| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 27.00 | 27.64 | +0.64 | hold |
| FMR LLC | 7,493,626 | 6,907,100 | -586,526 | 0.02 | 0.02 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,485,754 | 3,805,710 | -1,680,044 | 0.04 | 0.03 | -0.01 | sell |
| RTW INVESTMENTS, LP | 2,712,097 | 2,712,097 | 0 | 1.55 | 1.68 | +0.13 | hold |
| BlackRock, Inc. | 2,910,829 | 2,562,539 | -348,290 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,339,563 | 2,310,755 | -28,808 | 0.84 | 0.80 | -0.04 | sell |
| VANGUARD GROUP INC | 2,082,606 | 2,108,938 | +26,332 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 11.87 | 11.53 | -0.35 | hold |
| BRAIDWELL LP | 1,540,362 | 1,478,512 | -61,850 | 2.02 | 2.20 | +0.17 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,280,950 | 1,388,149 | +107,199 | 0.02 | 0.02 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 727,000 | 1,290,464 | +563,464 | 0.05 | 0.09 | +0.04 | buy |
| STATE STREET CORP | 1,313,750 | 1,259,258 | -54,492 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 392,488 | 1,230,377 | +837,889 | 0.04 | 0.13 | +0.09 | buy |
| PERCEPTIVE ADVISORS LLC | 1,122,767 | 1,182,148 | +59,381 | 1.49 | 1.93 | +0.44 | buy |
| JPMORGAN CHASE & CO | 962,631 | 1,125,570 | +162,939 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 961,707 | 958,630 | -3,077 | 1.65 | 1.78 | +0.12 | sell |
| Woodline Partners LP | 1,061,053 | 870,208 | -190,845 | 0.26 | 0.20 | -0.06 | sell |
| FRANKLIN RESOURCES INC | 876,076 | 852,531 | -23,545 | 0.01 | 0.01 | +0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 1,640,180 | 820,376 | -819,804 | 0.14 | 0.08 | -0.06 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 835,695 | 782,641 | -53,054 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 821,850 | 760,844 | -61,006 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 1,151,199 | 691,899 | -459,300 | 6.73 | 4.44 | -2.29 | sell |
| GOLDMAN SACHS GROUP INC | 290,699 | 659,186 | +368,487 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 421,796 | 642,357 | +220,561 | 0.27 | 0.46 | +0.19 | buy |
| BARCLAYS PLC | 498,625 | 608,822 | +110,197 | 0.01 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 594,994 | 594,994 | 0 | 1.25 | 1.34 | +0.08 | hold |
| JANUS HENDERSON GROUP PLC | 1,793,833 | 509,321 | -1,284,512 | 0.04 | 0.01 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 425,880 | 508,987 | +83,107 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 66,182 | 495,659 | +429,477 | 0.00 | 0.02 | +0.02 | buy |
| Polar Capital Holdings Plc | 550,000 | 495,000 | -55,000 | 0.13 | 0.11 | -0.01 | sell |
| MORGAN STANLEY | 519,939 | 474,702 | -45,237 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 0 | 449,392 | +449,392 | 0.00 | 1.38 | +1.38 | buy |
| First Turn Management, LLC | 229,675 | 311,490 | +81,815 | 1.73 | 2.52 | +0.79 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 108,817 | 309,066 | +200,249 | 0.04 | 0.12 | +0.08 | buy |
| Commodore Capital LP | 290,000 | 290,000 | 0 | 0.80 | 0.89 | +0.09 | hold |
| JENNISON ASSOCIATES LLC | 293,757 | 270,366 | -23,391 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 271,879 | 266,384 | -5,495 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 314,478 | 264,188 | -50,290 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 232,983 | 254,770 | +21,787 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 260,335 | 245,133 | -15,202 | 0.01 | 0.01 | +0.00 | sell |
| Ikarian Capital, LLC | 0 | 232,047 | +232,047 | 0.00 | 3.33 | +3.33 | buy |
| Bank of New York Mellon Corp | 214,231 | 201,151 | -13,080 | 0.00 | 0.00 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.41 | 0.44 | +0.03 | hold |
| D. E. Shaw & Co., Inc. | 8,776 | 194,528 | +185,752 | 0.00 | 0.01 | +0.01 | buy |
| Capital World Investors | 193,895 | 193,895 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blackstone Inc. | 183,747 | 178,546 | -5,201 | 0.03 | 0.03 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 112,730 | 158,635 | +45,905 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 96,326 | 156,108 | +59,782 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 108,340 | 131,138 | +22,798 | 0.20 | 0.23 | +0.03 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 127,208 | 125,829 | -1,379 | 0.01 | 0.01 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 96,992 | 119,246 | +22,254 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 252,135 | 115,694 | -136,441 | 0.02 | 0.01 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.07 | 0.09 | +0.02 | hold |
| UBS Group AG | 701,909 | 107,157 | -594,752 | 0.01 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 101,388 | 94,588 | -6,800 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 11,599 | 90,568 | +78,969 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 95,646 | 86,512 | -9,134 | 0.21 | 0.25 | +0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 85,183 | +85,183 | 0.00 | 0.11 | +0.11 | buy |
| STEMPOINT CAPITAL LP | 0 | 84,466 | +84,466 | 0.00 | 1.18 | +1.18 | buy |
| Nuveen, LLC | 110,855 | 83,291 | -27,564 | 0.00 | 0.00 | -0.00 | sell |
| Weiss Asset Management LP | 0 | 82,302 | +82,302 | 0.00 | 0.06 | +0.06 | buy |
| Sofinnova Investments, Inc. | 0 | 76,180 | +76,180 | 0.00 | 0.23 | +0.23 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 78,397 | 75,897 | -2,500 | 0.07 | 0.08 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 87,347 | 72,939 | -14,408 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 24,905 | 68,845 | +43,940 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 65,000 | +65,000 | 0.00 | 0.57 | +0.57 | buy |
| Parkman Healthcare Partners LLC | 46,663 | 55,404 | +8,741 | 0.21 | 0.28 | +0.07 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,726 | 55,062 | +19,336 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 54,385 | 49,216 | -5,169 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 43,190 | 45,052 | +1,862 | 0.62 | 0.72 | +0.10 | buy |
| Swiss National Bank | 43,600 | 42,600 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 43,001 | 42,211 | -790 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 41,100 | +41,100 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,338 | 38,697 | -31,641 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 37,622 | +37,622 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 35,000 | +35,000 | 0.00 | 0.49 | +0.49 | buy |
| B Group, Inc. | 30,000 | 35,000 | +5,000 | 0.97 | 1.31 | +0.34 | buy |
| J. Goldman & Co LP | 0 | 34,605 | +34,605 | 0.00 | 0.05 | +0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 33,085 | +33,085 | 0.00 | 0.02 | +0.02 | buy |
| COMERICA BANK | 15,360 | 29,469 | +14,109 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 29,268 | 29,268 | 0 | 0.19 | 0.20 | +0.01 | hold |
| Legal & General Group Plc | 25,782 | 27,689 | +1,907 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 24,310 | 26,866 | +2,556 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 33,096 | 24,850 | -8,246 | 0.01 | 0.01 | -0.00 | sell |
| Erste Asset Management GmbH | 24,000 | 24,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 28,869 | 23,709 | -5,160 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 61,362 | 22,928 | -38,434 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 204 | 21,768 | +21,564 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 21,632 | +21,632 | 0.00 | 0.18 | +0.18 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,178 | 21,386 | -792 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,529 | 19,555 | -4,974 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 22,605 | 19,238 | -3,367 | 0.00 | 0.00 | +0.00 | sell |
| Lisanti Capital Growth, LLC | 0 | 18,410 | +18,410 | 0.00 | 0.22 | +0.22 | buy |
| ADAR1 Capital Management, LLC | 104,853 | 18,070 | -86,783 | 0.75 | 0.13 | -0.63 | sell |
| WELLS FARGO & COMPANY/MN | 18,104 | 16,853 | -1,251 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 18,417 | 16,070 | -2,347 | 0.01 | 0.01 | -0.00 | sell |
| Birchview Capital, LP | 8,000 | 16,000 | +8,000 | 0.26 | 0.69 | +0.43 | buy |
| NATIXIS ADVISORS, LLC | 15,016 | 15,031 | +15 | 0.00 | 0.00 | -0.00 | buy |
| WINTON GROUP Ltd | 0 | 14,617 | +14,617 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 9,032 | 14,248 | +5,216 | 0.03 | 0.06 | +0.03 | buy |