| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,117,870 | 2,533,607 | +415,737 | 0.81 | 1.28 | +0.47 | buy |
| Paradigm Biocapital Advisors LP | 330,000 | 701,817 | +371,817 | 0.50 | 1.44 | +0.95 | buy |
| Woodline Partners LP | 746,159 | 976,155 | +229,996 | 0.28 | 0.48 | +0.20 | buy |
| TWO SIGMA INVESTMENTS, LP | 302,222 | 199,308 | +102,914 | 0.03 | 0.03 | 0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 112,858 | 58,466 | +54,392 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 40,875 | 57,183 | +16,308 | 0.32 | 0.56 | +0.24 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 32,439 | 41,194 | +8,755 | 0.03 | 0.05 | +0.03 | buy |
| JENNISON ASSOCIATES LLC | 306,078 | 312,611 | +6,533 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,284 | 8,655 | +3,371 | 0.03 | 0.06 | +0.03 | buy |
| PROFUND ADVISORS LLC | 14,010 | 11,112 | +2,898 | 0.02 | 0.02 | 0.00 | sell |
| Family Management Corp | 6,953 | 8,079 | +1,126 | 0.05 | 0.08 | +0.03 | buy |
| ALPS ADVISORS INC | 35,067 | 35,485 | +418 | 0.01 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 14,083 | 14,230 | +147 | 0.10 | 0.11 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 2,099 | 2,138 | +39 | 0.04 | 0.06 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 95,006 | 93,446 | -1,560 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 768,221 | 758,081 | -10,140 | 0.00 | 0.01 | +0.00 | sell |
| HighVista Strategies LLC | 78,942 | 61,788 | -17,154 | 1.13 | 1.25 | +0.12 | sell |
| Rafferty Asset Management, LLC | 74,838 | 54,563 | -20,275 | 0.01 | 0.01 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 147,472 | 107,694 | -39,778 | 0.23 | 0.29 | +0.05 | sell |
| PERCEPTIVE ADVISORS LLC | 2,105,636 | 2,015,007 | -90,629 | 2.00 | 2.50 | +0.51 | sell |
| Affinity Asset Advisors, LLC | 836,283 | 664,198 | -172,085 | 5.18 | 6.05 | +0.87 | sell |
| Avidity Partners Management LP | 487,000 | 154,000 | -333,000 | 0.81 | 0.46 | -0.35 | sell |
| BRAIDWELL LP | 2,392,042 | 1,643,226 | -748,816 | 2.95 | 2.74 | -0.22 | sell |