| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,699,345 | 2,105,636 | +593,709 | 3.14 | 1.98 | 0.00 | sell |
| BRAIDWELL LP | 1,842,515 | 2,392,042 | +549,527 | 3.95 | 2.95 | -0.99 | buy |
| RTW INVESTMENTS, LP | 2,467,591 | 2,712,096 | +244,505 | 2.42 | 1.65 | -0.77 | buy |
| Affinity Asset Advisors, LLC | 592,093 | 836,283 | +244,190 | 4.87 | 3.79 | -1.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 89,480 | 302,222 | +212,742 | 0.02 | 0.03 | 0.00 | buy |
| Avidity Partners Management LP | 384,893 | 487,000 | +102,107 | 0.91 | 0.81 | -0.09 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,063,763 | 2,117,870 | +54,107 | 1.37 | 0.81 | -0.56 | buy |
| PERCEPTIVE ADVISORS LLC | 2,060,395 | 2,105,636 | +45,241 | 2.40 | 2.00 | -0.40 | buy |
| Woodline Partners LP | 702,421 | 746,159 | +43,738 | 0.43 | 0.28 | -0.15 | buy |
| Integral Health Asset Management, LLC | 40,000 | 80,000 | +40,000 | 0.25 | 0.30 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 6,000 | 40,875 | +34,875 | 0.11 | 0.32 | +0.22 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 3,188 | 32,439 | +29,251 | 0.00 | 0.03 | +0.02 | buy |
| Rafferty Asset Management, LLC | 66,128 | 74,838 | +8,710 | 0.02 | 0.01 | -0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 7,897 | 14,083 | +6,186 | 0.09 | 0.10 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 302,892 | 306,078 | +3,186 | 0.01 | 0.01 | -0.01 | buy |
| PROFUND ADVISORS LLC | 10,920 | 14,010 | +3,090 | 0.03 | 0.02 | 0.00 | buy |
| Family Management Corp | 6,740 | 6,953 | +213 | 0.08 | 0.05 | -0.03 | buy |
| VIRTUS ADVISERS, LLC | 3,727 | 2,099 | -1,628 | 0.13 | 0.04 | -0.09 | sell |
| China Universal Asset Management Co., Ltd. | 7,155 | 5,284 | -1,871 | 0.06 | 0.03 | -0.03 | sell |
| Artia Global Partners LP | 61,590 | 58,400 | -3,190 | 1.00 | 0.59 | -0.41 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 44,868 | 36,928 | -7,940 | 1.97 | 1.83 | -0.14 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 167,878 | 147,472 | -20,406 | 0.45 | 0.23 | -0.21 | sell |
| HighVista Strategies LLC | 119,403 | 78,942 | -40,461 | 2.83 | 1.13 | -1.69 | sell |
| TD ASSET MANAGEMENT INC | 148,206 | 95,006 | -53,200 | 0.01 | 0.00 | -0.01 | sell |
| First Turn Management, LLC | 379,803 | 318,327 | -61,476 | 3.78 | 2.04 | -1.74 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 175,000 | 50,000 | -125,000 | 0.02 | 0.00 | -0.02 | sell |
| Blackstone Inc. | 230,000 | 80,000 | -150,000 | 0.06 | 0.01 | -0.05 | sell |
| ORBIMED ADVISORS LLC | 718,901 | 379,130 | -339,771 | 0.88 | 0.30 | -0.58 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,170,327 | 768,221 | -402,106 | 0.01 | 0.00 | -0.01 | sell |
| Deep Track Capital, LP | 2,323,456 | 1,000,000 | -1,323,456 | 4.44 | 1.18 | -3.26 | sell |