| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,984,808 | 8,514,590 | +1,529,782 | 4.70 | 5.16 | +0.46 | buy |
| EcoR1 Capital, LLC | 1,102,000 | 1,494,300 | +392,300 | 3.17 | 5.16 | +2.00 | buy |
| Voleon Capital Management LP | 12,874 | 18,868 | +5,994 | 0.02 | 0.02 | +0.01 | buy |
| TEMA ETFS LLC | 63,163 | 68,702 | +5,539 | 0.29 | 0.16 | -0.13 | buy |
| Clearbridge Investments, LLC | 730,283 | 735,736 | +5,453 | 0.04 | 0.04 | +0.00 | buy |
| Total Clarity Wealth Management, Inc. | 4,600 | 5,719 | +1,119 | 0.07 | 0.08 | +0.01 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,130,501 | 1,131,500 | +999 | 21.77 | 21.94 | +0.17 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 233 | 313 | +80 | 0.01 | 0.01 | +0.00 | buy |
| J.Safra Asset Management Corp | 276 | 238 | -38 | 0.00 | 0.00 | -0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 369,985 | 369,839 | -146 | 0.41 | 0.35 | -0.06 | sell |
| AMI ASSET MANAGEMENT CORP | 20,129 | 19,398 | -731 | 0.09 | 0.08 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 14,984 | 14,037 | -947 | 0.08 | 0.06 | -0.02 | sell |
| HighVista Strategies LLC | 19,914 | 18,867 | -1,047 | 0.37 | 0.31 | -0.07 | sell |
| Knights of Columbus Asset Advisors LLC | 23,200 | 20,870 | -2,330 | 0.09 | 0.07 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 186,312 | 155,354 | -30,958 | 0.34 | 0.46 | +0.12 | sell |
| PFM Health Sciences, LP | 165,925 | 128,286 | -37,639 | 1.02 | 0.78 | -0.24 | sell |
| TimesSquare Capital Management, LLC | 253,708 | 210,884 | -42,824 | 100.00 | 100.00 | 0.00 | sell |
| Candriam S.C.A. | 542,036 | 469,170 | -72,866 | 0.19 | 0.15 | -0.04 | sell |
| Opaleye Management Inc. | 94,800 | 17,789 | -77,011 | 0.85 | 0.11 | -0.73 | sell |