| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 16.28 | 26.85 | +10.57 | hold |
| FMR LLC | 5,018,880 | 6,743,902 | +1,725,022 | 0.01 | 0.03 | +0.02 | buy |
| RTW INVESTMENTS, LP | 2,142,591 | 2,467,591 | +325,000 | 0.94 | 2.42 | +1.49 | buy |
| Deep Track Capital, LP | 2,323,456 | 2,323,456 | 0 | 2.27 | 4.44 | +2.16 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,591,478 | 2,269,897 | +678,419 | 0.01 | 0.03 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,329,064 | 2,063,763 | +734,699 | 0.45 | 1.37 | +0.92 | buy |
| PERCEPTIVE ADVISORS LLC | 1,827,901 | 2,060,395 | +232,494 | 1.14 | 2.41 | +1.27 | buy |
| Fairmount Funds Management LLC | 2,941,176 | 2,048,647 | -892,529 | 8.68 | 14.84 | +6.16 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,977,901 | 1,977,901 | 0 | 0.86 | 1.67 | +0.81 | hold |
| VANGUARD GROUP INC | 1,162,871 | 1,868,666 | +705,795 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 681,101 | 1,842,515 | +1,161,414 | 0.70 | 3.95 | +3.25 | buy |
| STATE STREET CORP | 379,270 | 1,347,797 | +968,527 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 770,681 | 1,170,327 | +399,646 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,089,780 | 1,035,380 | -54,400 | 0.01 | 0.02 | +0.01 | sell |
| Darwin Global Management, Ltd. | 0 | 832,198 | +832,198 | 0.00 | 7.36 | +7.36 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 441,472 | 761,024 | +319,552 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 10,640 | 745,118 | +734,478 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 1,277,901 | 718,901 | -559,000 | 0.72 | 0.88 | +0.16 | sell |
| Woodline Partners LP | 326,102 | 702,421 | +376,319 | 0.10 | 0.43 | +0.33 | buy |
| Affinity Asset Advisors, LLC | 537,093 | 592,093 | +55,000 | 2.99 | 6.40 | +3.40 | buy |
| Point72 Asset Management, L.P. | 708,400 | 487,200 | -221,200 | 0.06 | 0.09 | +0.03 | sell |
| GREAT POINT PARTNERS LLC | 400,000 | 400,000 | 0 | 1.90 | 4.14 | +2.24 | hold |
| BANK OF AMERICA CORP /DE/ | 489,209 | 396,778 | -92,431 | 0.00 | 0.00 | +0.00 | sell |
| Avidity Partners Management LP | 0 | 384,893 | +384,893 | 0.00 | 0.91 | +0.91 | buy |
| First Turn Management, LLC | 0 | 379,803 | +379,803 | 0.00 | 3.78 | +3.78 | buy |
| Paradigm Biocapital Advisors LP | 0 | 330,000 | +330,000 | 0.00 | 0.77 | +0.77 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 329,000 | +329,000 | 0.00 | 0.38 | +0.38 | buy |
| NORTHERN TRUST CORP | 176,773 | 324,224 | +147,451 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 305,000 | +305,000 | 0.00 | 0.12 | +0.12 | buy |
| JENNISON ASSOCIATES LLC | 103,744 | 302,892 | +199,148 | 0.00 | 0.01 | +0.01 | buy |
| Commodore Capital LP | 250,000 | 290,000 | +40,000 | 0.61 | 1.29 | +0.68 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 155,765 | 240,766 | +85,001 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 351,810 | 230,000 | -121,810 | 0.05 | 0.07 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 525,000 | 175,000 | -350,000 | 0.03 | 0.02 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 283,683 | 167,878 | -115,805 | 0.32 | 0.45 | +0.13 | sell |
| Artal Group S.A. | 0 | 152,500 | +152,500 | 0.00 | 0.26 | +0.26 | buy |
| TD ASSET MANAGEMENT INC | 100,846 | 148,206 | +47,360 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 65,683 | 137,267 | +71,584 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 67,699 | 136,138 | +68,439 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 119,403 | +119,403 | 0.00 | 2.83 | +2.83 | buy |
| MILLENNIUM MANAGEMENT LLC | 28,775 | 118,974 | +90,199 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 11,609 | 116,673 | +105,064 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 27,751 | 112,992 | +85,241 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 79,410 | 109,410 | +30,000 | 0.02 | 0.08 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.69 | +0.69 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,820 | 99,659 | +83,839 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 3,769 | 93,106 | +89,337 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 0 | 90,000 | +90,000 | 0.00 | 0.04 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 25,039 | 89,480 | +64,441 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 88,700 | +88,700 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,100 | 85,201 | +34,101 | 0.00 | 0.01 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 78,000 | +78,000 | 0.00 | 1.81 | +1.81 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 76,481 | +76,481 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 0 | 76,031 | +76,031 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 66,128 | +66,128 | 0.00 | 0.02 | +0.02 | buy |
| Artia Global Partners LP | 10,381 | 61,590 | +51,209 | 0.11 | 1.00 | +0.89 | buy |
| JANE STREET GROUP, LLC | 13,403 | 56,179 | +42,776 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 27,228 | 55,696 | +28,468 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 55,113 | +55,113 | 0.00 | 0.57 | +0.57 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.93 | +0.93 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 44,868 | +44,868 | 0.00 | 1.97 | +1.97 | buy |
| Swiss National Bank | 33,000 | 41,300 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 41,001 | +41,001 | 0.00 | 0.05 | +0.05 | buy |
| Integral Health Asset Management, LLC | 0 | 40,000 | +40,000 | 0.00 | 0.26 | +0.26 | buy |
| Nicholas Investment Partners, LP | 0 | 37,747 | +37,747 | 0.00 | 0.26 | +0.26 | buy |
| BARCLAYS PLC | 34,056 | 36,646 | +2,590 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 23,064 | 24,333 | +1,269 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 23,229 | +23,229 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,309 | 23,002 | +4,693 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,969 | 21,770 | +12,801 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,638 | 21,229 | +10,591 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 10,203 | 20,391 | +10,188 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 10,337 | 20,259 | +9,922 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 35,000 | 20,000 | -15,000 | 0.11 | 0.12 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 7,671 | 19,206 | +11,535 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 18,193 | +18,193 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,481 | 16,658 | +7,177 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 14,818 | +14,818 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 22,248 | 14,807 | -7,441 | 0.01 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 5,858 | 13,428 | +7,570 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 8,153 | 13,333 | +5,180 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 12,522 | +12,522 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 9,231 | 12,121 | +2,890 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 12,000 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 10,920 | +10,920 | 0.00 | 0.03 | +0.03 | buy |
| Scientech Research LLC | 0 | 10,121 | +10,121 | 0.00 | 0.36 | +0.36 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,786 | 10,086 | -3,700 | 0.00 | 0.00 | +0.00 | sell |
| ProShare Advisors LLC | 0 | 10,038 | +10,038 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,751 | +9,751 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 9,629 | +9,629 | 0.00 | 0.06 | +0.06 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 7,897 | +7,897 | 0.00 | 0.09 | +0.09 | buy |
| Global Endowment Management, LP | 0 | 7,797 | +7,797 | 0.00 | 0.05 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 5,555 | 7,155 | +1,600 | 0.03 | 0.06 | +0.03 | buy |
| Bayesian Capital Management, LP | 0 | 6,771 | +6,771 | 0.00 | 0.04 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 6,765 | +6,765 | 0.00 | 0.00 | +0.00 | buy |
| Family Management Corp | 0 | 6,740 | +6,740 | 0.00 | 0.08 | +0.08 | buy |
| COMERICA BANK | 106 | 6,576 | +6,470 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 6,474 | +6,474 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 479,686 | 6,110 | -473,576 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 0 | 6,000 | +6,000 | 0.00 | 0.11 | +0.11 | buy |