| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 308,259 | 1,667,174 | +1,358,915 | 0.02 | 0.11 | +0.09 | buy |
| ORBIMED ADVISORS LLC | 1,431,114 | 2,471,994 | +1,040,880 | 0.85 | 1.45 | +0.60 | buy |
| MARSHALL WACE, LLP | 1,458,072 | 2,418,456 | +960,384 | 0.05 | 0.08 | +0.03 | buy |
| UBS Group AG | 1,013,891 | 1,704,718 | +690,827 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 249,001 | 596,056 | +347,055 | 0.01 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 4,061,130 | 4,355,060 | +293,930 | 0.00 | 0.00 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 289,823 | +289,823 | 0.00 | 2.27 | +2.27 | buy |
| MORGAN STANLEY | 725,227 | 945,081 | +219,854 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,910,470 | 2,125,208 | +214,738 | 0.01 | 0.01 | -0.00 | buy |
| Foresite Capital Management V, LLC | 692,550 | 859,050 | +166,500 | 16.53 | 24.01 | +7.49 | buy |
| Opaleye Management Inc. | 0 | 163,988 | +163,988 | 0.00 | 0.89 | +0.89 | buy |
| Woodline Partners LP | 628,885 | 764,357 | +135,472 | 0.12 | 0.12 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 209,518 | 340,599 | +131,081 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,156,670 | 1,279,234 | +122,564 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 2,433,593 | 2,545,098 | +111,505 | 0.00 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 108,302 | +108,302 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 2,519,705 | 2,611,662 | +91,957 | 4.77 | 5.47 | +0.71 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 89,833 | +89,833 | 0.00 | 0.04 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 215,750 | 301,134 | +85,384 | 1.28 | 1.42 | +0.14 | buy |
| Polar Capital Holdings Plc | 967,055 | 1,042,860 | +75,805 | 0.16 | 0.16 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 60,565 | 134,400 | +73,835 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 674,607 | 747,829 | +73,222 | 0.02 | 0.02 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 945,194 | 1,014,596 | +69,402 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 0 | 67,717 | +67,717 | 0.00 | 0.12 | +0.12 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,817,887 | 1,882,577 | +64,690 | 0.02 | 0.02 | -0.00 | buy |
| Jain Global LLC | 0 | 54,050 | +54,050 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 125,902 | 179,363 | +53,461 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,669 | 81,985 | +44,316 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 44,051 | +44,051 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 1,923,584 | 1,967,489 | +43,905 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,275,891 | 1,318,934 | +43,043 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 433,860 | 471,764 | +37,904 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 32,158 | +32,158 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 24,723 | +24,723 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 71,636 | 95,882 | +24,246 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 8,329 | 28,612 | +20,283 | 0.01 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 8,329 | 28,612 | +20,283 | 0.10 | 0.21 | +0.11 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 19,381 | +19,381 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 16,676 | +16,676 | 0.00 | 0.06 | +0.06 | buy |
| CIBC WORLD MARKETS CORP | 0 | 12,009 | +12,009 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 135,567 | 147,560 | +11,993 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 427,760 | 439,278 | +11,518 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 224,582 | 235,194 | +10,612 | 0.09 | 0.09 | +0.01 | buy |
| Legal & General Group Plc | 29,262 | 39,507 | +10,245 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,856 | 13,456 | +7,600 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 28,234 | 34,147 | +5,913 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,787 | 22,556 | +5,769 | 0.00 | 0.01 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 5,686 | +5,686 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 69,016 | 74,689 | +5,673 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,479 | +5,479 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,080 | 35,522 | +5,442 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 3,500 | 8,100 | +4,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,893 | 13,967 | +3,074 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 29,026 | 31,815 | +2,789 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 6,000 | 8,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 52 | 2,110 | +2,058 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 54,690 | 56,399 | +1,709 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 79,600 | 81,100 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 10,342 | 11,647 | +1,305 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 257,157 | 258,090 | +933 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,340 | 15,270 | +930 | 0.04 | 0.03 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 76,522 | 77,435 | +913 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 0 | 840 | +840 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 27,069 | 27,754 | +685 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,805 | 5,475 | +670 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 72 | 465 | +393 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 339 | 694 | +355 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,420 | 1,731 | +311 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,254 | 2,547 | +293 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 1,621 | 1,865 | +244 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 192 | +192 | 0.00 | 0.00 | +0.00 | buy |
| SUMMIT SECURITIES GROUP LLC | 0 | 163 | +163 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,692 | 2,846 | +154 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 6 | 144 | +138 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 90 | 213 | +123 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 100 | 200 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,853 | 11,944 | +91 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 58 | +58 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 42 | +42 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 25 | 45 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,768 | 38,768 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 22,305 | 22,305 | 0 | 0.24 | 0.21 | -0.03 | hold |
| Handelsbanken Fonder AB | 13,300 | 13,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AdvisorNet Financial, Inc | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 223 | 223 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,701,216 | 1,701,216 | 0 | 0.74 | 0.64 | -0.10 | hold |
| Cormorant Asset Management, LP | 775,000 | 775,000 | 0 | 1.22 | 1.44 | +0.22 | hold |
| Yu Fan | 163,456 | 163,456 | 0 | 2.41 | 4.11 | +1.70 | hold |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.26 | 0.21 | -0.04 | hold |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 495,526 | 495,526 | 0 | 32.51 | 31.67 | -0.84 | hold |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 10.29 | 12.26 | +1.97 | hold |
| Frazier Life Sciences Management, L.P. | 770,000 | 770,000 | 0 | 0.92 | 0.86 | -0.05 | hold |
| Washington Trust Advisors, Inc. | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |