| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DRIEHAUS CAPITAL MANAGEMENT LLC | 3,122,608 | 4,680,431 | +1,557,823 | 0.17 | 0.40 | +0.22 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 541,450 | +541,450 | 0.00 | 0.21 | +0.21 | buy |
| VR Adviser, LLC | 0 | 540,453 | +540,453 | 0.00 | 0.43 | +0.43 | buy |
| VANGUARD GROUP INC | 995,044 | 1,414,363 | +419,319 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 166,506 | +166,506 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,258,313 | 1,390,800 | +132,487 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 720,848 | 847,227 | +126,379 | 0.80 | 1.45 | +0.65 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 102,749 | 222,702 | +119,953 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 99,213 | +99,213 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 409,640 | 487,956 | +78,316 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 118,451 | 154,781 | +36,330 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 23,961 | 57,971 | +34,010 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 28,700 | +28,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 344,604 | 369,992 | +25,388 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 24,142 | +24,142 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 30 | 23,525 | +23,495 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 16,761 | +16,761 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 13,685 | +13,685 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 22,733 | 35,706 | +12,973 | 0.00 | 0.00 | +0.00 | buy |
| CW Advisors, LLC | 0 | 12,589 | +12,589 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 12,200 | +12,200 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 10,737 | +10,737 | 0.00 | 0.00 | +0.00 | buy |
| PharVision Advisers, LLC | 0 | 10,152 | +10,152 | 0.00 | 0.15 | +0.15 | buy |
| Quadrature Capital Ltd | 0 | 10,125 | +10,125 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 38,376 | 48,489 | +10,113 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 52,950 | 58,605 | +5,655 | 0.35 | 0.78 | +0.43 | buy |
| RHUMBLINE ADVISERS | 23,318 | 28,572 | +5,254 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 18,299 | 23,527 | +5,228 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 10,869 | 14,717 | +3,848 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 3,601 | +3,601 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 74,841 | 77,642 | +2,801 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 6 | 2,324 | +2,318 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,957 | 24,902 | +1,945 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 8,786 | 10,101 | +1,315 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,149 | 2,210 | +1,061 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 966 | +966 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 789 | +789 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,987 | 11,697 | +710 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 605 | +605 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 282 | 872 | +590 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,788 | 2,225 | +437 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 157 | 577 | +420 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 265 | +265 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 212 | +212 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 434 | 577 | +143 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,840 | 1,945 | +105 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 71 | +71 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 134 | 143 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,944 | 1,944 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 4,396,124 | 4,396,124 | 0 | 1.04 | 1.66 | +0.62 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | 6,995,858 | 0 | 0.68 | 1.25 | +0.57 | hold |
| Alyeska Investment Group, L.P. | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 553,268 | 553,268 | 0 | 0.26 | 0.53 | +0.27 | hold |
| Samsara BioCapital, LLC | 3,149,128 | 3,149,128 | 0 | 3.25 | 6.81 | +3.56 | hold |
| TRV GP VI, LLC | 4,211,659 | 4,211,659 | 0 | 58.10 | 69.32 | +11.22 | hold |
| TRV GP V, LLC | 6,215,591 | 6,215,591 | 0 | 28.77 | 39.66 | +10.89 | hold |
| Siren, L.L.C. | 2,202,514 | 2,202,514 | 0 | 0.72 | 1.20 | +0.49 | hold |
| Police & Firemen's Retirement System of New Jersey | 3,555 | 3,555 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,900 | 2,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 3,400 | 3,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 634 | 634 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 12,202 | 11,833 | -369 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 158,040 | 154,344 | -3,696 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 15,968 | 12,123 | -3,845 | 0.00 | 0.00 | +0.00 | sell |
| KLP KAPITALFORVALTNING AS | 8,400 | 0 | -8,400 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 9,102 | 0 | -9,102 | 0.00 | 0.00 | -0.00 | sell |
| Chicago Partners Investment Group LLC | 10,954 | 0 | -10,954 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 37,350 | 22,330 | -15,020 | 0.01 | 0.01 | -0.00 | sell |
| STONERIDGE INVESTMENT PARTNERS LLC | 18,477 | 0 | -18,477 | 0.09 | 0.00 | -0.09 | sell |
| Logos Global Management LP | 134,202 | 109,202 | -25,000 | 0.14 | 0.15 | +0.02 | sell |
| Swiss National Bank | 30,100 | 0 | -30,100 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 38,055 | 7,173 | -30,882 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,449,399 | 1,416,314 | -33,085 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,362 | 1,370 | -42,992 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 49,778 | 2,485 | -47,293 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 68,084 | 0 | -68,084 | 0.38 | 0.00 | -0.38 | sell |
| Avoro Capital Advisors LLC | 1,337,500 | 1,237,500 | -100,000 | 0.12 | 0.23 | +0.11 | sell |
| UBS Group AG | 239,930 | 72,335 | -167,595 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 788,670 | 584,435 | -204,235 | 1.38 | 2.48 | +1.10 | sell |
| Checkpoint Capital L.P. | 824,878 | 586,473 | -238,405 | 2.62 | 2.89 | +0.27 | sell |
| Woodline Partners LP | 582,585 | 282,585 | -300,000 | 0.02 | 0.02 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 436,564 | 51,944 | -384,620 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 751,353 | 75,456 | -675,897 | 0.34 | 0.06 | -0.29 | sell |
| Catalio Capital Management, LP | 1,024,245 | 294,360 | -729,885 | 1.47 | 0.65 | -0.82 | sell |
| Deep Track Capital, LP | 1,912,929 | 121,716 | -1,791,213 | 0.36 | 0.04 | -0.32 | sell |