| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 6,995,858 | +6,995,858 | 0.00 | 2.13 | +2.13 | buy |
| Samsara BioCapital, LLC | 0 | 2,768,520 | +2,768,520 | 0.00 | 8.70 | +8.70 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 2,589,553 | +2,589,553 | 0.00 | 0.49 | +0.49 | buy |
| BVF INC/IL | 0 | 2,452,024 | +2,452,024 | 0.00 | 1.90 | +1.90 | buy |
| Siren, L.L.C. | 0 | 2,202,514 | +2,202,514 | 0.00 | 2.23 | +2.23 | buy |
| Deep Track Capital, LP | 0 | 1,912,929 | +1,912,929 | 0.00 | 1.64 | +1.64 | buy |
| BlackRock, Inc. | 0 | 1,677,135 | +1,677,135 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 1,674,357 | +1,674,357 | 0.00 | 0.01 | +0.01 | buy |
| Avoro Capital Advisors LLC | 0 | 1,110,000 | +1,110,000 | 0.00 | 0.36 | +0.36 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,096,302 | +1,096,302 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 0 | 1,002,958 | +1,002,958 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 985,032 | +985,032 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 861,814 | +861,814 | 0.00 | 0.38 | +0.38 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 750,000 | +750,000 | 0.00 | 0.48 | +0.48 | buy |
| Soleus Capital Management, L.P. | 0 | 675,409 | +675,409 | 0.00 | 1.17 | +1.17 | buy |
| Cormorant Asset Management, LP | 0 | 560,000 | +560,000 | 0.00 | 0.70 | +0.70 | buy |
| Casdin Capital, LLC | 0 | 553,268 | +553,268 | 0.00 | 0.85 | +0.85 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 518,588 | +518,588 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 404,882 | +404,882 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 380,577 | +380,577 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 300,000 | +300,000 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 0 | 300,000 | +300,000 | 0.00 | 0.05 | +0.05 | buy |
| STATE STREET CORP | 0 | 272,776 | +272,776 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 271,687 | +271,687 | 0.00 | 1.75 | +1.75 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 147,886 | +147,886 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 0 | 147,776 | +147,776 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 139,616 | +139,616 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 134,202 | +134,202 | 0.00 | 0.36 | +0.36 | buy |
| UBS Group AG | 0 | 108,453 | +108,453 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 78,744 | +78,744 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 69,460 | +69,460 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 38,093 | +38,093 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 38,015 | +38,015 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 28,785 | +28,785 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 26,208 | +26,208 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 22,695 | +22,695 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 22,095 | +22,095 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 20,204 | +20,204 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 19,995 | +19,995 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 0 | 16,394 | +16,394 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 14,633 | +14,633 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 12,154 | +12,154 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 12,118 | +12,118 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 0 | 11,555 | +11,555 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 10,651 | +10,651 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 10,519 | +10,519 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 10,419 | +10,419 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 9,236 | +9,236 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 8,095 | +8,095 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,680 | +2,680 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,251 | +2,251 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,944 | +1,944 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,840 | +1,840 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,370 | +1,370 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,093 | +1,093 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 634 | +634 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 266 | +266 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |