| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,014,596 | 2,013,690 | +999,094 | 0.00 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 980,942 | 1,499,942 | +519,000 | 4.95 | 7.82 | +2.86 | buy |
| ADAR1 Capital Management, LLC | 301,134 | 523,216 | +222,082 | 1.42 | 2.21 | +0.79 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 108,302 | 264,039 | +155,737 | 0.00 | 0.01 | +0.00 | buy |
| Foresite Capital Management V, LLC | 859,050 | 1,004,050 | +145,000 | 24.01 | 32.34 | +8.33 | buy |
| Opaleye Management Inc. | 163,988 | 266,000 | +102,012 | 0.89 | 1.40 | +0.51 | buy |
| Cinctive Capital Management LP | 18,955 | 84,856 | +65,901 | 0.04 | 0.12 | +0.09 | buy |
| ArrowMark Colorado Holdings LLC | 235,194 | 293,006 | +57,812 | 0.09 | 0.14 | +0.04 | buy |
| CenterBook Partners LP | 203,128 | 260,099 | +56,971 | 0.32 | 0.38 | +0.06 | buy |
| Polar Capital Holdings Plc | 1,042,860 | 1,098,662 | +55,802 | 0.16 | 0.15 | -0.01 | buy |
| NEOS Investment Management LLC | 28,612 | 46,081 | +17,469 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 28,612 | 46,081 | +17,469 | 0.21 | 0.32 | +0.11 | buy |
| ALPS ADVISORS INC | 56,399 | 41,069 | +15,330 | 0.01 | 0.01 | 0.00 | sell |
| Saturn V Capital Management LP | 577,696 | 586,647 | +8,951 | 7.14 | 6.18 | -0.96 | buy |
| Rafferty Asset Management, LLC | 71,426 | 80,228 | +8,802 | 0.01 | 0.01 | -0.00 | buy |
| PDT Partners, LLC | 67,717 | 72,143 | +4,426 | 0.12 | 0.11 | -0.01 | buy |
| PROFUND ADVISORS LLC | 15,144 | 16,985 | +1,841 | 0.02 | 0.02 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,270 | 15,310 | +40 | 0.03 | 0.04 | +0.00 | buy |
| iA Global Asset Management Inc. | 45,550 | 44,400 | -1,150 | 0.02 | 0.02 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 5,686 | 3,548 | -2,138 | 0.04 | 0.03 | -0.01 | sell |
| TimesSquare Capital Management, LLC | 517,258 | 512,201 | -5,057 | 100.00 | 0.19 | -99.81 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 258,090 | 249,664 | -8,426 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 22,305 | 10,328 | -11,977 | 0.21 | 0.10 | -0.11 | sell |
| SummitTX Capital, L.P. | 63,191 | 27,256 | -35,935 | 0.07 | 0.03 | -0.04 | sell |
| Woodline Partners LP | 764,357 | 629,357 | -135,000 | 0.12 | 0.09 | -0.04 | sell |
| Soleus Capital Management, L.P. | 303,585 | 155,000 | -148,585 | 0.58 | 0.28 | -0.30 | sell |
| Cormorant Asset Management, LP | 775,000 | 625,000 | -150,000 | 1.43 | 1.21 | -0.22 | sell |
| Kynam Capital Management, LP | 2,611,662 | 2,457,667 | -153,995 | 5.47 | 6.88 | +1.41 | sell |
| ORBIMED ADVISORS LLC | 2,471,994 | 1,877,850 | -594,144 | 1.45 | 1.23 | -0.23 | sell |