| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,452,024 | 4,396,124 | +1,944,100 | 1.90 | 1.04 | -0.87 | buy |
| TRV GP VI, LLC | 3,152,456 | 4,211,659 | +1,059,203 | 61.75 | 58.10 | -3.65 | buy |
| Checkpoint Capital L.P. | 0 | 824,878 | +824,878 | 0.00 | 2.62 | +2.62 | buy |
| ADAR1 Capital Management, LLC | 0 | 720,848 | +720,848 | 0.00 | 0.80 | +0.80 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,589,553 | 3,122,608 | +533,055 | 0.49 | 0.17 | -0.32 | buy |
| Sio Capital Management, LLC | 271,687 | 788,670 | +516,983 | 1.75 | 1.38 | -0.37 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 436,564 | +436,564 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 2,768,520 | 3,149,128 | +380,608 | 8.70 | 3.25 | -5.45 | buy |
| Woodline Partners LP | 300,000 | 582,585 | +282,585 | 0.05 | 0.02 | -0.02 | buy |
| Avoro Capital Advisors LLC | 1,110,000 | 1,337,500 | +227,500 | 0.36 | 0.12 | -0.24 | buy |
| UBS Group AG | 108,453 | 239,930 | +131,477 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 675,409 | 751,353 | +75,944 | 1.17 | 0.34 | -0.83 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 74,841 | +74,841 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 272,776 | 344,604 | +71,828 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 68,084 | +68,084 | 0.00 | 0.38 | +0.38 | buy |
| Rangeley Capital, LLC | 0 | 52,950 | +52,950 | 0.00 | 0.35 | +0.35 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,370 | 44,362 | +42,992 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 37,350 | +37,350 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 30,100 | +30,100 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 380,577 | 409,640 | +29,063 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 14,633 | 38,055 | +23,422 | 0.00 | 0.00 | -0.00 | buy |
| STONERIDGE INVESTMENT PARTNERS LLC | 0 | 18,477 | +18,477 | 0.00 | 0.09 | +0.09 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 18,299 | +18,299 | 0.00 | 0.01 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 0 | 10,954 | +10,954 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 147,776 | 158,040 | +10,264 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 985,032 | 995,044 | +10,012 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 8,400 | +8,400 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 10,419 | 15,968 | +5,549 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 3,555 | +3,555 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 19,995 | 23,318 | +3,323 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,400 | 2,900 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,093 | 1,788 | +695 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,519 | 10,987 | +468 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 15 | 434 | +419 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 38,093 | 38,376 | +283 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 0 | 282 | +282 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,651 | 10,869 | +218 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,154 | 12,202 | +48 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 30 | +30 | 0.00 | 0.00 | 0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 6 | +6 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,944 | 1,944 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | 6,995,858 | 0 | 2.13 | 0.68 | -1.46 | hold |
| Alyeska Investment Group, L.P. | 35,000 | 35,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Casdin Capital, LLC | 553,268 | 553,268 | 0 | 0.85 | 0.26 | -0.59 | hold |
| Logos Global Management LP | 134,202 | 134,202 | 0 | 0.36 | 0.14 | -0.22 | hold |
| Deep Track Capital, LP | 1,912,929 | 1,912,929 | 0 | 1.64 | 0.36 | -1.28 | hold |
| Catalio Capital Management, LP | 1,024,245 | 1,024,245 | 0 | 5.13 | 1.47 | -3.66 | hold |
| TRV GP V, LLC | 6,215,591 | 6,215,591 | 0 | 48.42 | 28.77 | -19.65 | hold |
| Siren, L.L.C. | 2,202,514 | 2,202,514 | 0 | 2.23 | 0.72 | -1.51 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 102,749 | 102,749 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,840 | 1,840 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 3,400 | 3,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 634 | 634 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 266 | 157 | -109 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 9,236 | 9,102 | -134 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,251 | 1,149 | -1,102 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,680 | 0 | -2,680 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 28,785 | 22,733 | -6,052 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 8,095 | 0 | -8,095 | 0.00 | 0.00 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 11,555 | 0 | -11,555 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 12,118 | 0 | -12,118 | 0.01 | 0.00 | -0.01 | sell |
| M&T BANK CORP | 16,394 | 0 | -16,394 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 20,204 | 0 | -20,204 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 139,616 | 118,451 | -21,165 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,095 | 0 | -22,095 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 22,695 | 0 | -22,695 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 26,208 | 0 | -26,208 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 38,015 | 8,786 | -29,229 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 69,460 | 0 | -69,460 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 78,744 | 0 | -78,744 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 147,886 | 0 | -147,886 | 0.05 | 0.00 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 1,674,357 | 1,449,399 | -224,958 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | 0 | -300,000 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 404,882 | 0 | -404,882 | 0.01 | 0.00 | -0.01 | sell |
| BlackRock, Inc. | 1,677,135 | 1,258,313 | -418,822 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 518,588 | 22,957 | -495,631 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 560,000 | 0 | -560,000 | 0.70 | 0.00 | -0.70 | sell |
| PERCEPTIVE ADVISORS LLC | 750,000 | 0 | -750,000 | 0.48 | 0.00 | -0.48 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 861,814 | 0 | -861,814 | 0.38 | 0.00 | -0.38 | sell |
| FMR LLC | 1,002,958 | 49,778 | -953,180 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 1,096,302 | 0 | -1,096,302 | 0.01 | 0.00 | -0.01 | sell |