| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 27.64 | 18.99 | -8.65 | hold |
| FMR LLC | 6,907,100 | 6,916,462 | +9,362 | 0.02 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,805,710 | 4,723,701 | +917,991 | 0.03 | 0.03 | +0.00 | buy |
| RTW INVESTMENTS, LP | 2,712,097 | 2,712,097 | 0 | 1.68 | 1.33 | -0.35 | hold |
| BlackRock, Inc. | 2,562,539 | 2,686,026 | +123,487 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,108,938 | 2,245,631 | +136,693 | 0.00 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,310,755 | 2,158,502 | -152,253 | 0.80 | 0.61 | -0.19 | sell |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 11.53 | 7.32 | -4.20 | hold |
| STATE STREET CORP | 1,259,258 | 1,655,548 | +396,290 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 958,630 | 1,521,757 | +563,127 | 1.78 | 1.79 | +0.01 | buy |
| BRAIDWELL LP | 1,478,512 | 1,438,745 | -39,767 | 2.20 | 1.70 | -0.50 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,388,149 | 1,419,132 | +30,983 | 0.02 | 0.02 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,182,148 | 1,351,989 | +169,841 | 1.93 | 1.55 | -0.37 | buy |
| Affinity Asset Advisors, LLC | 691,899 | 1,173,426 | +481,527 | 4.44 | 4.34 | -0.11 | buy |
| CITADEL ADVISORS LLC | 495,659 | 1,169,244 | +673,585 | 0.02 | 0.04 | +0.02 | buy |
| JPMORGAN CHASE & CO | 1,125,570 | 1,137,731 | +12,161 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 820,376 | 970,581 | +150,205 | 0.08 | 0.06 | -0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 782,641 | 892,203 | +109,562 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 107,157 | 799,465 | +692,308 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 760,844 | 750,529 | -10,315 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 852,531 | 730,761 | -121,770 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 608,822 | 642,316 | +33,494 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 659,186 | 599,616 | -59,570 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 642,357 | 568,084 | -74,273 | 0.46 | 0.21 | -0.25 | sell |
| Sofinnova Investments, Inc. | 76,180 | 565,417 | +489,237 | 0.23 | 1.38 | +1.15 | buy |
| Polar Capital Holdings Plc | 495,000 | 524,094 | +29,094 | 0.11 | 0.10 | -0.01 | buy |
| Novo Holdings A/S | 449,392 | 500,000 | +50,608 | 1.38 | 1.28 | -0.10 | buy |
| JANUS HENDERSON GROUP PLC | 509,321 | 485,978 | -23,343 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 474,702 | 464,963 | -9,739 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 245,133 | 430,463 | +185,330 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 425,000 | +425,000 | 0.00 | 0.77 | +0.77 | buy |
| First Turn Management, LLC | 311,490 | 402,811 | +91,321 | 2.52 | 2.40 | -0.12 | buy |
| BANK OF AMERICA CORP /DE/ | 508,987 | 393,912 | -115,075 | 0.00 | 0.00 | -0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 309,066 | 374,407 | +65,341 | 0.12 | 0.13 | +0.01 | buy |
| Opaleye Management Inc. | 0 | 363,257 | +363,257 | 0.00 | 2.04 | +2.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 266,384 | 319,903 | +53,519 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 304,000 | +304,000 | 0.00 | 5.04 | +5.04 | buy |
| Commodore Capital LP | 290,000 | 290,000 | 0 | 0.89 | 0.56 | -0.33 | hold |
| NORTHERN TRUST CORP | 264,188 | 284,483 | +20,295 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,290,464 | 235,000 | -1,055,464 | 0.09 | 0.01 | -0.08 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 254,770 | 217,213 | -37,557 | 0.01 | 0.01 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 119,246 | 215,846 | +96,600 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 200,000 | 200,000 | 0 | 0.44 | 0.31 | -0.13 | hold |
| Blackstone Inc. | 178,546 | 190,352 | +11,806 | 0.03 | 0.03 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 134,226 | +134,226 | 0.00 | 0.02 | +0.02 | buy |
| Granahan Investment Management, LLC | 131,138 | 132,400 | +1,262 | 0.23 | 0.22 | -0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 125,829 | 131,436 | +5,607 | 0.01 | 0.01 | -0.00 | buy |
| Capital World Investors | 193,895 | 127,618 | -66,277 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 0 | 126,081 | +126,081 | 0.00 | 0.03 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 75,897 | 124,051 | +48,154 | 0.08 | 0.11 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 115,694 | 122,375 | +6,681 | 0.01 | 0.01 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.09 | 0.08 | -0.00 | hold |
| Bank of New York Mellon Corp | 201,151 | 107,540 | -93,611 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 45,052 | 107,107 | +62,055 | 0.72 | 1.04 | +0.32 | buy |
| Parkman Healthcare Partners LLC | 55,404 | 105,831 | +50,427 | 0.28 | 0.46 | +0.18 | buy |
| AMERIPRISE FINANCIAL INC | 156,108 | 103,152 | -52,956 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 194,528 | 100,570 | -93,958 | 0.01 | 0.00 | -0.01 | sell |
| Exome Asset Management LLC | 0 | 94,400 | +94,400 | 0.00 | 2.48 | +2.48 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 86,512 | 93,728 | +7,216 | 0.25 | 0.24 | -0.01 | buy |
| Nuveen, LLC | 83,291 | 83,291 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 94,588 | 83,240 | -11,348 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 8,235 | 77,626 | +69,391 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 23,709 | 76,547 | +52,838 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 158,635 | 72,348 | -86,287 | 0.02 | 0.01 | -0.01 | sell |
| Rafferty Asset Management, LLC | 42,211 | 65,796 | +23,585 | 0.01 | 0.01 | +0.00 | buy |
| DIADEMA PARTNERS LP | 10,572 | 64,250 | +53,678 | 0.29 | 1.78 | +1.49 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,939 | 63,225 | -9,714 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 34,605 | 62,577 | +27,972 | 0.05 | 0.09 | +0.05 | buy |
| Woodline Partners LP | 870,208 | 57,321 | -812,887 | 0.20 | 0.01 | -0.19 | sell |
| Aberdeen Group plc | 0 | 54,760 | +54,760 | 0.00 | 0.00 | +0.00 | buy |
| Exane Asset Management | 0 | 51,543 | +51,543 | 0.00 | 0.81 | +0.81 | buy |
| Boxer Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.63 | +0.63 | buy |
| Verition Fund Management LLC | 0 | 49,523 | +49,523 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 49,216 | 47,799 | -1,417 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 21,768 | 43,673 | +21,905 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 42,600 | 43,400 | +800 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 39,332 | +39,332 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,649 | 38,223 | +34,574 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 37,535 | +37,535 | 0.00 | 0.02 | +0.02 | buy |
| COMERICA BANK | 29,469 | 35,534 | +6,065 | 0.00 | 0.01 | +0.00 | buy |
| B Group, Inc. | 35,000 | 35,000 | 0 | 1.31 | 1.33 | +0.02 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,062 | 31,163 | -23,899 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 26,866 | 29,138 | +2,272 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 27,689 | 27,663 | -26 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 0 | 26,607 | +26,607 | 0.00 | 0.04 | +0.04 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 26,241 | +26,241 | 0.00 | 0.08 | +0.08 | buy |
| Erste Asset Management GmbH | 24,000 | 24,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALPS ADVISORS INC | 24,850 | 22,506 | -2,344 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 16,853 | 21,990 | +5,137 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,386 | 21,387 | +1 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 19,238 | 19,238 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LMR Partners LLP | 0 | 18,961 | +18,961 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,555 | 18,579 | -976 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 21,632 | 18,012 | -3,620 | 0.18 | 0.14 | -0.05 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,697 | 16,689 | -22,008 | 0.00 | 0.00 | -0.00 | sell |
| Birchview Capital, LP | 16,000 | 16,000 | 0 | 0.69 | 0.48 | -0.21 | hold |
| Persistent Asset Partners Ltd | 2,425 | 14,819 | +12,394 | 0.09 | 0.43 | +0.33 | buy |
| PROFUND ADVISORS LLC | 8,981 | 14,171 | +5,190 | 0.01 | 0.02 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,070 | 13,701 | -2,369 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 68,845 | 12,860 | -55,985 | 0.00 | 0.00 | -0.00 | sell |