| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 392,488 | 1,230,377 | +837,889 | 0.04 | 0.13 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 727,000 | 1,290,464 | +563,464 | 0.05 | 0.09 | +0.04 | buy |
| Novo Holdings A/S | 0 | 449,392 | +449,392 | 0.00 | 1.38 | +1.38 | buy |
| CITADEL ADVISORS LLC | 66,182 | 495,659 | +429,477 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 290,699 | 659,186 | +368,487 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 232,047 | +232,047 | 0.00 | 3.33 | +3.33 | buy |
| Jefferies Financial Group Inc. | 421,796 | 642,357 | +220,561 | 0.27 | 0.46 | +0.19 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 108,817 | 309,066 | +200,249 | 0.04 | 0.12 | +0.08 | buy |
| D. E. Shaw & Co., Inc. | 8,776 | 194,528 | +185,752 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 962,631 | 1,125,570 | +162,939 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 498,625 | 608,822 | +110,197 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,280,950 | 1,388,149 | +107,199 | 0.02 | 0.02 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 85,183 | +85,183 | 0.00 | 0.11 | +0.11 | buy |
| STEMPOINT CAPITAL LP | 0 | 84,466 | +84,466 | 0.00 | 1.18 | +1.18 | buy |
| BANK OF AMERICA CORP /DE/ | 425,880 | 508,987 | +83,107 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 82,302 | +82,302 | 0.00 | 0.06 | +0.06 | buy |
| First Turn Management, LLC | 229,675 | 311,490 | +81,815 | 1.73 | 2.52 | +0.79 | buy |
| MARSHALL WACE, LLP | 11,599 | 90,568 | +78,969 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 76,180 | +76,180 | 0.00 | 0.23 | +0.23 | buy |
| Avidity Partners Management LP | 0 | 65,000 | +65,000 | 0.00 | 0.57 | +0.57 | buy |
| AMERIPRISE FINANCIAL INC | 96,326 | 156,108 | +59,782 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,122,767 | 1,182,148 | +59,381 | 1.49 | 1.93 | +0.44 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 112,730 | 158,635 | +45,905 | 0.01 | 0.02 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 24,905 | 68,845 | +43,940 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 41,100 | +41,100 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 37,622 | +37,622 | 0.00 | 0.00 | +0.00 | buy |
| Blue Owl Capital Holdings LP | 0 | 35,000 | +35,000 | 0.00 | 0.49 | +0.49 | buy |
| J. Goldman & Co LP | 0 | 34,605 | +34,605 | 0.00 | 0.05 | +0.05 | buy |
| Brevan Howard Capital Management LP | 0 | 33,085 | +33,085 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 2,082,606 | 2,108,938 | +26,332 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 108,340 | 131,138 | +22,798 | 0.20 | 0.23 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 96,992 | 119,246 | +22,254 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 232,983 | 254,770 | +21,787 | 0.01 | 0.01 | -0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 21,632 | +21,632 | 0.00 | 0.18 | +0.18 | buy |
| Russell Investments Group, Ltd. | 204 | 21,768 | +21,564 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,726 | 55,062 | +19,336 | 0.00 | 0.00 | +0.00 | buy |
| Lisanti Capital Growth, LLC | 0 | 18,410 | +18,410 | 0.00 | 0.22 | +0.22 | buy |
| WINTON GROUP Ltd | 0 | 14,617 | +14,617 | 0.00 | 0.03 | +0.03 | buy |
| COMERICA BANK | 15,360 | 29,469 | +14,109 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 11,829 | +11,829 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,055 | +10,055 | 0.00 | 0.07 | +0.07 | buy |
| Mariner, LLC | 0 | 9,267 | +9,267 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 9,031 | +9,031 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 46,663 | 55,404 | +8,741 | 0.21 | 0.28 | +0.07 | buy |
| Birchview Capital, LP | 8,000 | 16,000 | +8,000 | 0.26 | 0.69 | +0.43 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,207 | 8,960 | +7,753 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 2,415 | 10,029 | +7,614 | 0.00 | 0.04 | +0.04 | buy |
| Tower Research Capital LLC (TRC) | 985 | 8,419 | +7,434 | 0.00 | 0.01 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 5,477 | +5,477 | 0.00 | 0.03 | +0.03 | buy |
| Optimize Financial Inc | 0 | 5,284 | +5,284 | 0.00 | 0.14 | +0.14 | buy |
| China Universal Asset Management Co., Ltd. | 9,032 | 14,248 | +5,216 | 0.03 | 0.06 | +0.03 | buy |
| HRT FINANCIAL LP | 0 | 5,211 | +5,211 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 30,000 | 35,000 | +5,000 | 0.97 | 1.31 | +0.34 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 4,931 | +4,931 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 4,720 | +4,720 | 0.00 | 0.02 | +0.02 | buy |
| E Fund Management Co., Ltd. | 0 | 4,700 | +4,700 | 0.00 | 0.01 | +0.01 | buy |
| AlphaQuest LLC | 1,141 | 5,073 | +3,932 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,491 | 12,305 | +3,814 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 24,310 | 26,866 | +2,556 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,930 | +1,930 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 25,782 | 27,689 | +1,907 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 43,190 | 45,052 | +1,862 | 0.62 | 0.72 | +0.10 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 2,584 | 3,813 | +1,229 | 0.03 | 0.03 | +0.00 | buy |
| Handelsbanken Fonder AB | 7,500 | 8,500 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,708 | 3,649 | +941 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 464 | +464 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 6,502 | 6,900 | +398 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 386 | 769 | +383 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 49 | 422 | +373 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,507 | 1,779 | +272 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 202 | +202 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 188 | +188 | 0.00 | 0.01 | +0.01 | buy |
| Larson Financial Group LLC | 30 | 194 | +164 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 16 | 80 | +64 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 542 | 597 | +55 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 7 | 54 | +47 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 39 | 77 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 6,452 | 6,488 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 131 | 166 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 15,016 | 15,031 | +15 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 25 | 28 | +3 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.41 | 0.44 | +0.03 | hold |
| Capital World Investors | 193,895 | 193,895 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parkside Financial Bank & Trust | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.07 | 0.09 | +0.02 | hold |
| RTW INVESTMENTS, LP | 2,712,097 | 2,712,097 | 0 | 1.55 | 1.68 | +0.13 | hold |
| Global Endowment Management, LP | 7,797 | 7,797 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Family Management Corp | 6,860 | 6,860 | 0 | 0.04 | 0.05 | +0.00 | hold |
| Arax Advisory Partners | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 27.00 | 27.64 | +0.64 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BELLEVUE ASSET MANAGEMENT, LLC | 36 | 36 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 11.87 | 11.53 | -0.35 | hold |
| Commodore Capital LP | 290,000 | 290,000 | 0 | 0.80 | 0.89 | +0.09 | hold |