| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,439,798 | 5,018,880 | +579,082 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 20,570 | 489,209 | +468,639 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 373,108 | 708,400 | +335,292 | 0.03 | 0.06 | +0.03 | buy |
| BRAIDWELL LP | 491,113 | 681,101 | +189,988 | 0.33 | 0.70 | +0.37 | buy |
| STATE STREET CORP | 203,517 | 379,270 | +175,753 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 615,950 | 770,681 | +154,731 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 375,000 | 525,000 | +150,000 | 0.02 | 0.03 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 103,744 | +103,744 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 997,357 | 1,089,780 | +92,423 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 31,794 | 100,846 | +69,052 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 67,699 | +67,699 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 299,122 | 351,810 | +52,688 | 0.03 | 0.05 | +0.02 | buy |
| VANGUARD GROUP INC | 1,121,764 | 1,162,871 | +41,107 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 401,236 | 441,472 | +40,236 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 34,056 | +34,056 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 33,000 | +33,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 28,775 | +28,775 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 25,039 | +25,039 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 18,344 | +18,344 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 10,002 | 27,751 | +17,749 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 310,000 | 326,102 | +16,102 | 0.08 | 0.10 | +0.02 | buy |
| NORTHERN TRUST CORP | 161,138 | 176,773 | +15,635 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,303 | 18,309 | +14,006 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 13,786 | +13,786 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 10,640 | +10,640 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 10,381 | +10,381 | 0.00 | 0.11 | +0.11 | buy |
| JPMORGAN CHASE & CO | 13,234 | 23,064 | +9,830 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 9,481 | +9,481 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 9,231 | +9,231 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 8,153 | +8,153 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 465 | 7,826 | +7,361 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 3,180 | 10,337 | +7,157 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 6,409 | +6,409 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 59,660 | 65,683 | +6,023 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,555 | +5,555 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,205 | 8,969 | +4,764 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,586,729 | 1,591,478 | +4,749 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 151,358 | 155,765 | +4,407 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 3,984 | +3,984 | 0.00 | 0.07 | +0.07 | buy |
| CITIGROUP INC | 0 | 3,769 | +3,769 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 4,607 | 7,671 | +3,064 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 9,692 | 11,609 | +1,917 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,355 | 51,100 | +1,745 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 4,931 | 6,607 | +1,676 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,403 | 5,858 | +1,455 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,320 | 27,228 | +908 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 9,732 | 10,203 | +471 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 196 | +196 | 0.00 | 0.00 | +0.00 | buy |
| Red Tortoise LLC | 0 | 94 | +94 | 0.00 | 0.00 | +0.00 | buy |
| Glassman Wealth Services | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,820 | 15,820 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,954 | 1,954 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 1,827,901 | 1,827,901 | 0 | 1.31 | 1.14 | -0.17 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 283,683 | 283,683 | 0 | 0.24 | 0.32 | +0.09 | hold |
| GREAT POINT PARTNERS LLC | 400,000 | 400,000 | 0 | 1.60 | 1.90 | +0.30 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,977,901 | 1,977,901 | 0 | 0.83 | 0.86 | +0.03 | hold |
| ArrowMark Colorado Holdings LLC | 79,410 | 79,410 | 0 | 0.02 | 0.02 | +0.00 | hold |
| RTW INVESTMENTS, LP | 2,142,591 | 2,142,591 | 0 | 0.96 | 0.94 | -0.03 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 30,000 | 30,000 | 0 | 0.15 | 0.16 | +0.00 | hold |
| MetLife Investment Management, LLC | 10,638 | 10,638 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 19.04 | 16.28 | -2.77 | hold |
| Vivo Capital, LLC | 400,000 | 400,000 | 0 | 0.93 | 0.92 | -0.02 | hold |
| Holocene Advisors, LP | 101,202 | 101,202 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Fairmount Funds Management LLC | 2,941,176 | 2,941,176 | 0 | 7.54 | 8.68 | +1.15 | hold |
| Soleus Capital Management, L.P. | 35,000 | 35,000 | 0 | 0.08 | 0.11 | +0.03 | hold |
| Commodore Capital LP | 250,000 | 250,000 | 0 | 0.62 | 0.61 | -0.01 | hold |
| Frazier Life Sciences Management, L.P. | 400,000 | 400,000 | 0 | 0.57 | 0.60 | +0.03 | hold |
| Washington Trust Advisors, Inc. | 96 | 96 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 22,248 | 22,248 | 0 | 0.00 | 0.01 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,174 | 1,174 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 4,100 | 4,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 106 | 106 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 181 | 0 | -181 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,461 | 2,241 | -220 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 3,557 | 0 | -3,557 | 0.00 | 0.00 | -0.00 | sell |
| CAXTON CORP | 12,472 | 7,353 | -5,119 | 1.01 | 1.11 | +0.10 | sell |
| MEEDER ASSET MANAGEMENT INC | 6,632 | 0 | -6,632 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 20,341 | 13,403 | -6,938 | 0.00 | 0.00 | -0.00 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,339,275 | 1,329,064 | -10,211 | 0.37 | 0.45 | +0.08 | sell |
| Bayesian Capital Management, LP | 11,142 | 0 | -11,142 | 0.03 | 0.00 | -0.03 | sell |
| TUDOR INVESTMENT CORP ET AL | 12,515 | 0 | -12,515 | 0.00 | 0.00 | -0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 48,198 | 0 | -48,198 | 1.37 | 0.00 | -1.37 | sell |
| Deep Track Capital, LP | 2,414,373 | 2,323,456 | -90,917 | 1.99 | 2.27 | +0.28 | sell |
| JANUS HENDERSON GROUP PLC | 598,495 | 479,686 | -118,809 | 0.01 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 1,427,901 | 1,277,901 | -150,000 | 0.65 | 0.72 | +0.06 | sell |
| CITADEL ADVISORS LLC | 243,126 | 0 | -243,126 | 0.01 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 1,045,110 | 537,093 | -508,017 | 7.27 | 2.99 | -4.28 | sell |