| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 51,944 | 384,200 | +332,256 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 847,227 | 1,176,491 | +329,264 | 1.45 | 2.19 | +0.74 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 4,680,431 | 4,919,896 | +239,465 | 0.40 | 0.66 | +0.27 | buy |
| Invesco Ltd. | 11,833 | 177,070 | +165,237 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,414,363 | 1,518,757 | +104,394 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 1,237,500 | 1,337,500 | +100,000 | 0.23 | 0.33 | +0.10 | buy |
| Walleye Capital LLC | 0 | 80,341 | +80,341 | 0.00 | 0.01 | +0.01 | buy |
| VR Adviser, LLC | 540,453 | 610,808 | +70,355 | 0.43 | 0.65 | +0.22 | buy |
| BlackRock, Inc. | 1,390,800 | 1,459,795 | +68,995 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 487,956 | 545,701 | +57,745 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 57,064 | +57,064 | 0.00 | 0.23 | +0.23 | buy |
| STATE STREET CORP | 369,992 | 418,960 | +48,968 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,416,314 | 1,454,720 | +38,406 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 35,778 | +35,778 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 154,781 | 186,904 | +32,123 | 0.00 | 0.00 | +0.00 | buy |
| Rangeley Capital, LLC | 58,605 | 88,000 | +29,395 | 0.78 | 1.55 | +0.78 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 25,283 | +25,283 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 20,700 | +20,700 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 20,131 | +20,131 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 77,642 | 92,334 | +14,692 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 154,344 | 167,345 | +13,001 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 12,863 | +12,863 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,717 | 20,147 | +5,430 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 48,489 | 51,631 | +3,142 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,902 | 27,424 | +2,522 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 12,123 | 14,135 | +2,012 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,210 | 4,155 | +1,945 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,896 | +1,896 | 0.00 | 0.00 | +0.00 | buy |
| PharVision Advisers, LLC | 10,152 | 11,932 | +1,780 | 0.15 | 0.13 | -0.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 3,555 | 5,175 | +1,620 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 2,324 | 3,620 | +1,296 | 0.01 | 0.04 | +0.02 | buy |
| FMR LLC | 2,485 | 3,438 | +953 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 789 | 1,689 | +900 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 577 | 1,475 | +898 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 261 | +261 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 577 | 804 | +227 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 22 | 63 | +41 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 872 | 884 | +12 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,370 | 1,371 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,944 | 1,944 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 22,100 | 22,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 541,450 | 541,450 | 0 | 0.21 | 0.29 | +0.08 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | 6,995,858 | 0 | 1.25 | 1.62 | +0.38 | hold |
| Alyeska Investment Group, L.P. | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 966 | 966 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 13,685 | 13,685 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 553,268 | 553,268 | 0 | 0.53 | 0.87 | +0.34 | hold |
| Samsara BioCapital, LLC | 3,149,128 | 3,149,128 | 0 | 6.81 | 7.73 | +0.93 | hold |
| Woodline Partners LP | 282,585 | 282,585 | 0 | 0.02 | 0.03 | +0.01 | hold |
| SBI Securities Co., Ltd. | 50 | 50 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Fortitude Family Office, LLC | 71 | 71 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalio Capital Management, LP | 294,360 | 294,360 | 0 | 0.65 | 1.02 | +0.37 | hold |
| TRV GP VI, LLC | 4,211,659 | 4,211,659 | 0 | 69.32 | 72.26 | +2.94 | hold |
| TRV GP V, LLC | 6,215,591 | 6,215,591 | 0 | 39.66 | 33.07 | -6.59 | hold |
| Siren, L.L.C. | 2,202,514 | 2,202,514 | 0 | 1.20 | 1.62 | +0.42 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | 222,702 | 0 | 0.00 | 0.01 | +0.00 | hold |
| US BANCORP \DE\ | 265 | 265 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,945 | 1,945 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,900 | 2,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 634 | 634 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 143 | 143 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMERICA BANK | 212 | 0 | -212 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 605 | 0 | -605 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 28,572 | 27,604 | -968 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,225 | 959 | -1,266 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 10,101 | 8,736 | -1,365 | 0.00 | 0.00 | +0.00 | sell |
| Quarry LP | 3,601 | 1,736 | -1,865 | 0.01 | 0.01 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,697 | 9,791 | -1,906 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 3,400 | 0 | -3,400 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 35,706 | 30,102 | -5,604 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 7,173 | 249 | -6,924 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 10,125 | 0 | -10,125 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 10,737 | 0 | -10,737 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 12,200 | 0 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 72,335 | 59,046 | -13,289 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 16,761 | 0 | -16,761 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 22,330 | 0 | -22,330 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 23,525 | 0 | -23,525 | 0.01 | 0.00 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 23,527 | 0 | -23,527 | 0.02 | 0.00 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 24,142 | 0 | -24,142 | 0.01 | 0.00 | -0.01 | sell |
| Logos Global Management LP | 109,202 | 83,548 | -25,654 | 0.15 | 0.16 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 28,700 | 0 | -28,700 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 57,971 | 23,961 | -34,010 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 99,213 | 51,495 | -47,718 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 75,456 | 18,260 | -57,196 | 0.06 | 0.02 | -0.04 | sell |
| Deep Track Capital, LP | 121,716 | 0 | -121,716 | 0.04 | 0.00 | -0.04 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,506 | 0 | -166,506 | 0.00 | 0.00 | -0.00 | sell |
| Checkpoint Capital L.P. | 586,473 | 283,158 | -303,315 | 2.89 | 1.78 | -1.10 | sell |
| BVF INC/IL | 4,396,124 | 4,015,790 | -380,334 | 1.66 | 3.06 | +1.40 | sell |
| Sio Capital Management, LLC | 584,435 | 189,199 | -395,236 | 2.48 | 0.90 | -1.58 | sell |