| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 1,793,833 | 509,321 | +1,284,512 | 0.04 | 0.01 | 0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 727,000 | 1,290,464 | +563,464 | 0.05 | 0.09 | +0.04 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 108,817 | 309,066 | +200,249 | 0.04 | 0.12 | +0.08 | buy |
| First Turn Management, LLC | 229,675 | 311,490 | +81,815 | 1.73 | 2.52 | +0.79 | buy |
| PERCEPTIVE ADVISORS LLC | 1,122,767 | 1,182,148 | +59,381 | 1.48 | 1.90 | +0.42 | buy |
| Granahan Investment Management, LLC | 108,340 | 131,138 | +22,798 | 0.20 | 0.23 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 96,992 | 119,246 | +22,254 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 46,663 | 55,404 | +8,741 | 0.21 | 0.28 | +0.07 | buy |
| ALPS ADVISORS INC | 33,096 | 24,850 | +8,246 | 0.01 | 0.01 | 0.00 | sell |
| Birchview Capital, LP | 8,000 | 16,000 | +8,000 | 0.26 | 0.69 | +0.43 | buy |
| China Universal Asset Management Co., Ltd. | 9,032 | 14,248 | +5,216 | 0.03 | 0.06 | +0.03 | buy |
| B Group, Inc. | 30,000 | 35,000 | +5,000 | 0.97 | 1.31 | +0.34 | buy |
| HighVista Strategies LLC | 43,190 | 45,052 | +1,862 | 0.62 | 0.72 | +0.10 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 2,584 | 3,813 | +1,229 | 0.03 | 0.03 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 542 | 597 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Red Tortoise LLC | 94 | 69 | -25 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 9,215 | 8,981 | -234 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 43,001 | 42,211 | -790 | 0.01 | 0.01 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 3,701 | 2,246 | -1,455 | 0.04 | 0.03 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 78,397 | 75,897 | -2,500 | 0.07 | 0.08 | +0.01 | sell |
| Paradigm Biocapital Advisors LP | 961,707 | 958,630 | -3,077 | 1.65 | 1.78 | +0.12 | sell |
| Blackstone Inc. | 183,747 | 178,546 | -5,201 | 0.03 | 0.03 | +0.00 | sell |
| Persistent Asset Partners Ltd | 9,178 | 2,425 | -6,753 | 0.30 | 0.09 | -0.21 | sell |
| TD ASSET MANAGEMENT INC | 101,388 | 94,588 | -6,800 | 0.00 | 0.00 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 95,646 | 86,512 | -9,134 | 0.21 | 0.25 | +0.04 | sell |
| JENNISON ASSOCIATES LLC | 293,757 | 270,366 | -23,391 | 0.01 | 0.01 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,339,563 | 2,310,755 | -28,808 | 0.84 | 0.80 | -0.04 | sell |
| DIADEMA PARTNERS LP | 40,000 | 10,572 | -29,428 | 1.19 | 0.29 | -0.91 | sell |
| Polar Capital Holdings Plc | 550,000 | 495,000 | -55,000 | 0.13 | 0.11 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 821,850 | 760,844 | -61,006 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 1,540,362 | 1,478,512 | -61,850 | 2.02 | 2.20 | +0.17 | sell |
| ADAR1 Capital Management, LLC | 104,853 | 18,070 | -86,783 | 0.75 | 0.13 | -0.63 | sell |
| Allostery Investments LP | 110,000 | 6,000 | -104,000 | 5.93 | 3.32 | -2.61 | sell |
| Woodline Partners LP | 1,061,053 | 870,208 | -190,845 | 0.26 | 0.20 | -0.06 | sell |
| Affinity Asset Advisors, LLC | 1,151,199 | 691,899 | -459,300 | 6.73 | 4.44 | -2.29 | sell |