| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 26.13 | 26.40 | +0.27 | hold |
| FMR LLC | 7,502,482 | 7,499,382 | -3,100 | 0.03 | 0.02 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 4,814,400 | 4,517,363 | -297,037 | 0.05 | 0.04 | -0.01 | sell |
| BlackRock, Inc. | 2,975,917 | 3,044,958 | +69,041 | 0.00 | 0.00 | -0.00 | buy |
| RTW INVESTMENTS, LP | 2,712,096 | 2,712,097 | +1 | 2.31 | 1.86 | -0.45 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,533,607 | 2,605,310 | +71,703 | 1.28 | 0.97 | -0.30 | buy |
| VANGUARD GROUP INC | 2,127,042 | 2,097,597 | -29,445 | 0.00 | 0.00 | -0.00 | sell |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 9.76 | 9.23 | -0.53 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,961,863 | 1,569,491 | -392,372 | 1.33 | 0.95 | -0.38 | sell |
| BRAIDWELL LP | 1,643,226 | 1,540,362 | -102,864 | 2.74 | 2.07 | -0.67 | sell |
| STATE STREET CORP | 1,411,639 | 1,467,114 | +55,475 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,194,363 | 1,355,185 | +160,822 | 0.02 | 0.02 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 701,817 | 1,283,766 | +581,949 | 1.44 | 2.02 | +0.58 | buy |
| JANUS HENDERSON GROUP PLC | 469,557 | 1,135,100 | +665,543 | 0.01 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 758,081 | 1,052,595 | +294,514 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,015,007 | 1,047,232 | -967,775 | 2.54 | 1.32 | -1.22 | sell |
| Woodline Partners LP | 976,155 | 1,015,608 | +39,453 | 0.48 | 0.31 | -0.17 | buy |
| Affinity Asset Advisors, LLC | 664,198 | 931,728 | +267,530 | 6.05 | 6.59 | +0.54 | buy |
| Jefferies Financial Group Inc. | 369,197 | 887,497 | +518,300 | 0.35 | 0.45 | +0.10 | buy |
| FRANKLIN RESOURCES INC | 860,989 | 866,188 | +5,199 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 823,839 | 816,113 | -7,726 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 0 | 747,325 | +747,325 | 0.00 | 1.50 | +1.50 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 720,101 | +720,101 | 0.00 | 0.08 | +0.08 | buy |
| UBS Group AG | 51,820 | 541,286 | +489,466 | 0.00 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 365,046 | 476,760 | +111,714 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 157,457 | 408,019 | +250,562 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 306,549 | 327,292 | +20,743 | 0.00 | 0.00 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 312,611 | 312,391 | -220 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 707,268 | 302,735 | -404,533 | 0.14 | 0.04 | -0.11 | sell |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 1.59 | +1.59 | buy |
| Commodore Capital LP | 290,000 | 290,000 | 0 | 1.06 | 0.96 | -0.10 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 280,428 | 277,492 | -2,936 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 199,308 | 266,482 | +67,174 | 0.03 | 0.03 | +0.00 | buy |
| First Turn Management, LLC | 0 | 252,725 | +252,725 | 0.00 | 2.05 | +2.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 240,200 | +240,200 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 346,358 | 223,062 | -123,296 | 0.02 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 238,270 | 209,534 | -28,736 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 0 | 205,100 | +205,100 | 0.00 | 0.00 | +0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 311,316 | 172,711 | -138,605 | 0.17 | 0.07 | -0.10 | sell |
| MILLENNIUM MANAGEMENT LLC | 90,009 | 130,171 | +40,162 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 93,446 | 126,446 | +33,000 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 112,601 | 110,827 | -1,774 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.08 | 0.07 | -0.02 | hold |
| BANK OF AMERICA CORP /DE/ | 299,472 | 105,540 | -193,932 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.42 | 0.30 | -0.12 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 107,694 | 95,646 | -12,048 | 0.29 | 0.25 | -0.03 | sell |
| Granahan Investment Management, LLC | 91,757 | 92,854 | +1,097 | 0.21 | 0.18 | -0.04 | buy |
| Cubist Systematic Strategies, LLC | 83,977 | 91,213 | +7,236 | 0.07 | 0.07 | -0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67,988 | 87,953 | +19,965 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 90,000 | 85,661 | -4,339 | 0.03 | 0.02 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 0 | 85,000 | +85,000 | 0.00 | 0.51 | +0.51 | buy |
| Blackstone Inc. | 80,000 | 80,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| MARSHALL WACE, LLP | 3,675 | 75,849 | +72,174 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 72,724 | +72,724 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 41,194 | 72,307 | +31,113 | 0.05 | 0.07 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 47,200 | 71,500 | +24,300 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 70,766 | +70,766 | 0.00 | 0.02 | +0.02 | buy |
| Soleus Capital Management, L.P. | 0 | 70,000 | +70,000 | 0.00 | 0.24 | +0.24 | buy |
| Ensign Peak Advisors, Inc | 69,750 | 69,750 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 58,466 | 58,466 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 54,563 | 57,673 | +3,110 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 28,134 | 56,102 | +27,968 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 50,970 | 52,720 | +1,750 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 56,517 | 45,960 | -10,557 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 37,700 | 44,300 | +6,600 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 61,788 | 43,190 | -18,598 | 1.25 | 0.73 | -0.52 | sell |
| ADAR1 Capital Management, LLC | 57,183 | 41,274 | -15,909 | 0.56 | 0.39 | -0.18 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 41,747 | 41,106 | -641 | 0.01 | 0.01 | -0.00 | sell |
| Neo Ivy Capital Management | 0 | 38,523 | +38,523 | 0.00 | 0.35 | +0.35 | buy |
| JPMORGAN CHASE & CO | 29,555 | 37,255 | +7,700 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 35,485 | 36,410 | +925 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 19,043 | 36,344 | +17,301 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 32,241 | 32,261 | +20 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 21,030 | 31,739 | +10,709 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 51,530 | 31,288 | -20,242 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 20,870 | 25,873 | +5,003 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 24,535 | 24,535 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Erste Asset Management GmbH | 0 | 24,000 | +24,000 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,904 | 23,835 | +931 | 0.00 | 0.00 | -0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 23,400 | +23,400 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 21,115 | 22,960 | +1,845 | 0.01 | 0.01 | -0.00 | buy |
| Point72 (DIFC) Ltd | 19,207 | 22,191 | +2,984 | 0.09 | 0.09 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,609 | 22,178 | +2,569 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 132,166 | 21,256 | -110,910 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 20,867 | +20,867 | 0.00 | 0.02 | +0.02 | buy |
| COMERICA BANK | 28,058 | 20,540 | -7,518 | 0.01 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 19,477 | +19,477 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 20,261 | 18,839 | -1,422 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 98,290 | 17,705 | -80,585 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 5,100 | 16,934 | +11,834 | 0.00 | 0.01 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 14,968 | 14,778 | -190 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,192 | 13,393 | +5,201 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 9,820 | 12,805 | +2,985 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,187 | 12,187 | +1,000 | 0.00 | 0.00 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 11,644 | 11,644 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PROFUND ADVISORS LLC | 11,112 | 11,436 | +324 | 0.02 | 0.02 | -0.01 | buy |
| SG Americas Securities, LLC | 8,094 | 9,890 | +1,796 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 49,662 | 9,813 | -39,849 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,655 | 9,547 | +892 | 0.06 | 0.04 | -0.02 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9,350 | 9,350 | 0 | 0.00 | 0.00 | -0.00 | hold |