| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 6,056,596 | 6,056,596 | 0 | 5.91 | 4.33 | -1.58 | hold |
| Deep Track Capital, LP | 3,579,209 | 3,579,209 | 0 | 1.32 | 0.98 | -0.33 | hold |
| Cormorant Asset Management, LP | 2,130,000 | 2,130,000 | 0 | 1.30 | 0.86 | -0.44 | hold |
| GREAT POINT PARTNERS LLC | 2,128,773 | 1,648,523 | -480,250 | 7.40 | 5.69 | -1.71 | sell |
| ADAR1 Capital Management, LLC | 521,612 | 1,513,393 | +991,781 | 1.01 | 2.28 | +1.28 | buy |
| FRANKLIN RESOURCES INC | 1,324,352 | 1,466,062 | +141,710 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 985,634 | 1,436,047 | +450,413 | 0.96 | 0.74 | -0.22 | buy |
| VR Adviser, LLC | 1,345,780 | 1,345,780 | 0 | 0.81 | 0.68 | -0.14 | hold |
| Commodore Capital LP | 1,284,110 | 1,284,110 | 0 | 0.92 | 0.69 | -0.24 | hold |
| Blackstone Inc. | 1,522,434 | 936,607 | -585,827 | 0.08 | 0.03 | -0.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 645,637 | 931,179 | +285,542 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 466,429 | 855,676 | +389,247 | 0.01 | 0.01 | +0.00 | buy |
| Samsara BioCapital, LLC | 850,000 | 850,000 | 0 | 1.88 | 0.85 | -1.03 | hold |
| Caligan Partners LP | 0 | 752,167 | +752,167 | 0.00 | 1.39 | +1.39 | buy |
| JPMORGAN CHASE & CO | 0 | 728,919 | +728,919 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 648,019 | 653,071 | +5,052 | 2.67 | 1.87 | -0.80 | buy |
| MORGAN STANLEY | 504,752 | 479,326 | -25,426 | 0.00 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 316,431 | 424,181 | +107,750 | 0.01 | 0.01 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 406,903 | +406,903 | 0.00 | 0.09 | +0.09 | buy |
| Walleye Capital LLC | 257,417 | 302,642 | +45,225 | 0.03 | 0.02 | -0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 461,660 | 285,120 | -176,540 | 1.20 | 0.47 | -0.73 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 223,814 | 225,470 | +1,656 | 0.06 | 0.04 | -0.02 | buy |
| UBS Group AG | 0 | 174,873 | +174,873 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 125,000 | 125,000 | 0 | 0.12 | 0.07 | -0.05 | hold |
| Atika Capital Management LLC | 113,631 | 103,929 | -9,702 | 0.14 | 0.10 | -0.04 | sell |
| Point72 Asset Management, L.P. | 542,900 | 91,300 | -451,600 | 0.02 | 0.00 | -0.02 | sell |
| Shay Capital LLC | 0 | 50,029 | +50,029 | 0.00 | 0.09 | +0.09 | buy |
| HighVista Strategies LLC | 49,064 | 49,064 | 0 | 0.19 | 0.13 | -0.06 | hold |
| Woodline Partners LP | 81,730 | 48,136 | -33,594 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 19,736 | +19,736 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 13,044 | 19,244 | +6,200 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 15,572 | 16,749 | +1,177 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.09 | +0.09 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 12,512 | +12,512 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 11,668 | +11,668 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cubist Systematic Strategies, LLC | 16,453 | 7,557 | -8,896 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 0 | 3,976 | +3,976 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,095 | +1,095 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 684 | 706 | +22 | 0.00 | 0.00 | -0.00 | buy |
| Financial Management Professionals, Inc. | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 530,861 | 0 | -530,861 | 0.01 | 0.00 | -0.01 | sell |
| JANUS HENDERSON GROUP PLC | 410,710 | 0 | -410,710 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 30,910 | 0 | -30,910 | 0.00 | 0.00 | -0.00 | sell |
| Polar Asset Management Partners Inc. | 34,939 | 0 | -34,939 | 0.01 | 0.00 | -0.01 | sell |
| CAXTON CORP | 11,365 | 0 | -11,365 | 0.54 | 0.00 | -0.54 | sell |
| Rosalind Advisors, Inc. | 139,983 | 0 | -139,983 | 1.07 | 0.00 | -1.07 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |