| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 7,111,596 | 7,111,596 | 0 | 29.70 | 31.74 | +2.04 | hold |
| UBS Group AG | 4,461,262 | 4,423,906 | -37,356 | 0.07 | 0.12 | +0.04 | sell |
| Darwin Global Management, Ltd. | 3,164,501 | 3,178,501 | +14,000 | 7.33 | 8.90 | +1.57 | buy |
| MORGAN STANLEY | 1,470,717 | 3,151,994 | +1,681,277 | 0.01 | 0.03 | +0.02 | buy |
| Point72 Asset Management, L.P. | 2,925,352 | 2,409,154 | -516,198 | 0.54 | 0.51 | -0.03 | sell |
| Vestal Point Capital, LP | 1,000,000 | 1,900,000 | +900,000 | 3.85 | 9.40 | +5.55 | buy |
| Caligan Partners LP | 1,451,924 | 1,451,924 | 0 | 17.10 | 17.92 | +0.82 | hold |
| Paradigm Biocapital Advisors LP | 1,564,196 | 1,417,473 | -146,723 | 3.93 | 5.12 | +1.19 | sell |
| FMR LLC | 1,430,673 | 1,365,657 | -65,016 | 0.01 | 0.01 | +0.00 | sell |
| Cormorant Asset Management, LP | 1,950,000 | 1,350,000 | -600,000 | 11.42 | 10.32 | -1.10 | sell |
| ADAR1 Capital Management, LLC | 1,350,826 | 1,317,329 | -33,497 | 11.36 | 13.29 | +1.93 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 1,009,966 | +1,009,966 | 0.00 | 0.57 | +0.57 | buy |
| BAKER BROS. ADVISORS LP | 875,796 | 875,796 | 0 | 0.54 | 0.69 | +0.15 | hold |
| LORD, ABBETT & CO. LLC | 336,706 | 849,732 | +513,026 | 0.09 | 0.35 | +0.27 | buy |
| DEUTSCHE BANK AG\ | 0 | 764,899 | +764,899 | 0.00 | 0.03 | +0.03 | buy |
| Octagon Capital Advisors LP | 1,325,000 | 756,000 | -569,000 | 17.56 | 12.76 | -4.80 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,614 | 754,836 | +720,222 | 0.00 | 0.14 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,100,030 | 741,060 | -358,970 | 0.07 | 0.07 | -0.00 | sell |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 731,523 | 691,973 | -39,550 | 4.80 | 8.28 | +3.48 | sell |
| JANUS HENDERSON GROUP PLC | 354,734 | 667,761 | +313,027 | 0.01 | 0.04 | +0.03 | buy |
| Eversept Partners, LP | 426,499 | 657,834 | +231,335 | 2.77 | 4.97 | +2.20 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 479,869 | 651,644 | +171,775 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 801,224 | 649,179 | -152,045 | 14.92 | 16.07 | +1.15 | sell |
| Artia Global Partners LP | 225,453 | 600,747 | +375,294 | 3.37 | 13.02 | +9.65 | buy |
| CITADEL ADVISORS LLC | 681,785 | 563,747 | -118,038 | 0.05 | 0.05 | +0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 977,629 | 550,000 | -427,629 | 0.13 | 0.11 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 95,593 | 522,289 | +426,696 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 455,684 | 518,347 | +62,663 | 0.06 | 0.12 | +0.06 | buy |
| BVF INC/IL | 558,031 | 508,031 | -50,000 | 1.92 | 2.31 | +0.39 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 597,931 | 507,881 | -90,050 | 1.28 | 1.76 | +0.47 | sell |
| Affinity Asset Advisors, LLC | 360,000 | 505,000 | +145,000 | 2.84 | 4.89 | +2.05 | buy |
| PERCEPTIVE ADVISORS LLC | 388,608 | 458,343 | +69,735 | 0.95 | 1.13 | +0.18 | buy |
| Jefferies Financial Group Inc. | 457,325 | 457,325 | 0 | 0.36 | 0.51 | +0.15 | hold |
| JPMORGAN CHASE & CO | 0 | 455,923 | +455,923 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 516,090 | 449,121 | -66,969 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 0 | 436,713 | +436,713 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 787,417 | 426,658 | -360,759 | 0.11 | 0.09 | -0.02 | sell |
| JANE STREET GROUP, LLC | 67,802 | 423,257 | +355,455 | 0.01 | 0.07 | +0.06 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 539,704 | 422,193 | -117,511 | 6.63 | 8.24 | +1.60 | sell |
| Logos Global Management LP | 415,000 | 400,000 | -15,000 | 3.48 | 3.59 | +0.11 | sell |
| STEMPOINT CAPITAL LP | 166,273 | 391,783 | +225,510 | 2.85 | 9.07 | +6.22 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 805,000 | 387,000 | -418,000 | 0.39 | 0.27 | -0.11 | sell |
| First Turn Management, LLC | 291,820 | 381,233 | +89,413 | 3.72 | 5.87 | +2.15 | buy |
| Frazier Life Sciences Management, L.P. | 378,300 | 378,300 | 0 | 0.96 | 1.37 | +0.41 | hold |
| ORBIMED ADVISORS LLC | 380,000 | 367,900 | -12,100 | 0.77 | 1.02 | +0.24 | sell |
| Vivo Capital, LLC | 359,305 | 359,305 | 0 | 2.45 | 3.13 | +0.68 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 160,220 | 358,322 | +198,102 | 0.03 | 0.09 | +0.06 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 396,904 | 327,911 | -68,993 | 0.55 | 0.69 | +0.14 | sell |
| BARCLAYS PLC | 76,342 | 308,789 | +232,447 | 0.00 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 135,626 | 263,533 | +127,907 | 0.00 | 0.01 | +0.00 | buy |
| Holocene Advisors, LP | 461,301 | 258,657 | -202,644 | 0.09 | 0.07 | -0.02 | sell |
| Woodline Partners LP | 311,042 | 225,892 | -85,150 | 0.12 | 0.12 | -0.01 | sell |
| Evergreen Quality Fund GP, Ltd. | 288,600 | 224,300 | -64,300 | 0.54 | 0.60 | +0.05 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 217,890 | +217,890 | 0.00 | 0.02 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 215,273 | +215,273 | 0.00 | 0.32 | +0.32 | buy |
| Hudson Bay Capital Management LP | 91,062 | 208,219 | +117,157 | 0.05 | 0.16 | +0.11 | buy |
| Ikarian Capital, LLC | 396,098 | 205,985 | -190,113 | 6.76 | 3.77 | -2.99 | sell |
| Nantahala Capital Management, LLC | 557,564 | 153,235 | -404,329 | 2.92 | 1.23 | -1.69 | sell |
| Patient Square Capital LP | 151,833 | 130,000 | -21,833 | 3.45 | 3.75 | +0.30 | sell |
| TimesSquare Capital Management, LLC | 128,023 | 129,384 | +1,361 | 0.16 | 0.26 | +0.11 | buy |
| JENNISON ASSOCIATES LLC | 0 | 127,907 | +127,907 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 0 | 125,403 | +125,403 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 120,000 | 125,000 | +5,000 | 3.25 | 3.69 | +0.44 | buy |
| Pictet Asset Management Holding SA | 196,836 | 124,449 | -72,387 | 0.02 | 0.02 | +0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 101,365 | 113,365 | +12,000 | 0.86 | 1.21 | +0.35 | buy |
| FEDERATED HERMES, INC. | 99,500 | 108,200 | +8,700 | 0.01 | 0.02 | +0.01 | buy |
| Voleon Capital Management LP | 16,757 | 105,386 | +88,629 | 0.03 | 0.31 | +0.27 | buy |
| Catalio Capital Management, LP | 162,141 | 98,514 | -63,627 | 2.54 | 2.35 | -0.20 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 95,729 | +95,729 | 0.00 | 0.57 | +0.57 | buy |
| LMR Partners LLP | 74,078 | 94,552 | +20,474 | 0.08 | 0.12 | +0.04 | buy |
| APIS CAPITAL ADVISORS, LLC | 105,400 | 89,000 | -16,400 | 1.98 | 2.09 | +0.11 | sell |
| First Light Asset Management, LLC | 95,955 | 88,674 | -7,281 | 0.77 | 0.91 | +0.15 | sell |
| SEI INVESTMENTS CO | 66,725 | 87,153 | +20,428 | 0.01 | 0.01 | +0.01 | buy |
| SAMLYN CAPITAL, LLC | 0 | 84,286 | +84,286 | 0.00 | 0.18 | +0.18 | buy |
| Nicholas Investment Partners, LP | 19,428 | 83,068 | +63,640 | 0.13 | 0.82 | +0.69 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 0 | 79,350 | +79,350 | 0.00 | 0.40 | +0.40 | buy |
| DIADEMA PARTNERS LP | 41,620 | 75,644 | +34,024 | 2.45 | 6.08 | +3.63 | buy |
| Samsara BioCapital, LLC | 75,442 | 75,442 | 0 | 0.84 | 1.05 | +0.21 | hold |
| HighVista Strategies LLC | 184,468 | 72,185 | -112,283 | 3.84 | 2.51 | -1.33 | sell |
| Ally Bridge Group (NY) LLC | 0 | 70,000 | +70,000 | 0.00 | 14.98 | +14.98 | buy |
| AMERIPRISE FINANCIAL INC | 58,618 | 67,665 | +9,047 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 64,389 | 67,000 | +2,611 | 5.13 | 5.26 | +0.12 | buy |
| Resolute Capital Asset Partners LLC | 40,000 | 65,000 | +25,000 | 1.78 | 4.24 | +2.46 | buy |
| Russell Investments Group, Ltd. | 41,894 | 64,473 | +22,579 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 46,486 | 63,902 | +17,416 | 0.00 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 29,247 | 62,842 | +33,595 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 56,618 | 61,317 | +4,699 | 0.03 | 0.04 | +0.02 | buy |
| MARSHALL WACE, LLP | 189,704 | 59,758 | -129,946 | 0.02 | 0.01 | -0.01 | sell |
| MPM BioImpact LLC | 0 | 56,316 | +56,316 | 0.00 | 0.87 | +0.87 | buy |
| SummitTX Capital, L.P. | 25,820 | 56,174 | +30,354 | 0.09 | 0.23 | +0.14 | buy |
| Atika Capital Management LLC | 69,000 | 55,000 | -14,000 | 0.50 | 1.03 | +0.53 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 54,993 | +54,993 | 0.00 | 0.17 | +0.17 | buy |
| Erste Asset Management GmbH | 50,000 | 50,000 | 0 | 0.04 | 0.06 | +0.02 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 29,852 | 49,933 | +20,081 | 0.00 | 0.00 | +0.00 | buy |
| FINDELL CAPITAL MANAGEMENT LLC | 40,000 | 48,000 | +8,000 | 1.55 | 2.15 | +0.60 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 20,300 | 45,668 | +25,368 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 45,000 | +45,000 | 0.00 | 0.26 | +0.26 | buy |
| Trexquant Investment LP | 56,420 | 43,768 | -12,652 | 0.05 | 0.05 | +0.00 | sell |
| Sio Capital Management, LLC | 0 | 43,124 | +43,124 | 0.00 | 0.96 | +0.96 | buy |
| Brevan Howard Capital Management LP | 0 | 37,270 | +37,270 | 0.00 | 0.09 | +0.09 | buy |