| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 21.28 | 26.13 | +4.85 | hold |
| FMR LLC | 7,505,875 | 7,502,482 | -3,393 | 0.02 | 0.03 | +0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,546,949 | 4,814,400 | +1,267,451 | 0.02 | 0.05 | +0.02 | buy |
| RTW INVESTMENTS, LP | 2,712,096 | 2,712,096 | 0 | 1.65 | 2.31 | +0.65 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,117,870 | 2,533,607 | +415,737 | 0.81 | 1.28 | +0.47 | buy |
| VANGUARD GROUP INC | 1,970,320 | 2,127,042 | +156,722 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 9.11 | 9.76 | +0.65 | hold |
| PERCEPTIVE ADVISORS LLC | 2,105,636 | 2,015,007 | -90,629 | 2.00 | 2.54 | +0.54 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,961,863 | 1,961,863 | 0 | 1.02 | 1.33 | +0.31 | hold |
| BRAIDWELL LP | 2,392,042 | 1,643,226 | -748,816 | 2.95 | 2.74 | -0.22 | sell |
| STATE STREET CORP | 1,561,362 | 1,411,639 | -149,723 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,132,270 | 1,194,363 | +62,093 | 0.02 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 1,000,000 | 1,000,000 | 0 | 1.18 | 1.88 | +0.70 | hold |
| Woodline Partners LP | 746,159 | 976,155 | +229,996 | 0.28 | 0.48 | +0.20 | buy |
| FRANKLIN RESOURCES INC | 1,005,470 | 860,989 | -144,481 | 0.01 | 0.01 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 740,861 | 823,839 | +82,978 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 768,221 | 758,081 | -10,140 | 0.00 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 269,232 | 707,268 | +438,036 | 0.03 | 0.14 | +0.11 | buy |
| Paradigm Biocapital Advisors LP | 330,000 | 701,817 | +371,817 | 0.50 | 1.44 | +0.95 | buy |
| Affinity Asset Advisors, LLC | 836,283 | 664,198 | -172,085 | 5.18 | 6.05 | +0.87 | sell |
| JANUS HENDERSON GROUP PLC | 11,400 | 469,557 | +458,157 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 379,130 | 379,130 | 0 | 0.30 | 0.41 | +0.11 | hold |
| Jefferies Financial Group Inc. | 180,077 | 369,197 | +189,120 | 0.14 | 0.35 | +0.21 | buy |
| BARCLAYS PLC | 77,803 | 365,046 | +287,243 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 156,266 | 346,358 | +190,092 | 0.01 | 0.02 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 306,078 | 312,611 | +6,533 | 0.01 | 0.01 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 311,316 | +311,316 | 0.00 | 0.17 | +0.17 | buy |
| NORTHERN TRUST CORP | 311,203 | 306,549 | -4,654 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 349,556 | 299,472 | -50,084 | 0.00 | 0.00 | +0.00 | sell |
| Commodore Capital LP | 290,000 | 290,000 | 0 | 0.78 | 1.06 | +0.29 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 238,742 | 280,428 | +41,686 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 234,780 | 238,270 | +3,490 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 302,222 | 199,308 | -102,914 | 0.03 | 0.03 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 337,153 | 157,457 | -179,696 | 0.00 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 487,000 | 154,000 | -333,000 | 0.81 | 0.46 | -0.35 | sell |
| Vestal Point Capital, LP | 0 | 136,500 | +136,500 | 0.00 | 0.63 | +0.63 | buy |
| Invesco Ltd. | 20,383 | 132,166 | +111,783 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 135,747 | 112,601 | -23,146 | 0.00 | 0.00 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.05 | 0.08 | +0.03 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 147,472 | 107,694 | -39,778 | 0.23 | 0.29 | +0.05 | sell |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.40 | 0.42 | +0.02 | hold |
| WELLS FARGO & COMPANY/MN | 11,580 | 98,290 | +86,710 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 95,006 | 93,446 | -1,560 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 0 | 91,757 | +91,757 | 0.00 | 0.21 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 97,065 | 90,009 | -7,056 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 90,000 | 90,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Cubist Systematic Strategies, LLC | 150,135 | 83,977 | -66,158 | 0.10 | 0.07 | -0.03 | sell |
| Blackstone Inc. | 80,000 | 80,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Ensign Peak Advisors, Inc | 69,750 | 69,750 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,643 | 67,988 | -3,655 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 78,942 | 61,788 | -17,154 | 1.13 | 1.25 | +0.12 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 112,858 | 58,466 | -54,392 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 40,875 | 57,183 | +16,308 | 0.32 | 0.56 | +0.24 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 25,560 | 56,517 | +30,957 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 74,838 | 54,563 | -20,275 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 50,490 | 51,820 | +1,330 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,123 | 51,530 | +36,407 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,435 | 50,970 | +1,535 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 52,026 | 49,662 | -2,364 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 52,400 | 47,200 | -5,200 | 0.00 | 0.01 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 174,814 | 41,747 | -133,067 | 0.03 | 0.01 | -0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 32,439 | 41,194 | +8,755 | 0.03 | 0.05 | +0.03 | buy |
| Swiss National Bank | 42,200 | 37,700 | -4,500 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 35,067 | 35,485 | +418 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34,403 | 32,241 | -2,162 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 28,343 | 29,555 | +1,212 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 18,111 | 28,134 | +10,023 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 106 | 28,058 | +27,952 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 24,480 | 24,535 | +55 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,969 | 22,904 | -1,065 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 21,035 | 21,115 | +80 | 0.00 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 16,194 | 21,030 | +4,836 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 21,088 | 20,870 | -218 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 19,458 | 20,261 | +803 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,016 | 19,609 | -2,407 | 0.00 | 0.00 | +0.00 | sell |
| Point72 (DIFC) Ltd | 16,779 | 19,207 | +2,428 | 0.06 | 0.09 | +0.03 | buy |
| Squarepoint Ops LLC | 44,022 | 19,043 | -24,979 | 0.01 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 73,893 | 18,375 | -55,518 | 0.00 | 0.00 | -0.00 | sell |
| NATIXIS ADVISORS, LLC | 0 | 14,968 | +14,968 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 14,083 | 14,230 | +147 | 0.10 | 0.11 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 11,878 | +11,878 | 0.00 | 0.08 | +0.08 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 14,807 | 11,644 | -3,163 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,387 | 11,187 | -5,200 | 0.00 | 0.00 | +0.00 | sell |
| PROFUND ADVISORS LLC | 14,010 | 11,112 | -2,898 | 0.02 | 0.02 | +0.00 | sell |
| Exane Asset Management | 0 | 10,100 | +10,100 | 0.00 | 0.47 | +0.47 | buy |
| ProShare Advisors LLC | 8,316 | 9,820 | +1,504 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9,350 | 9,350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 7,000 | 8,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 5,284 | 8,655 | +3,371 | 0.03 | 0.06 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 9,425 | 8,192 | -1,233 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 8,094 | +8,094 | 0.00 | 0.00 | +0.00 | buy |
| Family Management Corp | 6,953 | 8,079 | +1,126 | 0.05 | 0.08 | +0.03 | buy |
| Global Endowment Management, LP | 7,797 | 7,797 | 0 | 0.03 | 0.05 | +0.01 | hold |
| AMERICAN CENTURY COMPANIES INC | 8,673 | 7,730 | -943 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 0 | 7,540 | +7,540 | 0.00 | 0.05 | +0.05 | buy |
| FORA Capital, LLC | 0 | 6,789 | +6,789 | 0.00 | 0.05 | +0.05 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6,904 | 6,534 | -370 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 6,100 | 6,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arizona State Retirement System | 5,993 | 5,557 | -436 | 0.00 | 0.00 | +0.00 | sell |
| Valence8 US LP | 0 | 5,240 | +5,240 | 0.00 | 0.13 | +0.13 | buy |