| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 1,130,235 | 3,309,507 | +2,179,272 | 1.60 | 3.28 | +1.68 | buy |
| RTW INVESTMENTS, LP | 413,670 | 1,344,074 | +930,404 | 0.27 | 0.66 | +0.39 | buy |
| BVF INC/IL | 1,884,191 | 2,417,885 | +533,694 | 2.27 | 2.14 | -0.13 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 47,540 | 433,540 | +386,000 | 0.04 | 0.23 | +0.19 | buy |
| CenterBook Partners LP | 11,836 | 335,310 | +323,474 | 0.04 | 0.66 | +0.62 | buy |
| Polar Capital Holdings Plc | 729,166 | 967,055 | +237,889 | 0.17 | 0.18 | +0.01 | buy |
| Soleus Capital Management, L.P. | 217,871 | 424,585 | +206,714 | 0.84 | 1.18 | +0.34 | buy |
| Cormorant Asset Management, LP | 800,000 | 975,000 | +175,000 | 1.54 | 1.78 | +0.24 | buy |
| TimesSquare Capital Management, LLC | 224,073 | 343,059 | +118,986 | 0.14 | 0.17 | +0.03 | buy |
| TCG Crossover Management, LLC | 3,570,206 | 3,670,206 | +100,000 | 12.39 | 12.08 | -0.31 | buy |
| JANUS HENDERSON GROUP PLC | 1,521,432 | 1,427,017 | +94,415 | 0.04 | 0.02 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 2,050 | 12,850 | +10,800 | 0.02 | 0.08 | +0.06 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 259,888 | 266,787 | +6,899 | 0.00 | 0.00 | -0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 7,449 | 9,588 | +2,139 | 0.03 | 0.03 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 196,107 | 196,259 | +152 | 0.10 | 0.07 | -0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 107,957 | 106,951 | -1,006 | 0.05 | 0.03 | -0.01 | sell |
| Scientech Research LLC | 12,194 | 8,803 | -3,391 | 0.28 | 0.06 | -0.23 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 455,000 | 330,000 | -125,000 | 0.04 | 0.02 | -0.02 | sell |
| Ally Bridge Group (NY) LLC | 320,378 | 174,876 | -145,502 | 7.82 | 3.29 | -4.53 | sell |
| Avidity Partners Management LP | 1,454,765 | 1,296,225 | -158,540 | 2.27 | 1.74 | -0.53 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 992,118 | 665,145 | -326,973 | 0.01 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,304,105 | 733,695 | -570,410 | 1.00 | 0.56 | -0.44 | sell |
| T. Rowe Price Investment Management, Inc. | 708,711 | 66,596 | -642,115 | 0.02 | 0.00 | -0.02 | sell |