| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | 6,995,858 | 0 | 1.78 | 2.04 | +0.25 | hold |
| TRV GP V, LLC | 6,215,591 | 6,215,591 | 0 | 37.25 | 41.78 | +4.53 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,395,572 | 4,433,058 | +37,486 | 0.78 | 0.86 | +0.08 | buy |
| TRV GP VI, LLC | 4,211,659 | 4,211,659 | 0 | 74.64 | 60.72 | -13.91 | hold |
| Samsara BioCapital, LLC | 3,149,128 | 3,149,128 | 0 | 7.35 | 8.66 | +1.31 | hold |
| GOLDMAN SACHS GROUP INC | 2,906,427 | 3,062,766 | +156,339 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 1,822,174 | 1,932,088 | +109,914 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 2,000,000 | 1,900,000 | -100,000 | 1.33 | 1.29 | -0.04 | sell |
| Avoro Capital Advisors LLC | 1,337,500 | 1,337,500 | 0 | 0.32 | 0.40 | +0.09 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 1,048,834 | 1,167,382 | +118,548 | 0.02 | 0.02 | +0.00 | buy |
| First Light Asset Management, LLC | 732,860 | 963,260 | +230,400 | 1.58 | 1.96 | +0.38 | buy |
| ADAR1 Capital Management, LLC | 1,089,818 | 940,747 | -149,071 | 1.57 | 1.48 | -0.09 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 645,146 | 679,163 | +34,017 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 631,447 | 652,630 | +21,183 | 0.00 | 0.00 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 624,752 | +624,752 | 0.00 | 0.03 | +0.03 | buy |
| Casdin Capital, LLC | 553,268 | 553,268 | 0 | 1.01 | 0.93 | -0.08 | hold |
| Catalio Capital Management, LP | 294,360 | 536,152 | +241,792 | 1.48 | 3.37 | +1.90 | buy |
| ALGERT GLOBAL LLC | 21,035 | 397,487 | +376,452 | 0.01 | 0.16 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 236,679 | 350,442 | +113,763 | 0.01 | 0.02 | +0.01 | buy |
| Longaeva Partners L.P. | 74,567 | 298,171 | +223,604 | 0.09 | 0.29 | +0.20 | buy |
| Soleus Capital Management, L.P. | 275,000 | 275,000 | 0 | 0.27 | 0.32 | +0.05 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 223,995 | 222,702 | -1,293 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 75,367 | 220,885 | +145,518 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 164,530 | 201,131 | +36,601 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 187,041 | +187,041 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181,580 | 187,041 | +5,461 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 185,535 | +185,535 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 110,530 | 134,377 | +23,847 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 116,979 | 89,874 | -27,105 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 89,301 | 86,753 | -2,548 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 84,674 | 85,301 | +627 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 75,425 | +75,425 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 75,309 | +75,309 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 74,649 | +74,649 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 28,436 | 68,180 | +39,744 | 0.00 | 0.01 | +0.01 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 105,000 | 63,000 | -42,000 | 0.55 | 0.49 | -0.06 | sell |
| AMERICAN CENTURY COMPANIES INC | 61,290 | 60,973 | -317 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 58,709 | 56,176 | -2,533 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 36,723 | 54,489 | +17,766 | 0.02 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 124,101 | 50,562 | -73,539 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,714 | 49,821 | +27,107 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 29,176 | 48,229 | +19,053 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 47,506 | 47,506 | 0 | 0.06 | 0.08 | +0.03 | hold |
| D. E. Shaw & Co., Inc. | 0 | 46,483 | +46,483 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 45,552 | +45,552 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 44,435 | +44,435 | 0.00 | 0.03 | +0.03 | buy |
| HRT FINANCIAL LP | 0 | 42,022 | +42,022 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 37,700 | 41,419 | +3,719 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 11,515 | 39,817 | +28,302 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 38,006 | +38,006 | 0.00 | 0.04 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 25,973 | 35,875 | +9,902 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28,076 | 35,323 | +7,247 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 19,600 | 29,900 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 29,452 | +29,452 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 29,337 | +29,337 | 0.00 | 0.22 | +0.22 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 28,966 | +28,966 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 26,604 | 27,636 | +1,032 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 35,301 | 25,645 | -9,656 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 82,868 | 24,094 | -58,774 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 23,548 | 23,548 | 0 | 0.03 | 0.03 | +0.00 | hold |
| FMR LLC | 23,446 | 23,240 | -206 | 0.00 | 0.00 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 22,038 | +22,038 | 0.00 | 0.12 | +0.12 | buy |
| DEUTSCHE BANK AG\ | 16,843 | 21,873 | +5,030 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 18,083 | 21,219 | +3,136 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 17,200 | 21,000 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 30,978 | 20,996 | -9,982 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 20,958 | +20,958 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 53,011 | 20,200 | -32,811 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 22,100 | 19,800 | -2,300 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 9,869 | 19,684 | +9,815 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 18,607 | +18,607 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 9,195 | 17,808 | +8,613 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 17,427 | +17,427 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 16,528 | 17,350 | +822 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,361 | 16,946 | +11,585 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14,214 | 16,597 | +2,383 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 16,379 | +16,379 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,375 | 15,397 | +22 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0 | 13,300 | +13,300 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,685 | 12,880 | -805 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 12,698 | 12,594 | -104 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 11,858 | 11,469 | -389 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,157 | 10,866 | +9,709 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,946 | 10,774 | -1,172 | 0.02 | 0.02 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,021 | 10,193 | +172 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,735 | 10,062 | +4,327 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 10,382 | 9,982 | -400 | 0.00 | 0.00 | +0.00 | sell |
| Gotham Asset Management, LLC | 0 | 9,322 | +9,322 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,719 | 9,102 | -1,617 | 0.07 | 0.07 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 8,900 | +8,900 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,600 | 8,500 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 7,739 | +7,739 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 7,636 | +7,636 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 7,330 | +7,330 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 39,800 | 7,200 | -32,600 | 1.03 | 0.22 | -0.81 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 7,191 | +7,191 | 0.00 | 0.01 | +0.01 | buy |
| WINTON GROUP Ltd | 8,842 | 7,182 | -1,660 | 0.01 | 0.01 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 5,175 | 6,527 | +1,352 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 6,304 | +6,304 | 0.00 | 0.00 | +0.00 | buy |