| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 1,431,114 | 2,471,994 | +1,040,880 | 0.85 | 1.45 | +0.60 | buy |
| JANUS HENDERSON GROUP PLC | 1,485,843 | 1,277,741 | +208,102 | 0.02 | 0.02 | 0.00 | sell |
| Foresite Capital Management V, LLC | 692,550 | 859,050 | +166,500 | 16.53 | 24.01 | +7.49 | buy |
| Woodline Partners LP | 628,885 | 764,357 | +135,472 | 0.12 | 0.12 | -0.00 | buy |
| Kynam Capital Management, LP | 2,519,705 | 2,611,662 | +91,957 | 4.77 | 5.47 | +0.71 | buy |
| ADAR1 Capital Management, LLC | 215,750 | 301,134 | +85,384 | 1.28 | 1.42 | +0.14 | buy |
| Polar Capital Holdings Plc | 967,055 | 1,042,860 | +75,805 | 0.16 | 0.16 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 945,194 | 1,014,596 | +69,402 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 8,329 | 28,612 | +20,283 | 0.01 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 8,329 | 28,612 | +20,283 | 0.10 | 0.21 | +0.11 | buy |
| ArrowMark Colorado Holdings LLC | 224,582 | 235,194 | +10,612 | 0.09 | 0.09 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 30,197 | 27,522 | +2,675 | 0.00 | 0.00 | 0.00 | sell |
| ALPS ADVISORS INC | 54,690 | 56,399 | +1,709 | 0.01 | 0.01 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 257,157 | 258,090 | +933 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 14,340 | 15,270 | +930 | 0.04 | 0.03 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,420 | 1,731 | +311 | 0.00 | 0.00 | +0.00 | buy |
| iA Global Asset Management Inc. | 45,890 | 45,550 | -340 | 0.02 | 0.02 | -0.00 | sell |
| PROFUND ADVISORS LLC | 15,515 | 15,144 | -371 | 0.02 | 0.02 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 851,593 | 850,695 | -898 | 0.46 | 0.41 | -0.05 | sell |
| Cinctive Capital Management LP | 22,608 | 18,955 | -3,653 | 0.03 | 0.04 | +0.00 | sell |
| Rafferty Asset Management, LLC | 78,721 | 71,426 | -7,295 | 0.01 | 0.01 | -0.00 | sell |
| Saturn V Capital Management LP | 593,262 | 577,696 | -15,566 | 6.66 | 7.14 | +0.48 | sell |
| Soleus Capital Management, L.P. | 328,585 | 303,585 | -25,000 | 0.71 | 0.58 | -0.13 | sell |
| TimesSquare Capital Management, LLC | 546,904 | 517,258 | -29,646 | 100.00 | 100.00 | 0.00 | sell |
| CenterBook Partners LP | 236,108 | 203,128 | -32,980 | 0.40 | 0.32 | -0.09 | sell |
| Ally Bridge Group (NY) LLC | 174,048 | 132,298 | -41,750 | 4.28 | 2.92 | -1.36 | sell |
| Avidity Partners Management LP | 1,097,800 | 980,942 | -116,858 | 3.14 | 4.95 | +1.82 | sell |