| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 8,493,321 | 8,493,321 | 0 | 18.99 | 31.67 | +12.67 | hold |
| FMR LLC | 6,916,462 | 8,225,038 | +1,308,576 | 0.01 | 0.03 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,723,701 | 4,746,585 | +22,884 | 0.03 | 0.06 | +0.03 | buy |
| BlackRock, Inc. | 2,686,026 | 3,783,994 | +1,097,968 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,245,631 | 2,857,824 | +612,193 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,441 | 2,732,456 | +2,731,015 | 0.00 | 0.13 | +0.13 | buy |
| RTW INVESTMENTS, LP | 2,712,097 | 2,712,097 | 0 | 1.33 | 2.05 | +0.72 | hold |
| PERCEPTIVE ADVISORS LLC | 1,351,989 | 2,330,651 | +978,662 | 1.55 | 3.22 | +1.67 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,158,502 | 2,183,704 | +25,202 | 0.61 | 1.12 | +0.51 | buy |
| JANUS HENDERSON GROUP PLC | 485,978 | 2,062,604 | +1,576,626 | 0.01 | 0.07 | +0.06 | buy |
| Fairmount Funds Management LLC | 2,048,647 | 2,048,647 | 0 | 7.32 | 11.77 | +4.45 | hold |
| STATE STREET CORP | 1,655,548 | 1,690,186 | +34,638 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,137,731 | 1,373,066 | +235,335 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 750,529 | 1,237,135 | +486,606 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 1,173,426 | 1,234,926 | +61,500 | 4.34 | 6.70 | +2.36 | buy |
| Paradigm Biocapital Advisors LP | 1,521,757 | 1,123,243 | -398,514 | 1.79 | 2.27 | +0.48 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,419,132 | 1,093,657 | -325,475 | 0.02 | 0.03 | +0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 892,203 | 1,059,085 | +166,882 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 799,465 | 974,826 | +175,361 | 0.01 | 0.01 | +0.01 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 970,581 | 890,665 | -79,916 | 0.06 | 0.10 | +0.04 | sell |
| MORGAN STANLEY | 464,963 | 890,264 | +425,301 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 393,912 | 793,695 | +399,783 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,169,244 | 766,981 | -402,263 | 0.04 | 0.04 | +0.00 | sell |
| JENNISON ASSOCIATES LLC | 0 | 578,627 | +578,627 | 0.00 | 0.03 | +0.03 | buy |
| BRAIDWELL LP | 1,438,745 | 575,067 | -863,678 | 1.70 | 1.39 | -0.31 | sell |
| Novo Holdings A/S | 500,000 | 570,000 | +70,000 | 1.28 | 3.34 | +2.06 | buy |
| GOLDMAN SACHS GROUP INC | 599,616 | 565,410 | -34,206 | 0.00 | 0.01 | +0.00 | sell |
| Vestal Point Capital, LP | 425,000 | 550,000 | +125,000 | 0.77 | 1.52 | +0.76 | buy |
| Sofinnova Investments, Inc. | 565,417 | 534,845 | -30,572 | 1.38 | 1.74 | +0.36 | sell |
| Polar Capital Holdings Plc | 524,094 | 503,539 | -20,555 | 0.10 | 0.17 | +0.07 | sell |
| Avoro Capital Advisors LLC | 0 | 500,000 | +500,000 | 0.00 | 0.37 | +0.37 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 374,407 | 480,453 | +106,046 | 0.13 | 0.38 | +0.25 | buy |
| First Turn Management, LLC | 402,811 | 474,839 | +72,028 | 2.40 | 4.10 | +1.69 | buy |
| FRANKLIN RESOURCES INC | 730,761 | 451,002 | -279,759 | 0.01 | 0.01 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 436,015 | +436,015 | 0.00 | 0.51 | +0.51 | buy |
| Opaleye Management Inc. | 363,257 | 388,257 | +25,000 | 2.04 | 3.87 | +1.83 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 319,903 | 381,362 | +61,459 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 304,000 | 374,000 | +70,000 | 5.04 | 9.15 | +4.11 | buy |
| NORTHERN TRUST CORP | 284,483 | 327,376 | +42,893 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 312,883 | +312,883 | 0.00 | 0.02 | +0.02 | buy |
| First Light Asset Management, LLC | 0 | 284,991 | +284,991 | 0.00 | 1.64 | +1.64 | buy |
| LOOMIS SAYLES & CO L P | 0 | 255,439 | +255,439 | 0.00 | 0.02 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 235,000 | 240,000 | +5,000 | 0.01 | 0.03 | +0.01 | buy |
| Woodline Partners LP | 57,321 | 210,466 | +153,145 | 0.01 | 0.06 | +0.05 | buy |
| Candriam S.C.A. | 126,081 | 191,318 | +65,237 | 0.03 | 0.07 | +0.05 | buy |
| MILLENNIUM MANAGEMENT LLC | 430,463 | 140,727 | -289,736 | 0.01 | 0.01 | -0.01 | sell |
| BARCLAYS PLC | 642,316 | 133,193 | -509,123 | 0.01 | 0.00 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 105,831 | 130,069 | +24,238 | 0.46 | 0.93 | +0.47 | buy |
| TD ASSET MANAGEMENT INC | 83,240 | 129,290 | +46,050 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 0 | 127,931 | +127,931 | 0.00 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 131,436 | 127,629 | -3,807 | 0.01 | 0.02 | +0.01 | sell |
| Capital World Investors | 127,618 | 127,618 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 124,051 | 124,979 | +928 | 0.11 | 0.20 | +0.09 | buy |
| AMERIPRISE FINANCIAL INC | 103,152 | 122,900 | +19,748 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 83,291 | 121,050 | +37,759 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 107,540 | 118,084 | +10,544 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 112,924 | +112,924 | 0.00 | 0.62 | +0.62 | buy |
| ArrowMark Colorado Holdings LLC | 109,410 | 109,410 | 0 | 0.08 | 0.18 | +0.10 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 217,213 | 108,267 | -108,946 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 122,375 | 105,241 | -17,134 | 0.01 | 0.01 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 215,846 | 105,000 | -110,846 | 0.01 | 0.01 | -0.00 | sell |
| Neuberger Berman Group LLC | 0 | 99,648 | +99,648 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 132,400 | 94,720 | -37,680 | 0.22 | 0.31 | +0.09 | sell |
| HighVista Strategies LLC | 107,107 | 89,229 | -17,878 | 1.04 | 1.73 | +0.69 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,225 | 80,832 | +17,607 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 80,574 | +80,574 | 0.00 | 1.04 | +1.04 | buy |
| DEUTSCHE BANK AG\ | 76,547 | 79,361 | +2,814 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 76,898 | +76,898 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 134,226 | 73,262 | -60,964 | 0.02 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 29,138 | 70,687 | +41,549 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 50,000 | 70,000 | +20,000 | 0.63 | 1.16 | +0.52 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 93,728 | 69,212 | -24,516 | 0.24 | 1.21 | +0.97 | sell |
| D. E. Shaw & Co., Inc. | 100,570 | 63,250 | -37,320 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 43,400 | 62,900 | +19,500 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 62,799 | +62,799 | 0.00 | 0.13 | +0.13 | buy |
| PRUDENTIAL FINANCIAL INC | 12,860 | 54,300 | +41,440 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 190,352 | 51,827 | -138,525 | 0.03 | 0.02 | -0.02 | sell |
| MARSHALL WACE, LLP | 7,027 | 50,744 | +43,717 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.29 | +0.29 | buy |
| Russell Investments Group, Ltd. | 43,673 | 49,999 | +6,326 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 31,163 | 49,805 | +18,642 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 65,796 | 48,619 | -17,177 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 47,799 | 45,971 | -1,828 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 22,506 | 44,922 | +22,416 | 0.00 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 21,990 | 42,499 | +20,509 | 0.00 | 0.00 | +0.00 | buy |
| BANQUE PICTET & CIE SA | 0 | 41,800 | +41,800 | 0.00 | 0.03 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 202 | 39,846 | +39,644 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 54,760 | 36,103 | -18,657 | 0.00 | 0.00 | +0.00 | sell |
| COMERICA BANK | 35,534 | 35,872 | +338 | 0.01 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 33,264 | +33,264 | 0.00 | 0.14 | +0.14 | buy |
| Legal & General Group Plc | 27,663 | 32,856 | +5,193 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,387 | 30,758 | +9,371 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 30,039 | +30,039 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 29,145 | +29,145 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 24,000 | 24,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,887 | 22,484 | +12,597 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,238 | 21,311 | +2,073 | 0.00 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 26,607 | 20,972 | -5,635 | 0.04 | 0.05 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 18,579 | 20,709 | +2,130 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,095 | 20,313 | +12,218 | 0.00 | 0.00 | +0.00 | buy |