| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 1,454,720 | 2,715,129 | +1,260,409 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 0 | 620,811 | +620,811 | 0.00 | 1.32 | +1.32 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 0 | 546,100 | +546,100 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 18,260 | 383,368 | +365,108 | 0.02 | 0.45 | +0.44 | buy |
| BlackRock, Inc. | 1,459,795 | 1,801,328 | +341,533 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 226,901 | +226,901 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 418,960 | 540,028 | +121,068 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 103,985 | +103,985 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 282,585 | 385,310 | +102,725 | 0.03 | 0.04 | +0.02 | buy |
| FEDERATED HERMES, INC. | 0 | 78,905 | +78,905 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 78,682 | +78,682 | 0.00 | 0.56 | +0.56 | buy |
| CITADEL ADVISORS LLC | 0 | 75,945 | +75,945 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 8,736 | 68,338 | +59,602 | 0.00 | 0.00 | +0.00 | buy |
| Numerai GP LLC | 0 | 45,866 | +45,866 | 0.00 | 0.15 | +0.15 | buy |
| JANE STREET GROUP, LLC | 0 | 44,070 | +44,070 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 44,005 | +44,005 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 37,867 | +37,867 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 34,944 | +34,944 | 0.00 | 0.02 | +0.02 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 30,877 | +30,877 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 545,701 | 572,734 | +27,033 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 35,778 | 61,370 | +25,592 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 25,283 | 50,689 | +25,406 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 23,315 | +23,315 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 18,550 | +18,550 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 18,053 | +18,053 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 16,852 | +16,852 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 14,847 | +14,847 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 14,600 | +14,600 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 14,090 | +14,090 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,896 | 15,310 | +13,414 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,283 | +13,283 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 10,810 | +10,810 | 0.00 | 0.07 | +0.07 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 10,594 | +10,594 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 10,457 | +10,457 | 0.00 | 0.08 | +0.08 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,296 | +10,296 | 0.00 | 0.02 | +0.02 | buy |
| Baader Bank Aktiengesellschaft | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| Atom Investors LP | 0 | 9,791 | +9,791 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 59,046 | 68,817 | +9,771 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 249 | 9,561 | +9,312 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 8,971 | +8,971 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 8,399 | +8,399 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 0 | 8,300 | +8,300 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 30,102 | 38,147 | +8,045 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 7,826 | +7,826 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 20,147 | 26,529 | +6,382 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 20,700 | 25,700 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 51,631 | 55,332 | +3,701 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,571 | +3,571 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 3,170 | +3,170 | 0.00 | 0.02 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,900 | 5,600 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,176 | +2,176 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 23,961 | 25,798 | +1,837 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,155 | 5,449 | +1,294 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 1,256 | +1,256 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 959 | 2,156 | +1,197 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 878 | +878 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,135 | 14,879 | +744 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 92,334 | 92,809 | +475 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 340 | +340 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 186,904 | 187,241 | +337 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 322 | +322 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 143 | 341 | +198 | 0.00 | 0.00 | +0.00 | buy |
| N.E.W. Advisory Services LLC | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 149 | +149 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,791 | 9,934 | +143 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 804 | 916 | +112 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 634 | 672 | +38 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 966 | 989 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 50 | 55 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 884 | 888 | +4 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,944 | 1,944 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 6,995,858 | 6,995,858 | 0 | 1.62 | 2.00 | +0.38 | hold |
| Alyeska Investment Group, L.P. | 35,000 | 35,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 13,685 | 13,685 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Casdin Capital, LLC | 553,268 | 553,268 | 0 | 0.87 | 0.96 | +0.09 | hold |
| VR Adviser, LLC | 610,808 | 610,808 | 0 | 0.65 | 0.84 | +0.19 | hold |
| Avoro Capital Advisors LLC | 1,337,500 | 1,337,500 | 0 | 0.33 | 0.37 | +0.04 | hold |
| EverSource Wealth Advisors, LLC | 63 | 63 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 261 | 261 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 3,149,128 | 3,149,128 | 0 | 7.73 | 9.06 | +1.32 | hold |
| Fortitude Family Office, LLC | 71 | 71 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalio Capital Management, LP | 294,360 | 294,360 | 0 | 1.02 | 1.45 | +0.43 | hold |
| TRV GP VI, LLC | 4,211,659 | 4,211,659 | 0 | 72.26 | 79.05 | +6.79 | hold |
| TRV GP V, LLC | 6,215,591 | 6,215,591 | 0 | 33.07 | 40.38 | +7.30 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,175 | 5,175 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | 222,702 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Legal & General Group Plc | 1,945 | 1,945 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,371 | 1,316 | -55 | 0.00 | 0.00 | +0.00 | sell |
| Arax Advisory Partners | 63 | 3 | -60 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 265 | 190 | -75 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 3,438 | 3,307 | -131 | 0.00 | 0.00 | +0.00 | sell |
| OSAIC HOLDINGS, INC. | 12,863 | 12,693 | -170 | 0.00 | 0.00 | +0.00 | sell |
| Sterling Capital Management LLC | 1,475 | 1,232 | -243 | 0.00 | 0.00 | +0.00 | sell |
| GROUP ONE TRADING LLC | 1,689 | 944 | -745 | 0.00 | 0.00 | -0.00 | sell |
| Quarry LP | 1,736 | 724 | -1,012 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 27,604 | 26,419 | -1,185 | 0.00 | 0.00 | +0.00 | sell |