| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BANK OF AMERICA CORP /DE/ | 340,599 | 1,736,769 | +1,396,170 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,545,098 | 3,856,261 | +1,311,163 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,014,596 | 2,013,690 | +999,094 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 945,081 | 1,868,148 | +923,067 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 763,580 | +763,580 | 0.00 | 0.11 | +0.11 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 179,363 | 856,597 | +677,234 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 747,829 | 1,354,383 | +606,554 | 0.02 | 0.04 | +0.02 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 555,117 | +555,117 | 0.00 | 1.55 | +1.55 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 541,034 | +541,034 | 0.00 | 2.88 | +2.88 | buy |
| UBS Group AG | 1,704,718 | 2,229,245 | +524,527 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 980,942 | 1,499,942 | +519,000 | 4.95 | 7.82 | +2.86 | buy |
| GOLDMAN SACHS GROUP INC | 767,266 | 1,187,101 | +419,835 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 596,056 | 959,968 | +363,912 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,882,577 | 2,164,214 | +281,637 | 0.02 | 0.02 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 134,400 | 396,479 | +262,079 | 0.01 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 92,539 | 346,500 | +253,961 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 32,158 | 259,211 | +227,053 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 301,134 | 523,216 | +222,082 | 1.42 | 2.21 | +0.79 | buy |
| STATE STREET CORP | 1,967,489 | 2,165,753 | +198,264 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 192,974 | +192,974 | 0.00 | 2.43 | +2.43 | buy |
| FRANKLIN RESOURCES INC | 1,318,934 | 1,486,839 | +167,905 | 0.01 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 108,302 | 264,039 | +155,737 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 155,000 | +155,000 | 0.00 | 1.33 | +1.33 | buy |
| Alyeska Investment Group, L.P. | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| Foresite Capital Management V, LLC | 859,050 | 1,004,050 | +145,000 | 24.01 | 32.34 | +8.33 | buy |
| TD ASSET MANAGEMENT INC | 68,306 | 203,872 | +135,566 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 163,988 | 266,000 | +102,012 | 0.89 | 1.40 | +0.51 | buy |
| BlackRock, Inc. | 4,355,060 | 4,456,423 | +101,363 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 19,381 | 113,032 | +93,651 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 19,245 | 110,456 | +91,211 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 87,500 | +87,500 | 0.00 | 0.11 | +0.11 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 86,600 | +86,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 77,435 | 153,872 | +76,437 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,779 | 79,660 | +75,881 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 5,836,320 | 5,906,511 | +70,191 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 67,667 | +67,667 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 18,955 | 84,856 | +65,901 | 0.04 | 0.12 | +0.09 | buy |
| ArrowMark Colorado Holdings LLC | 235,194 | 293,006 | +57,812 | 0.09 | 0.14 | +0.04 | buy |
| CenterBook Partners LP | 203,128 | 260,099 | +56,971 | 0.32 | 0.38 | +0.06 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 56,255 | +56,255 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,279,234 | 1,335,437 | +56,203 | 0.00 | 0.00 | -0.00 | buy |
| Polar Capital Holdings Plc | 1,042,860 | 1,098,662 | +55,802 | 0.16 | 0.15 | -0.01 | buy |
| NOMURA HOLDINGS INC | 0 | 46,239 | +46,239 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 46,100 | +46,100 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 0 | 38,479 | +38,479 | 0.00 | 0.06 | +0.06 | buy |
| Tejara Capital Ltd | 0 | 36,291 | +36,291 | 0.00 | 0.44 | +0.44 | buy |
| WESBANCO BANK INC | 0 | 27,000 | +27,000 | 0.00 | 0.02 | +0.02 | buy |
| TWINBEECH CAPITAL LP | 0 | 26,979 | +26,979 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 26,000 | +26,000 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 0 | 25,573 | +25,573 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 28,612 | 46,081 | +17,469 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 28,612 | 46,081 | +17,469 | 0.21 | 0.32 | +0.11 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 16,933 | +16,933 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 15,758 | +15,758 | 0.00 | 0.13 | +0.13 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,985 | 93,793 | +11,808 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 439,278 | 450,296 | +11,018 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 10,795 | +10,795 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 9,309 | +9,309 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 9,239 | +9,239 | 0.00 | 0.02 | +0.02 | buy |
| Saturn V Capital Management LP | 577,696 | 586,647 | +8,951 | 7.14 | 6.18 | -0.96 | buy |
| E Fund Management Co., Ltd. | 0 | 8,932 | +8,932 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,522 | 44,328 | +8,806 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 71,426 | 80,228 | +8,802 | 0.01 | 0.01 | -0.00 | buy |
| WINTON GROUP Ltd | 0 | 8,669 | +8,669 | 0.00 | 0.01 | +0.01 | buy |
| Man Group plc | 0 | 8,619 | +8,619 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 8,556 | +8,556 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 0 | 8,043 | +8,043 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 8,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 74,689 | 82,424 | +7,735 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 22,556 | 29,059 | +6,503 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 39,507 | 44,354 | +4,847 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 67,717 | 72,143 | +4,426 | 0.12 | 0.11 | -0.01 | buy |
| Tower Research Capital LLC (TRC) | 2,694 | 6,982 | +4,288 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 13,300 | 17,500 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 2,110 | 6,193 | +4,083 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 3,985 | +3,985 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,996 | 17,796 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 5,479 | 9,271 | +3,792 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 35,052 | 37,979 | +2,927 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,144 | 16,985 | +1,841 | 0.02 | 0.02 | -0.00 | buy |
| MetLife Investment Management, LLC | 31,815 | 33,589 | +1,774 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 8,500 | 10,200 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 27,754 | 29,231 | +1,477 | 0.00 | 0.00 | +0.00 | buy |
| Winthrop Capital Management, LLC | 0 | 1,467 | +1,467 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,647 | 12,879 | +1,232 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,030 | 15,109 | +1,079 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 50 | 749 | +699 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,147 | 34,655 | +508 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 4 | 469 | +465 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 94 | 531 | +437 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 2,846 | 3,279 | +433 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 213 | 628 | +415 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,547 | 2,945 | +398 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 381 | +381 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 55 | 403 | +348 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 343 | +343 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 15 | 350 | +335 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,944 | 12,204 | +260 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,125 | 11,300 | +175 | 0.00 | 0.00 | +0.00 | buy |