| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 2,012,127 | 6,984,808 | +4,972,681 | 0.84 | 4.70 | +3.87 | buy |
| T. Rowe Price Investment Management, Inc. | 422,592 | 6,720,389 | +6,297,797 | 0.01 | 0.31 | +0.30 | buy |
| Decheng Capital LLC | 6,371,669 | 6,371,669 | 0 | 35.59 | 65.21 | +29.62 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 5,999,790 | 5,371,232 | -628,558 | 0.04 | 0.07 | +0.02 | sell |
| BlackRock, Inc. | 4,843,242 | 5,064,180 | +220,938 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 4,298,173 | 3,764,844 | -533,329 | 0.01 | 0.01 | +0.00 | sell |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 5.04 | 7.11 | +2.06 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,443,144 | 3,652,980 | +209,836 | 0.02 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 2,996,695 | 2,647,054 | -349,641 | 0.00 | 0.01 | +0.00 | sell |
| Foresite Capital Management VI LLC | 2,221,474 | 2,221,474 | 0 | 27.88 | 32.67 | +4.79 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,511,533 | 1,596,864 | +85,331 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,561,574 | 1,507,005 | -54,569 | 0.02 | 0.02 | +0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 1,190,053 | 1,449,364 | +259,311 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 1,923,746 | 1,311,978 | -611,768 | 0.02 | 0.02 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,613,425 | 1,290,087 | -323,338 | 0.02 | 0.02 | -0.00 | sell |
| Avidity Partners Management LP | 1,472,699 | 1,288,948 | -183,751 | 17.64 | 17.67 | +0.03 | sell |
| GOLDMAN SACHS GROUP INC | 1,324,603 | 1,159,239 | -165,364 | 0.01 | 0.01 | +0.00 | sell |
| ACORN CAPITAL ADVISORS, LLC | 1,131,501 | 1,130,501 | -1,000 | 15.92 | 21.77 | +5.85 | sell |
| EcoR1 Capital, LLC | 772,000 | 1,102,000 | +330,000 | 1.46 | 3.19 | +1.72 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,090,894 | 1,064,966 | -25,928 | 0.01 | 0.01 | +0.01 | sell |
| Foresite Capital Management V, LLC | 1,004,050 | 1,004,050 | 0 | 25.36 | 25.08 | -0.28 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 999,623 | +999,623 | 0.00 | 0.50 | +0.50 | buy |
| BRAIDWELL LP | 1,870,571 | 984,783 | -885,788 | 2.48 | 2.22 | -0.26 | sell |
| ORBIMED ADVISORS LLC | 1,516,550 | 948,267 | -568,283 | 1.29 | 1.40 | +0.11 | sell |
| Clearbridge Investments, LLC | 705,014 | 730,283 | +25,269 | 0.02 | 0.04 | +0.02 | buy |
| Polar Capital Holdings Plc | 1,098,662 | 704,461 | -394,201 | 0.21 | 0.21 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 8,000 | 674,000 | +666,000 | 0.00 | 0.27 | +0.27 | buy |
| Logos Global Management LP | 200,000 | 575,000 | +375,000 | 0.55 | 2.00 | +1.45 | buy |
| JPMORGAN CHASE & CO | 586,829 | 559,586 | -27,243 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542,695 | 542,378 | -317 | 0.00 | 0.01 | +0.00 | sell |
| Candriam S.C.A. | 797,615 | 542,036 | -255,579 | 0.17 | 0.19 | +0.03 | sell |
| MORGAN STANLEY | 545,019 | 520,213 | -24,806 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 481,940 | 519,669 | +37,729 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 492,500 | 492,891 | +391 | 0.08 | 0.13 | +0.05 | buy |
| JENNISON ASSOCIATES LLC | 282,506 | 476,136 | +193,630 | 0.01 | 0.02 | +0.02 | buy |
| Fisher Asset Management, LLC | 0 | 465,033 | +465,033 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 530,758 | 456,012 | -74,746 | 0.04 | 0.06 | +0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 461,132 | 438,673 | -22,459 | 0.00 | 0.01 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 399,858 | +399,858 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 151,363 | 399,392 | +248,029 | 0.01 | 0.05 | +0.04 | buy |
| Pictet Asset Management Holding SA | 1,349,527 | 398,005 | -951,522 | 0.05 | 0.03 | -0.03 | sell |
| Caption Management, LLC | 306,846 | 378,480 | +71,634 | 0.56 | 1.22 | +0.66 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 312,445 | 369,985 | +57,540 | 0.20 | 0.41 | +0.21 | buy |
| LORD, ABBETT & CO. LLC | 125,636 | 340,197 | +214,561 | 0.02 | 0.08 | +0.06 | buy |
| FIRST TRUST ADVISORS LP | 181,798 | 333,192 | +151,394 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 240,477 | 311,523 | +71,046 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 186,448 | 288,756 | +102,308 | 0.01 | 0.02 | +0.01 | buy |
| TimesSquare Capital Management, LLC | 426,019 | 253,708 | -172,311 | 0.27 | 0.29 | +0.02 | sell |
| STEMPOINT CAPITAL LP | 0 | 205,622 | +205,622 | 0.00 | 2.67 | +2.67 | buy |
| HSBC HOLDINGS PLC | 0 | 187,765 | +187,765 | 0.00 | 0.01 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 245,832 | 186,312 | -59,520 | 0.22 | 0.34 | +0.11 | sell |
| ADAR1 Capital Management, LLC | 258,139 | 185,699 | -72,440 | 0.80 | 0.76 | -0.05 | sell |
| CITADEL ADVISORS LLC | 681,186 | 172,815 | -508,371 | 0.02 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 155,156 | 167,030 | +11,874 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 361,158 | 166,349 | -194,809 | 2.17 | 1.33 | -0.84 | sell |
| PFM Health Sciences, LP | 163,967 | 165,925 | +1,958 | 0.69 | 1.18 | +0.49 | buy |
| Russell Investments Group, Ltd. | 143,346 | 163,172 | +19,826 | 0.01 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 150,188 | 156,454 | +6,266 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 281,059 | 156,327 | -124,732 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 3,500 | 148,750 | +145,250 | 0.00 | 0.02 | +0.02 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,834 | 144,103 | +106,269 | 0.00 | 0.02 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 201,918 | 136,841 | -65,077 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,478 | 136,544 | +8,066 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 134,692 | 128,414 | -6,278 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 112,349 | 114,342 | +1,993 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 96,103 | 108,039 | +11,936 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 300,000 | 100,000 | -200,000 | 4.54 | 2.77 | -1.77 | sell |
| Opaleye Management Inc. | 410,000 | 94,800 | -315,200 | 2.25 | 0.85 | -1.40 | sell |
| Invesco Ltd. | 38,140 | 91,994 | +53,854 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 84,400 | 84,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 70,601 | 71,082 | +481 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 66,038 | 68,737 | +2,699 | 0.02 | 0.02 | +0.01 | buy |
| Rafferty Asset Management, LLC | 106,052 | 67,979 | -38,073 | 0.02 | 0.02 | +0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 2,850 | 67,404 | +64,554 | 0.00 | 0.05 | +0.05 | buy |
| Blackstone Inc. | 0 | 64,128 | +64,128 | 0.00 | 0.02 | +0.02 | buy |
| Tidal Investments LLC | 0 | 63,163 | +63,163 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 36,057 | 63,163 | +27,106 | 0.12 | 0.29 | +0.17 | buy |
| BNP Paribas Asset Management Holding S.A. | 58,118 | 57,732 | -386 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 43,721 | 57,291 | +13,570 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,658 | 51,499 | +9,841 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 49,628 | +49,628 | 0.00 | 0.10 | +0.10 | buy |
| Nantahala Capital Management, LLC | 109,449 | 49,449 | -60,000 | 0.27 | 0.21 | -0.06 | sell |
| D. E. Shaw & Co., Inc. | 23,028 | 46,610 | +23,582 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 46,102 | +46,102 | 0.00 | 0.36 | +0.36 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,127 | 45,615 | +2,488 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 49,928 | 40,570 | -9,358 | 0.06 | 0.09 | +0.02 | sell |
| Legal & General Group Plc | 45,147 | 38,008 | -7,139 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 32,348 | 32,604 | +256 | 0.01 | 0.01 | +0.00 | buy |
| Lynx1 Capital Management LP | 31,591 | 31,591 | 0 | 0.27 | 0.34 | +0.07 | hold |
| PROFUND ADVISORS LLC | 39,319 | 30,688 | -8,631 | 0.05 | 0.08 | +0.03 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27,753 | 27,753 | 0 | 0.01 | 0.01 | +0.01 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,326 | 26,840 | -486 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 25,803 | +25,803 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 37,171 | 25,017 | -12,154 | 0.09 | 0.11 | +0.02 | sell |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.28 | 0.43 | +0.16 | hold |
| SG Americas Securities, LLC | 20,949 | 24,632 | +3,683 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 62,552 | 24,600 | -37,952 | 0.00 | 0.00 | -0.00 | sell |
| Knights of Columbus Asset Advisors LLC | 17,800 | 23,200 | +5,400 | 0.04 | 0.09 | +0.05 | buy |
| WESBANCO BANK INC | 27,000 | 22,300 | -4,700 | 0.03 | 0.04 | +0.01 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 55,151 | 21,776 | -33,375 | 0.00 | 0.00 | -0.00 | sell |