 | +69,000 | 0.00 | 0.50 | +0.50 | buy |
| JANE STREET GROUP, LLC | 0 | 67,802 | +67,802 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 66,725 | +66,725 | 0.00 | 0.01 | +0.01 | buy |
| Velan Capital Investment Management LP | 0 | 64,389 | +64,389 | 0.00 | 5.13 | +5.13 | buy |
| Melqart Asset Management (UK) Ltd | 0 | 64,157 | +64,157 | 0.00 | 0.73 | +0.73 | buy |
| Simplify Asset Management Inc. | 0 | 61,449 | +61,449 | 0.00 | 0.11 | +0.11 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 58,618 | +58,618 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,267,000 | 1,325,000 | +58,000 | 2.13 | 17.56 | +15.43 | buy |
| Verition Fund Management LLC | 0 | 56,618 | +56,618 | 0.00 | 0.03 | +0.03 | buy |
| Trexquant Investment LP | 0 | 56,420 | +56,420 | 0.00 | 0.05 | +0.05 | buy |
| Parkman Healthcare Partners LLC | 0 | 55,197 | +55,197 | 0.00 | 0.51 | +0.51 | buy |
| HRT FINANCIAL LP | 0 | 53,078 | +53,078 | 0.00 | 0.02 | +0.02 | buy |
| Erste Asset Management GmbH | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 0 | 46,486 | +46,486 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 41,894 | +41,894 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 41,620 | +41,620 | 0.00 | 2.45 | +2.45 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 0 | 40,000 | +40,000 | 0.00 | 1.55 | +1.55 | buy |
| Resolute Capital Asset Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 1.78 | +1.78 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 35,000 | +35,000 | 0.00 | 0.06 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 34,614 | +34,614 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 32,886 | +32,886 | 0.00 | 0.59 | +0.59 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 32,883 | +32,883 | 0.00 | 0.02 | +0.02 | buy |
| Quinn Opportunity Partners LLC | 0 | 31,000 | +31,000 | 0.00 | 0.19 | +0.19 | buy |
| Privium Fund Management B.V. | 0 | 30,412 | +30,412 | 0.00 | 0.46 | +0.46 | buy |
| TFG Asset Management GP Ltd | 0 | 30,000 | +30,000 | 0.00 | 0.37 | +0.37 | buy |
| LPL Financial LLC | 0 | 29,247 | +29,247 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 27,537 | +27,537 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 26,136 | +26,136 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 25,820 | +25,820 | 0.00 | 0.09 | +0.09 | buy |
| Greenland Capital Management LP | 0 | 25,039 | +25,039 | 0.00 | 0.31 | +0.31 | buy |
| Optiver Holding B.V. | 0 | 23,104 | +23,104 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 20,300 | +20,300 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 19,428 | +19,428 | 0.00 | 0.13 | +0.13 | buy |
| Virtu Financial LLC | 0 | 19,095 | +19,095 | 0.00 | 0.09 | +0.09 | buy |
| Voleon Capital Management LP | 0 | 16,757 | +16,757 | 0.00 | 0.03 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 16,608 | +16,608 | 0.00 | 0.00 | +0.00 | buy |
| BAMCO INC /NY/ | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 16,818 | 29,852 | +13,034 | 0.00 | 0.00 | +0.00 | buy |
| Progeny 3, Inc. | 0 | 12,240 | +12,240 | 0.00 | 0.05 | +0.05 | buy |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 0 | 11,962 | +11,962 | 0.00 | 0.06 | +0.06 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,515 | +11,515 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 11,099 | +11,099 | 0.00 | 0.01 | +0.01 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 10,000 | +10,000 | 0.00 | 0.34 | +0.34 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 9,824 | +9,824 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 9,604 | +9,604 | 0.00 | 0.59 | +0.59 | buy |