| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 469,557 | 1,135,100 | +665,543 | 0.01 | 0.03 | 0.00 | buy |
| Paradigm Biocapital Advisors LP | 701,817 | 1,283,766 | +581,949 | 1.44 | 2.02 | +0.58 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 758,081 | 1,052,595 | +294,514 | 0.01 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 664,198 | 931,728 | +267,530 | 6.05 | 6.59 | +0.54 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,533,607 | 2,605,310 | +71,703 | 1.28 | 0.97 | -0.30 | buy |
| TWO SIGMA INVESTMENTS, LP | 199,308 | 266,482 | +67,174 | 0.03 | 0.03 | 0.00 | buy |
| Woodline Partners LP | 976,155 | 1,015,608 | +39,453 | 0.48 | 0.31 | -0.17 | buy |
| TD ASSET MANAGEMENT INC | 93,446 | 126,446 | +33,000 | 0.00 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 41,194 | 72,307 | +31,113 | 0.05 | 0.07 | +0.02 | buy |
| Rafferty Asset Management, LLC | 54,563 | 57,673 | +3,110 | 0.01 | 0.01 | -0.00 | buy |
| Granahan Investment Management, LLC | 91,757 | 92,854 | +1,097 | 0.21 | 0.18 | -0.04 | buy |
| ALPS ADVISORS INC | 35,485 | 36,410 | +925 | 0.01 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,655 | 9,547 | +892 | 0.06 | 0.04 | -0.02 | buy |
| PROFUND ADVISORS LLC | 11,112 | 11,436 | +324 | 0.02 | 0.02 | 0.00 | buy |
| RTW INVESTMENTS, LP | 2,712,096 | 2,712,097 | +1 | 2.31 | 1.86 | -0.45 | buy |
| JENNISON ASSOCIATES LLC | 312,611 | 312,391 | -220 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,138 | 1,604 | -534 | 0.06 | 0.03 | -0.03 | sell |
| Family Management Corp | 8,079 | 7,013 | -1,066 | 0.08 | 0.05 | -0.03 | sell |
| Candriam S.C.A. | 90,000 | 85,661 | -4,339 | 0.02 | 0.02 | +0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 107,694 | 95,646 | -12,048 | 0.29 | 0.25 | -0.03 | sell |
| ADAR1 Capital Management, LLC | 57,183 | 41,274 | -15,909 | 0.56 | 0.39 | -0.18 | sell |
| HighVista Strategies LLC | 61,788 | 43,190 | -18,598 | 1.25 | 0.73 | -0.52 | sell |
| BRAIDWELL LP | 1,643,226 | 1,540,362 | -102,864 | 2.74 | 2.07 | -0.67 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 311,316 | 172,711 | -138,605 | 0.17 | 0.07 | -0.10 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,961,863 | 1,569,491 | -392,372 | 1.33 | 0.95 | -0.38 | sell |
| PERCEPTIVE ADVISORS LLC | 2,015,007 | 1,047,232 | -967,775 | 2.50 | 1.31 | -1.20 | sell |