| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,984,808 | 8,514,590 | +1,529,782 | 4.70 | 5.16 | +0.46 | buy |
| BlackRock, Inc. | 5,064,180 | 6,256,288 | +1,192,108 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 24,632 | 867,465 | +842,833 | 0.00 | 0.04 | +0.03 | buy |
| STATE STREET CORP | 2,647,054 | 3,437,590 | +790,536 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 769,947 | +769,947 | 0.00 | 0.50 | +0.50 | buy |
| AMERICAN CENTURY COMPANIES INC | 4,907 | 726,154 | +721,247 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 520,213 | 1,177,109 | +656,896 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 627,185 | +627,185 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,596,864 | 2,153,277 | +556,413 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 493,596 | +493,596 | 0.00 | 0.74 | +0.74 | buy |
| Logos Global Management LP | 575,000 | 1,000,000 | +425,000 | 2.00 | 3.06 | +1.05 | buy |
| FMR LLC | 3,764,844 | 4,161,493 | +396,649 | 0.01 | 0.01 | -0.00 | buy |
| EcoR1 Capital, LLC | 1,102,000 | 1,494,300 | +392,300 | 3.19 | 5.26 | +2.08 | buy |
| TORONTO DOMINION BANK | 0 | 287,632 | +287,632 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 108,039 | 304,167 | +196,128 | 0.00 | 0.01 | +0.01 | buy |
| FEDERATED HERMES, INC. | 148,750 | 311,236 | +162,486 | 0.02 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 519,669 | 677,912 | +158,243 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,652,980 | 3,805,010 | +152,030 | 0.03 | 0.03 | -0.00 | buy |
| Foresite Capital Management VI LLC | 2,221,474 | 2,369,574 | +148,100 | 32.67 | 26.20 | -6.46 | buy |
| CITIGROUP INC | 14,196 | 135,225 | +121,029 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,288,948 | 1,398,948 | +110,000 | 17.67 | 15.92 | -1.75 | buy |
| BARCLAYS PLC | 11,499 | 118,613 | +107,114 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 378,480 | 484,461 | +105,981 | 1.22 | 1.21 | -0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542,378 | 627,185 | +84,807 | 0.01 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,290,087 | 1,374,149 | +84,062 | 0.02 | 0.03 | +0.01 | buy |
| Foresite Capital Management V, LLC | 1,004,050 | 1,079,050 | +75,000 | 25.08 | 21.17 | -3.91 | buy |
| Bank of New York Mellon Corp | 167,030 | 233,419 | +66,389 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 61,729 | +61,729 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 128,414 | 188,420 | +60,006 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 51,849 | +51,849 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 24,600 | 76,220 | +51,620 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 9,700 | 53,455 | +43,755 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 46,610 | 89,417 | +42,807 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 156,454 | 197,514 | +41,060 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 19,380 | 46,690 | +27,310 | 0.02 | 0.04 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 14,171 | 41,311 | +27,140 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 948,267 | 972,800 | +24,533 | 1.40 | 1.31 | -0.09 | buy |
| LORD, ABBETT & CO. LLC | 340,197 | 364,539 | +24,342 | 0.08 | 0.07 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 20,964 | +20,964 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 68,737 | 89,218 | +20,481 | 0.02 | 0.03 | +0.01 | buy |
| LMR Partners LLP | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 71,082 | 90,849 | +19,767 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 136,841 | 155,390 | +18,549 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 84,400 | 101,700 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 14,477 | +14,477 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 6,600 | 20,800 | +14,200 | 0.00 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,609 | 23,354 | +11,745 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,811 | +10,811 | 0.00 | 0.06 | +0.06 | buy |
| MetLife Investment Management, LLC | 32,604 | 43,027 | +10,423 | 0.01 | 0.01 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 10,100 | +10,100 | 0.00 | 0.02 | +0.02 | buy |
| Curated Wealth Partners LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,796 | 25,996 | +8,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,499 | 57,909 | +6,410 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 12,300 | 18,554 | +6,254 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 12,874 | 18,868 | +5,994 | 0.02 | 0.02 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 5,800 | +5,800 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,209 | 21,767 | +5,558 | 0.01 | 0.01 | +0.00 | buy |
| Tidal Investments LLC | 63,163 | 68,702 | +5,539 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 63,163 | 68,702 | +5,539 | 0.29 | 0.16 | -0.13 | buy |
| Clearbridge Investments, LLC | 730,283 | 735,736 | +5,453 | 0.04 | 0.04 | +0.00 | buy |
| Ground Swell Capital, LLC | 0 | 4,765 | +4,765 | 0.00 | 0.37 | +0.37 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 4,407 | +4,407 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 4,185 | +4,185 | 0.00 | 0.00 | +0.00 | buy |
| DeepCurrents Investment Group LLC | 0 | 4,133 | +4,133 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 3,553 | +3,553 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,882 | 16,427 | +3,545 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 3,478 | +3,478 | 0.00 | 0.02 | +0.02 | buy |
| Russell Investments Group, Ltd. | 163,172 | 166,633 | +3,461 | 0.01 | 0.01 | -0.00 | buy |
| Neuberger Berman Group LLC | 0 | 2,970 | +2,970 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 2,952 | +2,952 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,747 | 13,979 | +2,232 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 38,008 | 40,062 | +2,054 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 9,500 | 11,500 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 11,090 | 13,015 | +1,925 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 1,861 | +1,861 | 0.00 | 0.02 | +0.02 | buy |
| Ameritas Investment Partners, Inc. | 4,840 | 6,698 | +1,858 | 0.01 | 0.01 | +0.00 | buy |
| XPONANCE, INC. | 5,469 | 7,246 | +1,777 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 14,617 | 16,381 | +1,764 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 5,359 | 7,095 | +1,736 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 4,267 | 5,642 | +1,375 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 6,483 | 7,761 | +1,278 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 11,439 | 12,641 | +1,202 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 20,700 | 21,900 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| Total Clarity Wealth Management, Inc. | 4,600 | 5,719 | +1,119 | 0.07 | 0.08 | +0.01 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,130,501 | 1,131,500 | +999 | 21.77 | 21.94 | +0.17 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 976 | +976 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 5,001 | 5,958 | +957 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 839 | +839 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 801 | +801 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 6,096 | 6,645 | +549 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,721 | 3,255 | +534 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 3,904 | 4,416 | +512 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,840 | 27,216 | +376 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5,521 | 5,894 | +373 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,288 | 1,595 | +307 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 6,373 | 6,676 | +303 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 38 | 330 | +292 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 76 | 311 | +235 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 3,579 | 3,810 | +231 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 12,349 | 12,553 | +204 | 0.00 | 0.00 | +0.00 | buy |