| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,000,000 | 1,900,000 | +900,000 | 3.85 | 9.40 | +5.55 | buy |
| LORD, ABBETT & CO. LLC | 336,706 | 849,732 | +513,026 | 0.09 | 0.35 | +0.27 | buy |
| Artia Global Partners LP | 225,453 | 600,747 | +375,294 | 3.37 | 13.02 | +9.65 | buy |
| Eversept Partners, LP | 426,499 | 657,834 | +231,335 | 2.50 | 4.47 | +1.97 | buy |
| STEMPOINT CAPITAL LP | 166,273 | 391,783 | +225,510 | 2.85 | 9.07 | +6.22 | buy |
| Affinity Asset Advisors, LLC | 360,000 | 505,000 | +145,000 | 2.84 | 4.89 | +2.05 | buy |
| First Turn Management, LLC | 291,820 | 381,233 | +89,413 | 3.72 | 5.87 | +2.15 | buy |
| Voleon Capital Management LP | 16,757 | 105,386 | +88,629 | 0.03 | 0.31 | +0.27 | buy |
| PERCEPTIVE ADVISORS LLC | 388,608 | 458,343 | +69,735 | 0.95 | 1.10 | +0.15 | buy |
| Nicholas Investment Partners, LP | 19,428 | 83,068 | +63,640 | 0.13 | 0.82 | +0.69 | buy |
| DIADEMA PARTNERS LP | 41,620 | 75,644 | +34,024 | 2.45 | 6.08 | +3.63 | buy |
| SummitTX Capital, L.P. | 25,820 | 56,174 | +30,354 | 0.09 | 0.23 | +0.14 | buy |
| Resolute Capital Asset Partners LLC | 40,000 | 65,000 | +25,000 | 1.78 | 4.24 | +2.46 | buy |
| Persistent Asset Partners Ltd | 9,604 | 24,413 | +14,809 | 0.59 | 1.85 | +1.26 | buy |
| Darwin Global Management, Ltd. | 3,164,501 | 3,178,501 | +14,000 | 7.33 | 8.90 | +1.57 | buy |
| NAN FUNG TRINITY (HK) Ltd | 101,365 | 113,365 | +12,000 | 0.86 | 1.21 | +0.35 | buy |
| BAMCO INC /NY/ | 14,000 | 25,000 | +11,000 | 0.00 | 0.01 | +0.01 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 40,000 | 48,000 | +8,000 | 1.55 | 2.15 | +0.60 | buy |
| Boxer Capital Management, LLC | 120,000 | 125,000 | +5,000 | 3.25 | 3.69 | +0.44 | buy |
| Velan Capital Investment Management LP | 64,389 | 67,000 | +2,611 | 5.13 | 5.26 | +0.12 | buy |
| TimesSquare Capital Management, LLC | 128,023 | 129,384 | +1,361 | 100.00 | 0.26 | -99.74 | buy |
| GILDER GAGNON HOWE & CO LLC | 9,824 | 11,030 | +1,206 | 0.01 | 0.02 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 2,438 | 3,079 | +641 | 0.04 | 0.08 | +0.04 | buy |
| BANK OF HAWAII | 3,006 | 3,454 | +448 | 0.01 | 0.02 | +0.01 | buy |
| Colonial River Investments, LLC | 4,349 | 4,373 | +24 | 0.14 | 0.21 | +0.07 | buy |
| Grove Bank & Trust | 62 | 70 | +8 | 0.00 | 0.00 | +0.00 | buy |
| HighMark Wealth Management LLC | 280 | 230 | -50 | 0.01 | 0.01 | +0.00 | sell |
| FNY Investment Advisers, LLC | 3,250 | 2,590 | -660 | 0.09 | 0.10 | +0.01 | sell |
| Rangeley Capital, LLC | 6,000 | 4,000 | -2,000 | 0.44 | 0.45 | +0.01 | sell |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 11,962 | 7,750 | -4,212 | 0.06 | 0.06 | +0.00 | sell |
| First Light Asset Management, LLC | 95,955 | 88,674 | -7,281 | 0.77 | 0.91 | +0.15 | sell |
| Greenland Capital Management LP | 25,039 | 16,750 | -8,289 | 0.31 | 0.33 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 380,000 | 367,900 | -12,100 | 0.77 | 1.02 | +0.24 | sell |
| Atika Capital Management LLC | 69,000 | 55,000 | -14,000 | 0.47 | 0.78 | +0.31 | sell |
| Logos Global Management LP | 415,000 | 400,000 | -15,000 | 3.48 | 3.59 | +0.11 | sell |
| APIS CAPITAL ADVISORS, LLC | 105,400 | 89,000 | -16,400 | 1.98 | 2.09 | +0.11 | sell |
| Patient Square Capital LP | 151,833 | 130,000 | -21,833 | 3.45 | 3.75 | +0.30 | sell |
| Melqart Asset Management (UK) Ltd | 64,157 | 32,991 | -31,166 | 0.73 | 0.44 | -0.29 | sell |
| ADAR1 Capital Management, LLC | 1,350,826 | 1,317,329 | -33,497 | 11.36 | 13.29 | +1.93 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 731,523 | 691,973 | -39,550 | 4.80 | 8.28 | +3.48 | sell |
| Simplify Asset Management Inc. | 61,449 | 16,953 | -44,496 | 0.11 | 0.04 | -0.07 | sell |
| J. Goldman & Co LP | 51,893 | 3,292 | -48,601 | 0.11 | 0.01 | -0.10 | sell |
| BVF INC/IL | 558,031 | 508,031 | -50,000 | 1.92 | 2.31 | +0.39 | sell |
| Catalio Capital Management, LP | 162,141 | 98,514 | -63,627 | 2.54 | 2.35 | -0.20 | sell |
| Evergreen Quality Fund GP, Ltd. | 288,600 | 224,300 | -64,300 | 0.54 | 0.60 | +0.05 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 396,904 | 327,911 | -68,993 | 0.55 | 0.69 | +0.14 | sell |
| HighVista Strategies LLC | 184,468 | 72,185 | -112,283 | 3.84 | 2.51 | -1.33 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 539,704 | 422,193 | -117,511 | 6.63 | 8.24 | +1.60 | sell |
| Paradigm Biocapital Advisors LP | 1,564,196 | 1,417,473 | -146,723 | 3.93 | 5.12 | +1.19 | sell |
| Saturn V Capital Management LP | 801,224 | 649,179 | -152,045 | 14.92 | 16.07 | +1.15 | sell |
| Ikarian Capital, LLC | 396,098 | 205,985 | -190,113 | 6.76 | 3.77 | -2.99 | sell |
| Holocene Advisors, LP | 461,301 | 258,657 | -202,644 | 0.09 | 0.07 | -0.02 | sell |
| Aberdeen Group plc | 787,417 | 426,658 | -360,759 | 0.11 | 0.09 | -0.02 | sell |
| Nantahala Capital Management, LLC | 557,564 | 153,235 | -404,329 | 1.64 | 0.68 | -0.96 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 977,629 | 550,000 | -427,629 | 0.13 | 0.11 | -0.02 | sell |
| Octagon Capital Advisors LP | 1,325,000 | 756,000 | -569,000 | 17.56 | 12.76 | -4.80 | sell |
| Cormorant Asset Management, LP | 1,950,000 | 1,350,000 | -600,000 | 11.42 | 8.42 | -3.01 | sell |