| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | 6,995,858 | 0 | 2.00 | 1.78 | -0.22 | hold |
| TRV GP V, LLC | 6,215,591 | 6,215,591 | 0 | 40.38 | 37.25 | -3.13 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,809,470 | 4,395,572 | -413,898 | 0.91 | 0.78 | -0.13 | sell |
| TRV GP VI, LLC | 4,211,659 | 4,211,659 | 0 | 79.05 | 74.64 | -4.41 | hold |
| Samsara BioCapital, LLC | 3,149,128 | 3,149,128 | 0 | 9.06 | 7.35 | -1.70 | hold |
| GOLDMAN SACHS GROUP INC | 2,715,129 | 2,906,427 | +191,298 | 0.01 | 0.01 | -0.00 | buy |
| Siren, L.L.C. | 2,000,000 | 2,000,000 | 0 | 1.66 | 1.33 | -0.33 | hold |
| BlackRock, Inc. | 1,801,328 | 1,822,174 | +20,846 | 0.00 | 0.00 | -0.00 | buy |
| BVF INC/IL | 1,720,782 | 1,353,249 | -367,533 | 1.61 | 1.04 | -0.58 | sell |
| Avoro Capital Advisors LLC | 1,337,500 | 1,337,500 | 0 | 0.37 | 0.32 | -0.05 | hold |
| ADAR1 Capital Management, LLC | 1,157,611 | 1,089,818 | -67,793 | 2.41 | 1.57 | -0.84 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 546,100 | 1,048,834 | +502,734 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 890,754 | +890,754 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 620,811 | 732,860 | +112,049 | 1.32 | 1.58 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 572,734 | 645,146 | +72,412 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 540,028 | 631,447 | +91,419 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 553,268 | 553,268 | 0 | 0.96 | 1.01 | +0.05 | hold |
| VR Adviser, LLC | 610,808 | 506,056 | -104,752 | 0.84 | 0.45 | -0.39 | sell |
| Catalio Capital Management, LP | 294,360 | 294,360 | 0 | 1.45 | 1.48 | +0.03 | hold |
| Soleus Capital Management, L.P. | 383,368 | 275,000 | -108,368 | 0.45 | 0.27 | -0.19 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 3,571 | 236,679 | +233,108 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | 223,995 | +1,293 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 187,241 | 181,580 | -5,661 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 154,196 | 164,530 | +10,334 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 107,463 | 124,101 | +16,638 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 68,817 | 116,979 | +48,162 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 103,985 | 110,530 | +6,545 | 0.00 | 0.00 | -0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 105,000 | +105,000 | 0.00 | 0.55 | +0.55 | buy |
| Checkpoint Capital L.P. | 0 | 100,300 | +100,300 | 0.00 | 0.86 | +0.86 | buy |
| FEDERATED HERMES, INC. | 78,905 | 89,301 | +10,396 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 68,338 | 84,674 | +16,336 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 162,014 | 82,868 | -79,146 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 92,809 | 75,367 | -17,442 | 0.00 | 0.00 | -0.00 | sell |
| Longaeva Partners L.P. | 49,902 | 74,567 | +24,665 | 0.17 | 0.09 | -0.08 | buy |
| AMERICAN CENTURY COMPANIES INC | 50,689 | 61,290 | +10,601 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 55,332 | 58,709 | +3,377 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 8,399 | 53,011 | +44,612 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 0 | 47,506 | +47,506 | 0.00 | 0.06 | +0.06 | buy |
| MARSHALL WACE, LLP | 226,901 | 39,840 | -187,061 | 0.01 | 0.00 | -0.01 | sell |
| Rangeley Capital, LLC | 65,800 | 39,800 | -26,000 | 1.58 | 1.03 | -0.55 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 37,700 | +37,700 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 23,315 | 36,723 | +13,408 | 0.02 | 0.02 | -0.00 | buy |
| Trexquant Investment LP | 44,005 | 35,301 | -8,704 | 0.01 | 0.01 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 35,000 | 35,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 30,877 | 30,978 | +101 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 25,798 | 29,176 | +3,378 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 61,370 | 28,436 | -32,934 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,443 | 28,076 | +2,633 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,419 | 26,604 | +185 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 37,594 | 25,973 | -11,621 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 25,770 | +25,770 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 24,000 | +24,000 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 23,548 | 23,548 | 0 | 0.04 | 0.03 | -0.01 | hold |
| FMR LLC | 3,307 | 23,446 | +20,139 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 38,147 | 22,714 | -15,433 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 34,944 | 21,035 | -13,909 | 0.02 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 19,600 | 19,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 14,847 | 18,083 | +3,236 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 14,600 | 17,200 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,879 | 16,843 | +1,964 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 16,528 | +16,528 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 7,826 | 15,375 | +7,549 | 0.00 | 0.00 | +0.00 | buy |
| Numerai GP LLC | 45,866 | 15,082 | -30,784 | 0.15 | 0.04 | -0.12 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 18,550 | 14,214 | -4,336 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 13,685 | 13,685 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 0 | 12,776 | +12,776 | 0.00 | 0.09 | +0.09 | buy |
| OSAIC HOLDINGS, INC. | 12,693 | 12,698 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 0 | 12,343 | +12,343 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,296 | 11,946 | +1,650 | 0.02 | 0.02 | -0.00 | buy |
| Man Group plc | 0 | 11,858 | +11,858 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 15,310 | 11,515 | -3,795 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 10,457 | 10,719 | +262 | 0.08 | 0.07 | -0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 10,382 | +10,382 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,934 | 10,021 | +87 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,529 | 9,869 | -16,660 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 9,561 | 9,195 | -366 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 0 | 8,842 | +8,842 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 1,945 | 5,735 | +3,790 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,600 | 5,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 5,449 | 5,361 | -88 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 5,175 | 5,175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 10,594 | 3,374 | -7,220 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,176 | 2,335 | +159 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 1,941 | 2,260 | +319 | 0.03 | 0.04 | +0.01 | buy |
| Ameritas Investment Partners, Inc. | 1,944 | 1,944 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,316 | 1,157 | -159 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 916 | 1,110 | +194 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 878 | 1,006 | +128 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 989 | 966 | -23 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 888 | 894 | +6 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 341 | 841 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,156 | 717 | -1,439 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 1,232 | 712 | -520 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 508 | +508 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 322 | 322 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 261 | 261 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 0 | 204 | +204 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 202 | +202 | 0.00 | 0.00 | +0.00 | buy |