| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 681,101 | 1,842,515 | +1,161,414 | 0.70 | 3.95 | +3.25 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,329,064 | 2,063,763 | +734,699 | 0.45 | 1.37 | +0.92 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 770,681 | 1,170,327 | +399,646 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 326,102 | 702,421 | +376,319 | 0.10 | 0.43 | +0.33 | buy |
| RTW INVESTMENTS, LP | 2,142,591 | 2,467,591 | +325,000 | 0.94 | 2.42 | +1.49 | buy |
| PERCEPTIVE ADVISORS LLC | 1,827,901 | 2,060,395 | +232,494 | 1.14 | 2.40 | +1.26 | buy |
| JENNISON ASSOCIATES LLC | 103,744 | 302,892 | +199,148 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 537,093 | 592,093 | +55,000 | 2.99 | 6.40 | +3.40 | buy |
| Artia Global Partners LP | 10,381 | 61,590 | +51,209 | 0.11 | 1.00 | +0.89 | buy |
| TD ASSET MANAGEMENT INC | 100,846 | 148,206 | +47,360 | 0.00 | 0.01 | +0.01 | buy |
| Commodore Capital LP | 250,000 | 290,000 | +40,000 | 0.61 | 1.29 | +0.68 | buy |
| ArrowMark Colorado Holdings LLC | 79,410 | 109,410 | +30,000 | 0.02 | 0.08 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 5,555 | 7,155 | +1,600 | 0.03 | 0.06 | +0.03 | buy |
| VIRTUS ADVISERS, LLC | 3,984 | 3,727 | -257 | 0.07 | 0.13 | +0.06 | sell |
| Soleus Capital Management, L.P. | 35,000 | 20,000 | -15,000 | 0.11 | 0.12 | +0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 283,683 | 167,878 | -115,805 | 0.32 | 0.45 | +0.13 | sell |
| Blackstone Inc. | 351,810 | 230,000 | -121,810 | 0.04 | 0.06 | +0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 525,000 | 175,000 | -350,000 | 0.03 | 0.02 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 1,277,901 | 718,901 | -559,000 | 0.72 | 0.88 | +0.16 | sell |
| Fairmount Funds Management LLC | 2,941,176 | 2,048,647 | -892,529 | 8.68 | 14.84 | +6.16 | sell |