| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 2,269,897 | 3,546,949 | +1,277,052 | 0.03 | 0.02 | -0.00 | buy |
| FMR LLC | 6,743,902 | 7,505,875 | +761,973 | 0.03 | 0.02 | -0.01 | buy |
| BRAIDWELL LP | 1,842,515 | 2,392,042 | +549,527 | 3.95 | 2.95 | -0.99 | buy |
| ALLIANCEBERNSTEIN L.P. | 745,118 | 1,132,270 | +387,152 | 0.02 | 0.02 | -0.00 | buy |
| Polar Capital Holdings Plc | 0 | 250,000 | +250,000 | 0.00 | 0.06 | +0.06 | buy |
| RTW INVESTMENTS, LP | 2,467,591 | 2,712,096 | +244,505 | 2.42 | 1.65 | -0.77 | buy |
| Affinity Asset Advisors, LLC | 592,093 | 836,283 | +244,190 | 6.40 | 5.18 | -1.21 | buy |
| GOLDMAN SACHS GROUP INC | 112,992 | 337,153 | +224,161 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,347,797 | 1,561,362 | +213,565 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 89,480 | 302,222 | +212,742 | 0.01 | 0.03 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 180,077 | +180,077 | 0.00 | 0.14 | +0.14 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 174,814 | +174,814 | 0.00 | 0.03 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 0 | 150,135 | +150,135 | 0.00 | 0.10 | +0.10 | buy |
| CITADEL ADVISORS LLC | 0 | 116,318 | +116,318 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 112,858 | +112,858 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 384,893 | 487,000 | +102,107 | 0.91 | 0.81 | -0.09 | buy |
| VANGUARD GROUP INC | 1,868,666 | 1,970,320 | +101,654 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 136,138 | 234,780 | +98,642 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 0 | 87,201 | +87,201 | 0.00 | 0.05 | +0.05 | buy |
| MARSHALL WACE, LLP | 0 | 81,946 | +81,946 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 88,700 | 156,204 | +67,504 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 12,000 | 69,750 | +57,750 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 99,659 | 156,266 | +56,607 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,063,763 | 2,117,870 | +54,107 | 1.37 | 0.81 | -0.56 | buy |
| D. E. Shaw & Co., Inc. | 0 | 52,026 | +52,026 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 4,100 | 52,400 | +48,300 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,060,395 | 2,105,636 | +45,241 | 2.41 | 2.00 | -0.41 | buy |
| Woodline Partners LP | 702,421 | 746,159 | +43,738 | 0.43 | 0.28 | -0.15 | buy |
| Jump Financial, LLC | 0 | 43,458 | +43,458 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 36,646 | 77,803 | +41,157 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 40,000 | 80,000 | +40,000 | 0.26 | 0.31 | +0.05 | buy |
| ALPS ADVISORS INC | 0 | 35,067 | +35,067 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 6,000 | 40,875 | +34,875 | 0.11 | 0.32 | +0.22 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 34,403 | +34,403 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 30,178 | +30,178 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 3,188 | 32,439 | +29,251 | 0.00 | 0.03 | +0.02 | buy |
| Squarepoint Ops LLC | 18,193 | 44,022 | +25,829 | 0.00 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 0 | 17,930 | +17,930 | 0.00 | 0.06 | +0.06 | buy |
| PRUDENTIAL FINANCIAL INC | 6,765 | 24,480 | +17,715 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 56,179 | 73,893 | +17,714 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 16,779 | +16,779 | 0.00 | 0.06 | +0.06 | buy |
| HRT FINANCIAL LP | 0 | 15,745 | +15,745 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,333 | 25,560 | +12,227 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,535 | +11,535 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,312 | +10,312 | 0.00 | 0.03 | +0.03 | buy |
| OMERS ADMINISTRATION Corp | 0 | 9,500 | +9,500 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,350 | +9,350 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 66,128 | 74,838 | +8,710 | 0.02 | 0.01 | -0.01 | buy |
| Handelsbanken Fonder AB | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,904 | +6,904 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 6,437 | +6,437 | 0.00 | 0.01 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 7,897 | 14,083 | +6,186 | 0.09 | 0.10 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 256 | 6,031 | +5,775 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 6,110 | 11,400 | +5,290 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 5,100 | +5,100 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 24,333 | 28,343 | +4,010 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,982 | +3,982 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 3,629 | +3,629 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 302,892 | 306,078 | +3,186 | 0.01 | 0.01 | -0.01 | buy |
| PROFUND ADVISORS LLC | 10,920 | 14,010 | +3,090 | 0.03 | 0.02 | -0.01 | buy |
| STRS OHIO | 3,900 | 6,100 | +2,200 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 6,474 | 8,673 | +2,199 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 1,568 | 3,402 | +1,834 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,507 | +1,507 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,343 | +1,343 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 5,102 | 6,442 | +1,340 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 41,300 | 42,200 | +900 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 20,259 | 21,088 | +829 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 25 | 358 | +333 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 305 | +305 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 5,735 | 5,993 | +258 | 0.00 | 0.00 | -0.00 | buy |
| Family Management Corp | 6,740 | 6,953 | +213 | 0.08 | 0.05 | -0.03 | buy |
| GROUP ONE TRADING LLC | 0 | 119 | +119 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 310 | 426 | +116 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 15 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1 | 10 | +9 | 0.00 | 0.00 | 0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 329,000 | 329,000 | 0 | 0.38 | 0.22 | -0.16 | hold |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.69 | 0.40 | -0.29 | hold |
| NORGES BANK | 12,121 | 12,121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 137 | 137 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 78,000 | 78,000 | 0 | 1.81 | 1.16 | -0.65 | hold |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.08 | 0.05 | -0.03 | hold |
| Global Endowment Management, LP | 7,797 | 7,797 | 0 | 0.05 | 0.03 | -0.02 | hold |
| Candriam S.C.A. | 90,000 | 90,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 26.85 | 21.28 | -5.56 | hold |
| BELLEVUE ASSET MANAGEMENT, LLC | 36 | 36 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 14.84 | 9.11 | -5.73 | hold |
| Commodore Capital LP | 290,000 | 290,000 | 0 | 1.29 | 0.78 | -0.51 | hold |
| Paradigm Biocapital Advisors LP | 330,000 | 330,000 | 0 | 0.77 | 0.50 | -0.27 | hold |
| Washington Trust Advisors, Inc. | 96 | 96 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 3 | 3 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Red Tortoise LLC | 94 | 94 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 14,807 | 14,807 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| GAMMA Investing LLC | 13 | 11 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 100 | 0 | -100 | 0.02 | 0.00 | -0.02 | sell |
| AMALGAMATED BANK | 1,388 | 1,251 | -137 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 21,229 | 21,035 | -194 | 0.01 | 0.00 | -0.00 | sell |