| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,732,456 | 10,300,984 | +7,568,528 | 0.13 | 0.60 | +0.47 | buy |
| FMR LLC | 8,225,038 | 9,262,291 | +1,037,253 | 0.03 | 0.04 | +0.01 | buy |
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 31.67 | 26.68 | -4.98 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 4,746,585 | 4,375,703 | -370,882 | 0.06 | 0.07 | +0.01 | sell |
| BlackRock, Inc. | 3,783,994 | 4,085,651 | +301,657 | 0.00 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 2,712,097 | 2,782,097 | +70,000 | 2.05 | 2.33 | +0.28 | buy |
| JANUS HENDERSON GROUP PLC | 2,062,604 | 2,360,596 | +297,992 | 0.07 | 0.09 | +0.03 | buy |
| STATE STREET CORP | 1,690,186 | 2,162,964 | +472,778 | 0.00 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,183,704 | 1,920,800 | -262,904 | 1.12 | 1.19 | +0.07 | sell |
| PERCEPTIVE ADVISORS LLC | 2,330,651 | 1,540,384 | -790,267 | 3.22 | 2.56 | -0.66 | sell |
| Paradigm Biocapital Advisors LP | 1,123,243 | 1,348,243 | +225,000 | 2.27 | 2.32 | +0.05 | buy |
| Affinity Asset Advisors, LLC | 1,234,926 | 1,284,926 | +50,000 | 6.70 | 6.34 | -0.35 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,059,085 | 1,217,289 | +158,204 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 974,826 | 1,144,328 | +169,502 | 0.01 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,237,135 | 1,143,152 | -93,983 | 0.01 | 0.01 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,373,066 | 1,110,470 | -262,596 | 0.01 | 0.01 | -0.00 | sell |
| Vestal Point Capital, LP | 550,000 | 1,100,000 | +550,000 | 1.52 | 2.59 | +1.07 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 480,453 | 1,064,483 | +584,030 | 0.38 | 0.92 | +0.54 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,093,657 | 990,297 | -103,360 | 0.03 | 0.02 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 793,695 | 900,871 | +107,176 | 0.00 | 0.01 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 890,665 | 831,428 | -59,237 | 0.10 | 0.10 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 565,410 | 652,590 | +87,180 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 766,981 | 598,902 | -168,079 | 0.04 | 0.04 | -0.00 | sell |
| MORGAN STANLEY | 890,264 | 595,032 | -295,232 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 578,627 | 585,016 | +6,389 | 0.03 | 0.03 | +0.01 | buy |
| First Light Asset Management, LLC | 284,991 | 576,684 | +291,693 | 1.64 | 4.35 | +2.71 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 436,015 | 557,423 | +121,408 | 0.51 | 0.78 | +0.26 | buy |
| Polar Capital Holdings Plc | 503,539 | 539,177 | +35,638 | 0.17 | 0.20 | +0.02 | buy |
| First Turn Management, LLC | 474,839 | 513,770 | +38,931 | 4.10 | 4.83 | +0.74 | buy |
| BRAIDWELL LP | 575,067 | 478,667 | -96,400 | 1.39 | 1.34 | -0.04 | sell |
| Novo Holdings A/S | 570,000 | 450,000 | -120,000 | 3.34 | 3.07 | -0.27 | sell |
| FEDERATED HERMES, INC. | 127,931 | 442,738 | +314,807 | 0.02 | 0.06 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 438,654 | +438,654 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,362 | 420,684 | +39,322 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 451,002 | 405,538 | -45,464 | 0.01 | 0.01 | +0.00 | sell |
| NORTHERN TRUST CORP | 327,376 | 390,879 | +63,503 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 388,257 | 390,000 | +1,743 | 3.87 | 4.32 | +0.46 | buy |
| GREAT POINT PARTNERS LLC | 374,000 | 374,000 | 0 | 9.15 | 7.71 | -1.44 | hold |
| LOOMIS SAYLES & CO L P | 255,439 | 362,781 | +107,342 | 0.02 | 0.04 | +0.02 | buy |
| Capital World Investors | 127,618 | 348,674 | +221,056 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 2,048,647 | 298,647 | -1,750,000 | 11.77 | 1.82 | -9.95 | sell |
| Deep Track Capital, LP | 0 | 285,000 | +285,000 | 0.00 | 0.49 | +0.49 | buy |
| TWO SIGMA INVESTMENTS, LP | 105,241 | 281,386 | +176,145 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 210,466 | 261,120 | +50,654 | 0.06 | 0.08 | +0.02 | buy |
| Pictet Asset Management Holding SA | 312,883 | 261,050 | -51,833 | 0.02 | 0.02 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 240,000 | 250,000 | +10,000 | 0.03 | 0.03 | +0.01 | buy |
| Candriam S.C.A. | 191,318 | 223,541 | +32,223 | 0.07 | 0.10 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,965 | 220,099 | +210,134 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 129,290 | 184,792 | +55,502 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 36,103 | 143,379 | +107,276 | 0.00 | 0.02 | +0.02 | buy |
| Nicholas Investment Partners, LP | 112,924 | 130,992 | +18,068 | 0.62 | 0.80 | +0.17 | buy |
| Nuveen, LLC | 121,050 | 128,115 | +7,065 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 127,629 | 128,015 | +386 | 0.02 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 118,084 | 126,757 | +8,673 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 124,979 | 122,669 | -2,310 | 0.20 | 0.22 | +0.02 | sell |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.18 | 0.24 | +0.06 | hold |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 100,000 | +50,000 | 0.29 | 0.56 | +0.28 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 105,000 | 96,656 | -8,344 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 108,267 | 95,137 | -13,130 | 0.00 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 140,727 | 92,592 | -48,135 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 79,361 | 91,421 | +12,060 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 76,898 | 88,561 | +11,663 | 0.02 | 0.06 | +0.05 | buy |
| Ensign Peak Advisors, Inc | 2,250 | 82,300 | +80,050 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 50,744 | 80,201 | +29,457 | 0.00 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 62,799 | 77,808 | +15,009 | 0.13 | 0.20 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 130,069 | 77,686 | -52,383 | 0.93 | 0.68 | -0.26 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 76,030 | +76,030 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 62,900 | 75,600 | +12,700 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 94,720 | 75,086 | -19,634 | 0.31 | 0.31 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.02 | +0.02 | buy |
| Rhenman & Partners Asset Management AB | 0 | 75,000 | +75,000 | 0.00 | 0.78 | +0.78 | buy |
| Boxer Capital Management, LLC | 70,000 | 70,000 | 0 | 1.16 | 0.77 | -0.38 | hold |
| AMERIPRISE FINANCIAL INC | 122,900 | 69,888 | -53,012 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80,832 | 68,696 | -12,136 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 54,300 | 63,900 | +9,600 | 0.00 | 0.01 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 63,800 | +63,800 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 48,619 | 60,397 | +11,778 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 63,250 | 58,835 | -4,415 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 49,999 | 58,484 | +8,485 | 0.00 | 0.01 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 69,212 | 58,314 | -10,898 | 1.21 | 1.24 | +0.03 | sell |
| Holocene Advisors, LP | 0 | 57,473 | +57,473 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 49,805 | 56,352 | +6,547 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 39,846 | 54,437 | +14,591 | 0.00 | 0.01 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 0 | 52,260 | +52,260 | 0.00 | 1.11 | +1.11 | buy |
| BARCLAYS PLC | 133,193 | 50,396 | -82,797 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 45,971 | 48,678 | +2,707 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 44,922 | 45,586 | +664 | 0.02 | 0.02 | -0.00 | buy |
| XTX Topco Ltd | 19,026 | 42,899 | +23,873 | 0.04 | 0.06 | +0.03 | buy |
| SEI INVESTMENTS CO | 16,329 | 42,203 | +25,874 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 11,163 | 41,815 | +30,652 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 3,418 | 40,776 | +37,358 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 70,687 | 38,763 | -31,924 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 38,348 | +38,348 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,758 | 38,161 | +7,403 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 37,843 | +37,843 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 89,229 | 35,761 | -53,468 | 1.73 | 0.83 | -0.90 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,709 | 34,217 | +13,508 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 30,000 | +30,000 | 0.00 | 0.13 | +0.13 | buy |
| Legato Capital Management LLC | 13,551 | 29,968 | +16,417 | 0.09 | 0.23 | +0.14 | buy |
| MOODY ALDRICH PARTNERS LLC | 17,164 | 29,080 | +11,916 | 0.24 | 0.44 | +0.20 | buy |