| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,441 | 2,732,456 | +2,731,015 | 0.00 | 0.13 | +0.13 | buy |
| PERCEPTIVE ADVISORS LLC | 1,351,989 | 2,330,651 | +978,662 | 1.55 | 3.14 | +1.58 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 750,529 | 1,237,135 | +486,606 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 425,000 | 550,000 | +125,000 | 0.77 | 1.52 | +0.76 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 215,846 | 105,000 | +110,846 | 0.01 | 0.01 | -0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 374,407 | 480,453 | +106,046 | 0.13 | 0.38 | +0.25 | buy |
| First Turn Management, LLC | 402,811 | 474,839 | +72,028 | 2.40 | 4.10 | +1.69 | buy |
| Novo Holdings A/S | 500,000 | 570,000 | +70,000 | 1.28 | 3.34 | +2.06 | buy |
| GREAT POINT PARTNERS LLC | 304,000 | 374,000 | +70,000 | 4.98 | 9.15 | +4.17 | buy |
| Candriam S.C.A. | 126,081 | 191,318 | +65,237 | 0.03 | 0.07 | +0.05 | buy |
| Affinity Asset Advisors, LLC | 1,173,426 | 1,234,926 | +61,500 | 4.34 | 6.70 | +2.36 | buy |
| TD ASSET MANAGEMENT INC | 83,240 | 129,290 | +46,050 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,158,502 | 2,183,704 | +25,202 | 0.61 | 1.12 | +0.51 | buy |
| Opaleye Management Inc. | 363,257 | 388,257 | +25,000 | 2.04 | 3.87 | +1.83 | buy |
| Parkman Healthcare Partners LLC | 105,831 | 130,069 | +24,238 | 0.46 | 0.93 | +0.47 | buy |
| ALPS ADVISORS INC | 22,506 | 44,922 | +22,416 | 0.00 | 0.02 | 0.00 | buy |
| Boxer Capital Management, LLC | 50,000 | 70,000 | +20,000 | 0.63 | 1.16 | +0.52 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 235,000 | 240,000 | +5,000 | 0.01 | 0.03 | +0.01 | buy |
| PROFUND ADVISORS LLC | 14,171 | 18,276 | +4,105 | 0.02 | 0.04 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 124,051 | 124,979 | +928 | 0.11 | 0.20 | +0.09 | buy |
| China Universal Asset Management Co., Ltd. | 8,082 | 8,935 | +853 | 0.03 | 0.05 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 2,718 | 3,451 | +733 | 0.03 | 0.07 | +0.04 | buy |
| GF FUND MANAGEMENT CO. LTD. | 992 | 1,077 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 17 | 18 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 36 | 24 | -12 | 0.00 | 0.00 | -0.00 | sell |
| ANTIPODES PARTNERS Ltd | 843 | 723 | -120 | 0.00 | 0.00 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 18,012 | 17,164 | -848 | 0.14 | 0.24 | +0.11 | sell |
| SummitTX Capital, L.P. | 26,607 | 20,972 | -5,635 | 0.04 | 0.05 | +0.00 | sell |
| Persistent Asset Partners Ltd | 14,819 | 2,445 | -12,374 | 0.43 | 0.09 | -0.34 | sell |
| B Group, Inc. | 35,000 | 20,000 | -15,000 | 1.33 | 1.12 | -0.21 | sell |
| Rafferty Asset Management, LLC | 65,796 | 48,619 | -17,177 | 0.01 | 0.01 | +0.00 | sell |
| HighVista Strategies LLC | 107,107 | 89,229 | -17,878 | 1.04 | 1.73 | +0.69 | sell |
| Aberdeen Group plc | 54,760 | 36,103 | -18,657 | 0.00 | 0.00 | +0.00 | sell |
| Polar Capital Holdings Plc | 524,094 | 503,539 | -20,555 | 0.10 | 0.17 | +0.07 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 93,728 | 69,212 | -24,516 | 0.24 | 1.21 | +0.97 | sell |
| Sofinnova Investments, Inc. | 565,417 | 534,845 | -30,572 | 1.23 | 1.74 | +0.51 | sell |
| Granahan Investment Management, LLC | 132,400 | 94,720 | -37,680 | 0.22 | 0.31 | +0.09 | sell |
| Exane Asset Management | 51,543 | 52 | -51,491 | 0.81 | 0.00 | -0.81 | sell |
| J. Goldman & Co LP | 62,577 | 3,466 | -59,111 | 0.06 | 0.01 | -0.06 | sell |
| Paradigm Biocapital Advisors LP | 1,521,757 | 1,123,243 | -398,514 | 1.79 | 2.27 | +0.48 | sell |
| BRAIDWELL LP | 1,438,745 | 575,067 | -863,678 | 1.70 | 1.39 | -0.31 | sell |