| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 6,984,808 | 8,514,590 | +1,529,782 | 4.70 | 5.16 | +0.46 | buy |
| T. Rowe Price Investment Management, Inc. | 6,720,389 | 6,616,899 | -103,490 | 0.31 | 0.31 | -0.01 | sell |
| Decheng Capital LLC | 6,371,669 | 6,371,669 | 0 | 65.21 | 61.87 | -3.34 | hold |
| BlackRock, Inc. | 5,064,180 | 6,256,288 | +1,192,108 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,371,232 | 5,324,751 | -46,481 | 0.07 | 0.07 | -0.00 | sell |
| FMR LLC | 3,764,844 | 4,161,493 | +396,649 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,652,980 | 3,805,010 | +152,030 | 0.03 | 0.03 | -0.00 | buy |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 7.11 | 6.27 | -0.84 | hold |
| STATE STREET CORP | 2,647,054 | 3,437,590 | +790,536 | 0.01 | 0.01 | +0.00 | buy |
| Foresite Capital Management VI LLC | 2,221,474 | 2,369,574 | +148,100 | 32.67 | 26.20 | -6.46 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,596,864 | 2,153,277 | +556,413 | 0.01 | 0.01 | +0.00 | buy |
| EcoR1 Capital, LLC | 1,102,000 | 1,494,300 | +392,300 | 3.19 | 5.26 | +2.08 | buy |
| Avidity Partners Management LP | 1,288,948 | 1,398,948 | +110,000 | 17.67 | 15.92 | -1.75 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,290,087 | 1,374,149 | +84,062 | 0.02 | 0.03 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,507,005 | 1,312,880 | -194,125 | 0.02 | 0.02 | -0.00 | sell |
| MORGAN STANLEY | 520,213 | 1,177,109 | +656,896 | 0.00 | 0.00 | +0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,130,501 | 1,131,500 | +999 | 21.77 | 21.94 | +0.17 | buy |
| Foresite Capital Management V, LLC | 1,004,050 | 1,079,050 | +75,000 | 25.08 | 21.17 | -3.91 | buy |
| Logos Global Management LP | 575,000 | 1,000,000 | +425,000 | 2.00 | 3.06 | +1.05 | buy |
| BANK OF AMERICA CORP /DE/ | 1,449,364 | 984,918 | -464,446 | 0.01 | 0.00 | -0.00 | sell |
| UBS Group AG | 1,311,978 | 977,695 | -334,283 | 0.02 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 948,267 | 972,800 | +24,533 | 1.40 | 1.31 | -0.09 | buy |
| SG Americas Securities, LLC | 24,632 | 867,465 | +842,833 | 0.00 | 0.04 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 1,159,239 | 857,713 | -301,526 | 0.01 | 0.01 | -0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 769,947 | +769,947 | 0.00 | 0.50 | +0.50 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,064,966 | 761,807 | -303,159 | 0.01 | 0.01 | -0.01 | sell |
| Clearbridge Investments, LLC | 730,283 | 735,736 | +5,453 | 0.04 | 0.04 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 4,907 | 726,154 | +721,247 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 519,669 | 677,912 | +158,243 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 627,185 | +627,185 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542,378 | 627,185 | +84,807 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 493,596 | +493,596 | 0.00 | 0.74 | +0.74 | buy |
| Woodline Partners LP | 492,891 | 492,891 | 0 | 0.13 | 0.11 | -0.02 | hold |
| Caption Management, LLC | 378,480 | 484,461 | +105,981 | 1.22 | 1.21 | -0.01 | buy |
| Candriam S.C.A. | 542,036 | 469,170 | -72,866 | 0.19 | 0.15 | -0.04 | sell |
| Fisher Asset Management, LLC | 465,033 | 456,978 | -8,055 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 438,673 | 433,882 | -4,791 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 559,586 | 417,726 | -141,860 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 399,858 | 390,458 | -9,400 | 0.04 | 0.04 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 456,012 | 380,546 | -75,466 | 0.06 | 0.04 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 369,985 | 369,839 | -146 | 0.41 | 0.35 | -0.06 | sell |
| LORD, ABBETT & CO. LLC | 340,197 | 364,539 | +24,342 | 0.08 | 0.07 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 476,136 | 317,235 | -158,901 | 0.02 | 0.01 | -0.01 | sell |
| FEDERATED HERMES, INC. | 148,750 | 311,236 | +162,486 | 0.02 | 0.03 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 108,039 | 304,167 | +196,128 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 0 | 287,632 | +287,632 | 0.00 | 0.03 | +0.03 | buy |
| Pictet Asset Management Holding SA | 398,005 | 255,059 | -142,946 | 0.03 | 0.02 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 333,192 | 233,517 | -99,675 | 0.02 | 0.01 | -0.01 | sell |
| Bank of New York Mellon Corp | 167,030 | 233,419 | +66,389 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 253,708 | 210,884 | -42,824 | 0.29 | 0.22 | -0.07 | sell |
| AMERIPRISE FINANCIAL INC | 311,523 | 209,477 | -102,046 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 156,454 | 197,514 | +41,060 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 128,414 | 188,420 | +60,006 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 288,756 | 183,756 | -105,000 | 0.02 | 0.01 | -0.00 | sell |
| HSBC HOLDINGS PLC | 187,765 | 175,765 | -12,000 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 163,172 | 166,633 | +3,461 | 0.01 | 0.01 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 205,622 | 159,349 | -46,273 | 2.67 | 1.96 | -0.72 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 136,841 | 155,390 | +18,549 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 186,312 | 155,354 | -30,958 | 0.34 | 0.46 | +0.12 | sell |
| CITIGROUP INC | 14,196 | 135,225 | +121,029 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 165,925 | 128,286 | -37,639 | 1.18 | 0.79 | -0.39 | sell |
| ADAR1 Capital Management, LLC | 185,699 | 118,664 | -67,035 | 0.76 | 0.40 | -0.36 | sell |
| BARCLAYS PLC | 11,499 | 118,613 | +107,114 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 114,342 | 102,397 | -11,945 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 84,400 | 101,700 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 71,082 | 90,849 | +19,767 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 46,610 | 89,417 | +42,807 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 68,737 | 89,218 | +20,481 | 0.02 | 0.03 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 136,544 | 81,157 | -55,387 | 0.01 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 24,600 | 76,220 | +51,620 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 63,163 | 68,702 | +5,539 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 63,163 | 68,702 | +5,539 | 0.29 | 0.16 | -0.13 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 67,404 | 63,867 | -3,537 | 0.05 | 0.04 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 0 | 61,729 | +61,729 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,499 | 57,909 | +6,410 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 57,732 | 55,422 | -2,310 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 9,700 | 53,455 | +43,755 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 91,994 | 52,406 | -39,588 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 51,849 | +51,849 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 67,979 | 50,263 | -17,716 | 0.02 | 0.01 | -0.01 | sell |
| ALGERT GLOBAL LLC | 19,380 | 46,690 | +27,310 | 0.02 | 0.04 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,615 | 44,740 | -875 | 0.00 | 0.00 | -0.00 | sell |
| Polar Capital Holdings Plc | 704,461 | 43,483 | -660,978 | 0.21 | 0.01 | -0.20 | sell |
| MetLife Investment Management, LLC | 32,604 | 43,027 | +10,423 | 0.01 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 144,103 | 41,827 | -102,276 | 0.02 | 0.00 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 14,171 | 41,311 | +27,140 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 38,008 | 40,062 | +2,054 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 57,291 | 33,586 | -23,705 | 0.00 | 0.00 | -0.00 | sell |
| Lynx1 Capital Management LP | 31,591 | 31,391 | -200 | 0.34 | 0.26 | -0.08 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156,327 | 28,837 | -127,490 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,840 | 27,216 | +376 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,796 | 25,996 | +8,200 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 30,688 | 25,972 | -4,716 | 0.08 | 0.05 | -0.03 | sell |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.43 | 0.43 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,609 | 23,354 | +11,745 | 0.00 | 0.00 | +0.00 | buy |
| WESBANCO BANK INC | 22,300 | 22,300 | 0 | 0.04 | 0.04 | -0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27,753 | 22,107 | -5,646 | 0.01 | 0.01 | -0.00 | sell |
| Handelsbanken Fonder AB | 20,700 | 21,900 | +1,200 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 16,209 | 21,767 | +5,558 | 0.01 | 0.01 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 20,964 | +20,964 | 0.00 | 0.01 | +0.01 | buy |