| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Decheng Capital LLC | 0 | 5,458,810 | +5,458,810 | 0.00 | 32.14 | +32.14 | buy |
| TCG Crossover Management, LLC | 0 | 3,570,206 | +3,570,206 | 0.00 | 12.39 | +12.39 | buy |
| VANGUARD GROUP INC | 0 | 2,225,018 | +2,225,018 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 0 | 1,884,191 | +1,884,191 | 0.00 | 2.27 | +2.27 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,521,432 | +1,521,432 | 0.00 | 0.04 | +0.04 | buy |
| Avidity Partners Management LP | 0 | 1,454,765 | +1,454,765 | 0.00 | 2.27 | +2.27 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,397,433 | +1,397,433 | 0.00 | 0.78 | +0.78 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,304,105 | +1,304,105 | 0.00 | 1.01 | +1.01 | buy |
| BRAIDWELL LP | 0 | 1,130,235 | +1,130,235 | 0.00 | 1.60 | +1.60 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 992,118 | +992,118 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 929,752 | +929,752 | 0.00 | 0.01 | +0.01 | buy |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 0 | 915,501 | +915,501 | 0.00 | 96.81 | +96.81 | buy |
| FRANKLIN RESOURCES INC | 0 | 848,092 | +848,092 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 0 | 800,000 | +800,000 | 0.00 | 1.55 | +1.55 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 770,000 | +770,000 | 0.00 | 1.43 | +1.43 | buy |
| Holocene Advisors, LP | 0 | 766,625 | +766,625 | 0.00 | 0.12 | +0.12 | buy |
| Polar Capital Holdings Plc | 0 | 729,166 | +729,166 | 0.00 | 0.17 | +0.17 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 708,711 | +708,711 | 0.00 | 0.02 | +0.02 | buy |
| Avoro Capital Advisors LLC | 0 | 700,000 | +700,000 | 0.00 | 0.36 | +0.36 | buy |
| Foresite Capital Management V, LLC | 0 | 692,550 | +692,550 | 0.00 | 28.54 | +28.54 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 558,197 | +558,197 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 0 | 525,199 | +525,199 | 0.00 | 0.21 | +0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 504,216 | +504,216 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 455,000 | +455,000 | 0.00 | 0.04 | +0.04 | buy |
| RTW INVESTMENTS, LP | 0 | 413,670 | +413,670 | 0.00 | 0.27 | +0.27 | buy |
| STATE STREET CORP | 0 | 350,831 | +350,831 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.73 | +0.73 | buy |
| Ally Bridge Group (NY) LLC | 0 | 320,378 | +320,378 | 0.00 | 7.82 | +7.82 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 0 | 306,226 | +306,226 | 0.00 | 0.05 | +0.05 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 1.39 | +1.39 | buy |
| CITADEL ADVISORS LLC | 0 | 276,461 | +276,461 | 0.00 | 0.01 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 259,888 | +259,888 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 0 | 224,073 | +224,073 | 0.00 | 0.14 | +0.14 | buy |
| Soleus Capital Management, L.P. | 0 | 217,871 | +217,871 | 0.00 | 0.84 | +0.84 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 198,807 | +198,807 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 196,107 | +196,107 | 0.00 | 0.10 | +0.10 | buy |
| Point72 Asset Management, L.P. | 0 | 186,237 | +186,237 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 0 | 183,004 | +183,004 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 0 | 170,859 | +170,859 | 0.00 | 0.19 | +0.19 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 169,352 | +169,352 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 125,000 | +125,000 | 0.00 | 0.65 | +0.65 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 107,957 | +107,957 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 0 | 106,319 | +106,319 | 0.00 | 0.05 | +0.05 | buy |
| JANE STREET GROUP, LLC | 0 | 76,353 | +76,353 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 73,724 | +73,724 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 64,543 | +64,543 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 63,774 | +63,774 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 47,540 | +47,540 | 0.00 | 0.04 | +0.04 | buy |
| STEMPOINT CAPITAL LP | 0 | 40,723 | +40,723 | 0.00 | 0.48 | +0.48 | buy |
| RHUMBLINE ADVISERS | 0 | 30,289 | +30,289 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 28,672 | +28,672 | 0.00 | 0.01 | +0.01 | buy |
| Blackstone Inc. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Sicart Associates LLC | 0 | 25,000 | +25,000 | 0.00 | 0.40 | +0.40 | buy |
| Ghisallo Capital Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.13 | +0.13 | buy |
| UBS Group AG | 0 | 23,323 | +23,323 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 18,523 | +18,523 | 0.00 | 0.01 | +0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 18,354 | +18,354 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 0 | 16,353 | +16,353 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 14,200 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 14,147 | +14,147 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 13,616 | +13,616 | 0.00 | 0.02 | +0.02 | buy |
| Scientech Research LLC | 0 | 12,194 | +12,194 | 0.00 | 0.28 | +0.28 | buy |
| Invesco Ltd. | 0 | 12,183 | +12,183 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 12,106 | +12,106 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 11,836 | +11,836 | 0.00 | 0.04 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 11,198 | +11,198 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 11,149 | +11,149 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 10,693 | +10,693 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 9,623 | +9,623 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 0 | 9,580 | +9,580 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 9,538 | +9,538 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 7,449 | +7,449 | 0.00 | 0.03 | +0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 7,000 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 6,956 | +6,956 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 5,728 | +5,728 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 4,933 | +4,933 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 4,800 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 4,284 | +4,284 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 4,100 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 2,341 | +2,341 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,320 | +2,320 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,162 | +2,162 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 2,050 | +2,050 | 0.00 | 0.02 | +0.02 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 1,246 | +1,246 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 781 | +781 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 157 | +157 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |