| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,135,100 | 1,793,833 | +658,733 | 0.03 | 0.04 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 240,200 | 727,000 | +486,800 | 0.02 | 0.05 | +0.03 | buy |
| Affinity Asset Advisors, LLC | 931,728 | 1,151,199 | +219,471 | 6.59 | 6.73 | +0.14 | buy |
| Blackstone Inc. | 80,000 | 183,747 | +103,747 | 0.02 | 0.03 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 200,000 | +100,000 | 0.30 | 0.41 | +0.11 | buy |
| PERCEPTIVE ADVISORS LLC | 1,047,232 | 1,122,767 | +75,535 | 1.31 | 1.48 | +0.17 | buy |
| ADAR1 Capital Management, LLC | 41,274 | 104,853 | +63,579 | 0.39 | 0.75 | +0.37 | buy |
| Woodline Partners LP | 1,015,608 | 1,061,053 | +45,445 | 0.31 | 0.26 | -0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 58,466 | 96,992 | +38,526 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 92,854 | 108,340 | +15,486 | 0.18 | 0.20 | +0.03 | buy |
| B Group, Inc. | 15,000 | 30,000 | +15,000 | 0.42 | 0.97 | +0.56 | buy |
| TWO SIGMA INVESTMENTS, LP | 266,482 | 252,135 | +14,347 | 0.03 | 0.02 | 0.00 | sell |
| Allostery Investments LP | 100,000 | 110,000 | +10,000 | 8.89 | 5.93 | -2.97 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 72,307 | 78,397 | +6,090 | 0.07 | 0.07 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 945 | 1,153 | +208 | 0.00 | 0.00 | +0.00 | buy |
| Family Management Corp | 7,013 | 6,860 | -153 | 0.05 | 0.04 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 9,547 | 9,032 | -515 | 0.04 | 0.03 | -0.01 | sell |
| PROFUND ADVISORS LLC | 11,436 | 9,215 | -2,221 | 0.02 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 36,410 | 33,096 | -3,314 | 0.01 | 0.01 | -0.00 | sell |
| Persistent Asset Partners Ltd | 17,940 | 9,178 | -8,762 | 0.64 | 0.30 | -0.33 | sell |
| DIADEMA PARTNERS LP | 50,620 | 40,000 | -10,620 | 2.58 | 1.19 | -1.39 | sell |
| Capital World Investors | 205,100 | 193,895 | -11,205 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 57,673 | 43,001 | -14,672 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 312,391 | 293,757 | -18,634 | 0.01 | 0.01 | -0.00 | sell |
| First Turn Management, LLC | 252,725 | 229,675 | -23,050 | 2.05 | 1.73 | -0.32 | sell |
| TD ASSET MANAGEMENT INC | 126,446 | 101,388 | -25,058 | 0.01 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 85,000 | 46,663 | -38,337 | 0.51 | 0.21 | -0.31 | sell |
| Soleus Capital Management, L.P. | 70,000 | 16,000 | -54,000 | 0.24 | 0.05 | -0.19 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 172,711 | 108,817 | -63,894 | 0.07 | 0.04 | -0.03 | sell |
| Siren, L.L.C. | 747,325 | 594,994 | -152,331 | 1.50 | 1.25 | -0.24 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,052,595 | 821,850 | -230,745 | 0.01 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,605,310 | 2,339,563 | -265,747 | 0.97 | 0.84 | -0.13 | sell |
| Paradigm Biocapital Advisors LP | 1,283,766 | 961,707 | -322,059 | 2.02 | 1.65 | -0.37 | sell |