| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Decheng Capital LLC | 5,458,810 | 5,458,810 | 0 | 32.14 | 52.81 | +20.67 | hold |
| TCG Crossover Management, LLC | 3,570,206 | 3,670,206 | +100,000 | 12.39 | 12.08 | -0.31 | buy |
| BRAIDWELL LP | 1,130,235 | 3,309,507 | +2,179,272 | 1.60 | 3.28 | +1.68 | buy |
| BVF INC/IL | 1,884,191 | 2,417,885 | +533,694 | 2.27 | 2.14 | -0.13 | buy |
| VANGUARD GROUP INC | 2,225,018 | 2,244,121 | +19,103 | 0.00 | 0.00 | -0.00 | buy |
| Yu Fan | 0 | 1,578,344 | +1,578,344 | 0.00 | 65.11 | +65.11 | buy |
| JANUS HENDERSON GROUP PLC | 1,521,432 | 1,427,017 | -94,415 | 0.04 | 0.02 | -0.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 1,397,433 | 1,397,433 | 0 | 0.78 | 0.58 | -0.20 | hold |
| RTW INVESTMENTS, LP | 413,670 | 1,344,074 | +930,404 | 0.27 | 0.66 | +0.39 | buy |
| Avidity Partners Management LP | 1,454,765 | 1,296,225 | -158,540 | 2.27 | 1.74 | -0.53 | sell |
| FRANKLIN RESOURCES INC | 848,092 | 1,130,087 | +281,995 | 0.01 | 0.01 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 929,752 | 1,009,783 | +80,031 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 350,831 | 982,931 | +632,100 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 800,000 | 975,000 | +175,000 | 1.55 | 1.79 | +0.24 | buy |
| Polar Capital Holdings Plc | 729,166 | 967,055 | +237,889 | 0.17 | 0.18 | +0.01 | buy |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 915,501 | 915,501 | 0 | 96.81 | 96.44 | -0.37 | hold |
| Frazier Life Sciences Management, L.P. | 770,000 | 770,000 | 0 | 1.43 | 1.14 | -0.29 | hold |
| PERCEPTIVE ADVISORS LLC | 1,304,105 | 733,695 | -570,410 | 1.01 | 0.56 | -0.45 | sell |
| Avoro Capital Advisors LLC | 700,000 | 700,000 | 0 | 0.36 | 0.29 | -0.06 | hold |
| Foresite Capital Management V, LLC | 692,550 | 692,550 | 0 | 28.54 | 13.96 | -14.58 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 992,118 | 665,145 | -326,973 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 504,216 | 549,778 | +45,562 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 525,199 | 525,199 | 0 | 0.21 | 0.16 | -0.05 | hold |
| CITADEL ADVISORS LLC | 276,461 | 491,694 | +215,233 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 471,090 | +471,090 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 47,540 | 433,540 | +386,000 | 0.04 | 0.23 | +0.19 | buy |
| Soleus Capital Management, L.P. | 217,871 | 424,585 | +206,714 | 0.84 | 1.18 | +0.34 | buy |
| TimesSquare Capital Management, LLC | 224,073 | 343,059 | +118,986 | 0.14 | 0.17 | +0.03 | buy |
| CenterBook Partners LP | 11,836 | 335,310 | +323,474 | 0.04 | 0.66 | +0.62 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 455,000 | 330,000 | -125,000 | 0.04 | 0.02 | -0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 259,888 | 266,787 | +6,899 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 106,319 | 211,006 | +104,687 | 0.05 | 0.07 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 198,807 | 201,367 | +2,560 | 0.00 | 0.00 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 196,107 | 196,259 | +152 | 0.10 | 0.07 | -0.02 | buy |
| NORTHERN TRUST CORP | 183,004 | 183,980 | +976 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,352 | 177,402 | +8,050 | 0.00 | 0.00 | -0.00 | buy |
| Ally Bridge Group (NY) LLC | 320,378 | 174,876 | -145,502 | 7.82 | 3.29 | -4.53 | sell |
| Point72 Asset Management, L.P. | 186,237 | 110,410 | -75,827 | 0.02 | 0.01 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 107,957 | 106,951 | -1,006 | 0.05 | 0.03 | -0.01 | sell |
| MORGAN STANLEY | 73,724 | 94,709 | +20,985 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 93,084 | +93,084 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 64,543 | 89,344 | +24,801 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 23,323 | 78,080 | +54,757 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 75,982 | +75,982 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 708,711 | 66,596 | -642,115 | 0.02 | 0.00 | -0.02 | sell |
| Ensign Peak Advisors, Inc | 0 | 60,565 | +60,565 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,774 | 60,301 | -3,473 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 76,353 | 57,551 | -18,802 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 14,147 | 56,195 | +42,048 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 0 | 53,911 | +53,911 | 0.00 | 0.18 | +0.18 | buy |
| ALPS ADVISORS INC | 0 | 51,981 | +51,981 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 0 | 50,965 | +50,965 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 14,200 | 43,200 | +29,000 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 39,400 | +39,400 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 37,962 | +37,962 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 30,289 | 34,229 | +3,940 | 0.00 | 0.00 | -0.00 | buy |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.40 | 0.30 | -0.10 | hold |
| Ghisallo Capital Management LLC | 25,000 | 25,000 | 0 | 0.13 | 0.07 | -0.06 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 23,625 | +23,625 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 16,353 | 20,997 | +4,644 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,341 | 19,808 | +17,467 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 9,538 | 19,529 | +9,991 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,162 | 19,135 | +16,973 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 15,775 | +15,775 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 13,616 | 13,616 | 0 | 0.02 | 0.01 | -0.01 | hold |
| MetLife Investment Management, LLC | 12,106 | 13,352 | +1,246 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 13,233 | +13,233 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 558,197 | 13,072 | -545,125 | 0.02 | 0.00 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 2,050 | 12,850 | +10,800 | 0.02 | 0.08 | +0.06 | buy |
| Invesco Ltd. | 12,183 | 12,406 | +223 | 0.00 | 0.00 | -0.00 | buy |
| M&T BANK CORP | 9,580 | 10,762 | +1,182 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 4,284 | 10,609 | +6,325 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,000 | 10,596 | +3,596 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,623 | 10,546 | +923 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 10,476 | +10,476 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 10,693 | 9,827 | -866 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 7,449 | 9,588 | +2,139 | 0.03 | 0.03 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 9,513 | +9,513 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 12,194 | 8,803 | -3,391 | 0.28 | 0.06 | -0.23 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 6,956 | 7,821 | +865 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 7,536 | +7,536 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 7,039 | +7,039 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 5,127 | +5,127 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 11,198 | 2,729 | -8,469 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 0 | 2,601 | +2,601 | 0.00 | 0.04 | +0.04 | buy |
| Ameritas Investment Partners, Inc. | 2,320 | 2,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 1,645 | +1,645 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 4,933 | 1,209 | -3,724 | 0.06 | 0.01 | -0.05 | sell |
| Strengthening Families & Communities, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.01 | +0.01 | buy |
| AMALGAMATED BANK | 781 | 781 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 0 | 765 | +765 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 290 | +290 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 276 | +276 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 264 | +264 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 157 | 174 | +17 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 143 | +143 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 55 | 55 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 49 | 49 | 0 | 0.00 | 0.00 | -0.00 | hold |